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Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei458By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:ACLA_096980
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_096980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 174CytoplasmicSequence analysisAdd BLAST174
Transmembranei175 – 195Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini196 – 1050ExtracellularSequence analysisAdd BLAST855

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948701 – 1050Probable beta-glucosidase EAdd BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi884N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi929N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi993N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1CMH6

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00009117

Structurei

3D structure databases

ProteinModelPortaliA1CMH6
SMRiA1CMH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000031215
KOiK05349
OMAiCSYQMVN
OrthoDBiEOG092C0ZJY

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.20.20.300, 1 hit
3.40.50.1700, 1 hit
InterProiView protein in InterPro
IPR026891 Fn3-like
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF14310 Fn3-like, 1 hit
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM01217 Fn3_like, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 2 hits

Sequencei

Sequence statusi: Complete.

A1CMH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPDSNPGS FRDHLKHDNK NNNSSTTSKG KQRYTPLHDS IPEEIASPRS
60 70 80 90 100
ASASSSFDLD PDLENQSRND YKLRPLARSS STNGGHNYST AYIPVIRDEG
110 120 130 140 150
DDVETYLDSI TEAEQELLSL SKQYDFADDS DDFDSDDDAA LRRKVQKQEQ
160 170 180 190 200
RRRRERLKAK VWTPVKYARI WRRTLVVVIV ALALLVWGFL RFTAAQRQGP
210 220 230 240 250
KVWPMLPSDS WFPSPKGGTL KHWEESYRKA QSLVRNMTLI EKVNITTGTG
260 270 280 290 300
WQMGMCVGNT GPAELVKFPS LCLQDGPQGL RYADHVTAFP AGITTGSTWN
310 320 330 340 350
RTLMRERGIA MGREARLKGV NVLLGPSIGP IGMMPAGGRN WEGFGSDPVL
360 370 380 390 400
QGVAAAETIR GIQSNGVMAT AKHFLMNEQE HFRQPFEWGI STALSSNVGD
410 420 430 440 450
RALHEVFAWP FAESIRADVA SVMCSYQMVN NSHACENSKL LNGILKDELG
460 470 480 490 500
FQGFVQSDWL AQRSGINSAL GGLDMSMPGD GLHWTDGKSL WGRELTRAVL
510 520 530 540 550
NTSIPMERLN DMVTRIVAAW YQFEQDEWER PPPEGNGGPN FSSWTGGDVG
560 570 580 590 600
WLHAGSNDGL YAVVNQYIDA QGTGPEAHSI IARKVAAEGT VLLKNVDHTL
610 620 630 640 650
PLSRNASGPS GVMRVGIYGD DAGPAQGPNA CPDRGCNQGT LATGWGSGTV
660 670 680 690 700
DFPYLVSPLE ALETAWKTEV EMTAFLRNAV MPADVADKDL CLVFANADSG
710 720 730 740 750
EGFISAGGIH GDRNDLFLQK GGDTLIRTVA SHCGEGQGKT VVVIHAVGPV
760 770 780 790 800
VMESWIDLPG VHAVLLANLP GQESGNALMD VLFGDVDASG RLPYTIGKSL
810 820 830 840 850
EEYGTEAQVL YEPNAPVPQV DLLDALFIDY RHFDQYNITP RFEFGFGLSY
860 870 880 890 900
TTFKLKDLHV RSLQSKSRSP AARPAAAVSP PEYNTTLPDP ALALFPPGFQ
910 920 930 940 950
PVYKYIYPYL PSLDGTAPAN YSYYPKDYNQ TQGPSPAGGG AGGNPALFQE
960 970 980 990 1000
MASVSVQVQN TGDRKGQEVV QVYVSFPSDE KVKIDFPERV LRNFTKVELE
1010 1020 1030 1040 1050
PGERREVQMT LSRKDLSYWS VREQNWVMPD GDFQIWVGRS SRDLPLQAKY
Length:1,050
Mass (Da):115,389
Last modified:January 23, 2007 - v1
Checksum:i0EE88C1BD581414E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027058 Genomic DNA Translation: EAW08763.1
RefSeqiXP_001270189.1, XM_001270188.1

Genome annotation databases

EnsemblFungiiCADACLAT00009341; CADACLAP00009117; CADACLAG00009341
GeneIDi4702262
KEGGiact:ACLA_096980

Similar proteinsi

Entry informationi

Entry nameiBGLE_ASPCL
AccessioniPrimary (citable) accession number: A1CMH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health