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A1CMH6

- BGLE_ASPCL

UniProt

A1CMH6 - BGLE_ASPCL

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Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei458 – 4581By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:ACLA_096980
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 174174CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei175 – 19521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini196 – 1050855ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10501050Probable beta-glucosidase EPRO_0000394870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi884 – 8841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi920 – 9201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi993 – 9931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00009117.

Structurei

3D structure databases

ProteinModelPortaliA1CMH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiHYDRINS.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

A1CMH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPPDSNPGS FRDHLKHDNK NNNSSTTSKG KQRYTPLHDS IPEEIASPRS
60 70 80 90 100
ASASSSFDLD PDLENQSRND YKLRPLARSS STNGGHNYST AYIPVIRDEG
110 120 130 140 150
DDVETYLDSI TEAEQELLSL SKQYDFADDS DDFDSDDDAA LRRKVQKQEQ
160 170 180 190 200
RRRRERLKAK VWTPVKYARI WRRTLVVVIV ALALLVWGFL RFTAAQRQGP
210 220 230 240 250
KVWPMLPSDS WFPSPKGGTL KHWEESYRKA QSLVRNMTLI EKVNITTGTG
260 270 280 290 300
WQMGMCVGNT GPAELVKFPS LCLQDGPQGL RYADHVTAFP AGITTGSTWN
310 320 330 340 350
RTLMRERGIA MGREARLKGV NVLLGPSIGP IGMMPAGGRN WEGFGSDPVL
360 370 380 390 400
QGVAAAETIR GIQSNGVMAT AKHFLMNEQE HFRQPFEWGI STALSSNVGD
410 420 430 440 450
RALHEVFAWP FAESIRADVA SVMCSYQMVN NSHACENSKL LNGILKDELG
460 470 480 490 500
FQGFVQSDWL AQRSGINSAL GGLDMSMPGD GLHWTDGKSL WGRELTRAVL
510 520 530 540 550
NTSIPMERLN DMVTRIVAAW YQFEQDEWER PPPEGNGGPN FSSWTGGDVG
560 570 580 590 600
WLHAGSNDGL YAVVNQYIDA QGTGPEAHSI IARKVAAEGT VLLKNVDHTL
610 620 630 640 650
PLSRNASGPS GVMRVGIYGD DAGPAQGPNA CPDRGCNQGT LATGWGSGTV
660 670 680 690 700
DFPYLVSPLE ALETAWKTEV EMTAFLRNAV MPADVADKDL CLVFANADSG
710 720 730 740 750
EGFISAGGIH GDRNDLFLQK GGDTLIRTVA SHCGEGQGKT VVVIHAVGPV
760 770 780 790 800
VMESWIDLPG VHAVLLANLP GQESGNALMD VLFGDVDASG RLPYTIGKSL
810 820 830 840 850
EEYGTEAQVL YEPNAPVPQV DLLDALFIDY RHFDQYNITP RFEFGFGLSY
860 870 880 890 900
TTFKLKDLHV RSLQSKSRSP AARPAAAVSP PEYNTTLPDP ALALFPPGFQ
910 920 930 940 950
PVYKYIYPYL PSLDGTAPAN YSYYPKDYNQ TQGPSPAGGG AGGNPALFQE
960 970 980 990 1000
MASVSVQVQN TGDRKGQEVV QVYVSFPSDE KVKIDFPERV LRNFTKVELE
1010 1020 1030 1040 1050
PGERREVQMT LSRKDLSYWS VREQNWVMPD GDFQIWVGRS SRDLPLQAKY
Length:1,050
Mass (Da):115,389
Last modified:January 23, 2007 - v1
Checksum:i0EE88C1BD581414E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027058 Genomic DNA. Translation: EAW08763.1.
RefSeqiXP_001270189.1. XM_001270188.1.

Genome annotation databases

EnsemblFungiiCADACLAT00009341; CADACLAP00009117; CADACLAG00009341.
GeneIDi4702262.
KEGGiact:ACLA_096980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027058 Genomic DNA. Translation: EAW08763.1 .
RefSeqi XP_001270189.1. XM_001270188.1.

3D structure databases

ProteinModelPortali A1CMH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00009117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00009341 ; CADACLAP00009117 ; CADACLAG00009341 .
GeneIDi 4702262.
KEGGi act:ACLA_096980.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
KOi K05349.
OMAi HYDRINS.
OrthoDBi EOG7HMS8F.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBGLE_ASPCL
AccessioniPrimary (citable) accession number: A1CMH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3