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A1CMH6

- BGLE_ASPCL

UniProt

A1CMH6 - BGLE_ASPCL

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Protein

Probable beta-glucosidase E

Gene
bglE, ACLA_096980
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei458 – 4581 By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:ACLA_096980
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 174174Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei175 – 19521Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini196 – 1050855Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10501050Probable beta-glucosidase EPRO_0000394870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi236 – 2361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi501 – 5011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi540 – 5401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi605 – 6051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi884 – 8841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi920 – 9201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi929 – 9291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi993 – 9931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00009117.

Structurei

3D structure databases

ProteinModelPortaliA1CMH6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiHYDRINS.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

A1CMH6-1 [UniParc]FASTAAdd to Basket

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MPPPDSNPGS FRDHLKHDNK NNNSSTTSKG KQRYTPLHDS IPEEIASPRS     50
ASASSSFDLD PDLENQSRND YKLRPLARSS STNGGHNYST AYIPVIRDEG 100
DDVETYLDSI TEAEQELLSL SKQYDFADDS DDFDSDDDAA LRRKVQKQEQ 150
RRRRERLKAK VWTPVKYARI WRRTLVVVIV ALALLVWGFL RFTAAQRQGP 200
KVWPMLPSDS WFPSPKGGTL KHWEESYRKA QSLVRNMTLI EKVNITTGTG 250
WQMGMCVGNT GPAELVKFPS LCLQDGPQGL RYADHVTAFP AGITTGSTWN 300
RTLMRERGIA MGREARLKGV NVLLGPSIGP IGMMPAGGRN WEGFGSDPVL 350
QGVAAAETIR GIQSNGVMAT AKHFLMNEQE HFRQPFEWGI STALSSNVGD 400
RALHEVFAWP FAESIRADVA SVMCSYQMVN NSHACENSKL LNGILKDELG 450
FQGFVQSDWL AQRSGINSAL GGLDMSMPGD GLHWTDGKSL WGRELTRAVL 500
NTSIPMERLN DMVTRIVAAW YQFEQDEWER PPPEGNGGPN FSSWTGGDVG 550
WLHAGSNDGL YAVVNQYIDA QGTGPEAHSI IARKVAAEGT VLLKNVDHTL 600
PLSRNASGPS GVMRVGIYGD DAGPAQGPNA CPDRGCNQGT LATGWGSGTV 650
DFPYLVSPLE ALETAWKTEV EMTAFLRNAV MPADVADKDL CLVFANADSG 700
EGFISAGGIH GDRNDLFLQK GGDTLIRTVA SHCGEGQGKT VVVIHAVGPV 750
VMESWIDLPG VHAVLLANLP GQESGNALMD VLFGDVDASG RLPYTIGKSL 800
EEYGTEAQVL YEPNAPVPQV DLLDALFIDY RHFDQYNITP RFEFGFGLSY 850
TTFKLKDLHV RSLQSKSRSP AARPAAAVSP PEYNTTLPDP ALALFPPGFQ 900
PVYKYIYPYL PSLDGTAPAN YSYYPKDYNQ TQGPSPAGGG AGGNPALFQE 950
MASVSVQVQN TGDRKGQEVV QVYVSFPSDE KVKIDFPERV LRNFTKVELE 1000
PGERREVQMT LSRKDLSYWS VREQNWVMPD GDFQIWVGRS SRDLPLQAKY 1050
Length:1,050
Mass (Da):115,389
Last modified:January 23, 2007 - v1
Checksum:i0EE88C1BD581414E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027058 Genomic DNA. Translation: EAW08763.1.
RefSeqiXP_001270189.1. XM_001270188.1.

Genome annotation databases

EnsemblFungiiCADACLAT00009341; CADACLAP00009117; CADACLAG00009341.
GeneIDi4702262.
KEGGiact:ACLA_096980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027058 Genomic DNA. Translation: EAW08763.1 .
RefSeqi XP_001270189.1. XM_001270188.1.

3D structure databases

ProteinModelPortali A1CMH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00009117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00009341 ; CADACLAP00009117 ; CADACLAG00009341 .
GeneIDi 4702262.
KEGGi act:ACLA_096980.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
KOi K05349.
OMAi HYDRINS.
OrthoDBi EOG7HMS8F.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBGLE_ASPCL
AccessioniPrimary (citable) accession number: A1CMH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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