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A1CMH6 (BGLE_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-glucosidase E

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene names
Name:bglE
ORF Names:ACLA_096980
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1050 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Cellular componentCell membrane
Membrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10501050Probable beta-glucosidase E
PRO_0000394870

Regions

Topological domain1 – 174174Cytoplasmic Potential
Transmembrane175 – 19521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain196 – 1050855Extracellular Potential

Sites

Active site4581 By similarity

Amino acid modifications

Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation4301N-linked (GlcNAc...) Potential
Glycosylation5011N-linked (GlcNAc...) Potential
Glycosylation5401N-linked (GlcNAc...) Potential
Glycosylation6051N-linked (GlcNAc...) Potential
Glycosylation8841N-linked (GlcNAc...) Potential
Glycosylation9201N-linked (GlcNAc...) Potential
Glycosylation9291N-linked (GlcNAc...) Potential
Glycosylation9931N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CMH6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 0EE88C1BD581414E

FASTA1,050115,389
        10         20         30         40         50         60 
MPPPDSNPGS FRDHLKHDNK NNNSSTTSKG KQRYTPLHDS IPEEIASPRS ASASSSFDLD 

        70         80         90        100        110        120 
PDLENQSRND YKLRPLARSS STNGGHNYST AYIPVIRDEG DDVETYLDSI TEAEQELLSL 

       130        140        150        160        170        180 
SKQYDFADDS DDFDSDDDAA LRRKVQKQEQ RRRRERLKAK VWTPVKYARI WRRTLVVVIV 

       190        200        210        220        230        240 
ALALLVWGFL RFTAAQRQGP KVWPMLPSDS WFPSPKGGTL KHWEESYRKA QSLVRNMTLI 

       250        260        270        280        290        300 
EKVNITTGTG WQMGMCVGNT GPAELVKFPS LCLQDGPQGL RYADHVTAFP AGITTGSTWN 

       310        320        330        340        350        360 
RTLMRERGIA MGREARLKGV NVLLGPSIGP IGMMPAGGRN WEGFGSDPVL QGVAAAETIR 

       370        380        390        400        410        420 
GIQSNGVMAT AKHFLMNEQE HFRQPFEWGI STALSSNVGD RALHEVFAWP FAESIRADVA 

       430        440        450        460        470        480 
SVMCSYQMVN NSHACENSKL LNGILKDELG FQGFVQSDWL AQRSGINSAL GGLDMSMPGD 

       490        500        510        520        530        540 
GLHWTDGKSL WGRELTRAVL NTSIPMERLN DMVTRIVAAW YQFEQDEWER PPPEGNGGPN 

       550        560        570        580        590        600 
FSSWTGGDVG WLHAGSNDGL YAVVNQYIDA QGTGPEAHSI IARKVAAEGT VLLKNVDHTL 

       610        620        630        640        650        660 
PLSRNASGPS GVMRVGIYGD DAGPAQGPNA CPDRGCNQGT LATGWGSGTV DFPYLVSPLE 

       670        680        690        700        710        720 
ALETAWKTEV EMTAFLRNAV MPADVADKDL CLVFANADSG EGFISAGGIH GDRNDLFLQK 

       730        740        750        760        770        780 
GGDTLIRTVA SHCGEGQGKT VVVIHAVGPV VMESWIDLPG VHAVLLANLP GQESGNALMD 

       790        800        810        820        830        840 
VLFGDVDASG RLPYTIGKSL EEYGTEAQVL YEPNAPVPQV DLLDALFIDY RHFDQYNITP 

       850        860        870        880        890        900 
RFEFGFGLSY TTFKLKDLHV RSLQSKSRSP AARPAAAVSP PEYNTTLPDP ALALFPPGFQ 

       910        920        930        940        950        960 
PVYKYIYPYL PSLDGTAPAN YSYYPKDYNQ TQGPSPAGGG AGGNPALFQE MASVSVQVQN 

       970        980        990       1000       1010       1020 
TGDRKGQEVV QVYVSFPSDE KVKIDFPERV LRNFTKVELE PGERREVQMT LSRKDLSYWS 

      1030       1040       1050 
VREQNWVMPD GDFQIWVGRS SRDLPLQAKY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027058 Genomic DNA. Translation: EAW08763.1.
RefSeqXP_001270189.1. XM_001270188.1.

3D structure databases

ProteinModelPortalA1CMH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00009117.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00009341; CADACLAP00009117; CADACLAG00009341.
GeneID4702262.
KEGGact:ACLA_096980.

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000031215.
KOK05349.
OMAHYDRINS.
OrthoDBEOG7HMS8F.

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetSearch...

Entry information

Entry nameBGLE_ASPCL
AccessionPrimary (citable) accession number: A1CMH6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries