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A1CLZ5 (M2DH_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:ACLA_078730
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Mannitol 2-dehydrogenase
PRO_0000371538

Regions

Nucleotide binding37 – 4812NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A1CLZ5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: DEFE364514BACF0F

FASTA50256,505
        10         20         30         40         50         60 
MAPLKLNSRN LSQIFAAGKS LVKVPTYQRN GAVKEGIVHI GVGGFHRAHL AVYVDRLMQE 

        70         80         90        100        110        120 
QGVTDYAICG VGLQPFDSTM RDALASQDNL YTVIERSAKG SFAHVIGSIN SYLFAPDDRE 

       130        140        150        160        170        180 
AVIAKMANPD TRIVSLTITE SGYYYNENTH ELQKEHPDIQ FDLNPVNENK PRTTFGFLYA 

       190        200        210        220        230        240 
ALERRHRLGL KPFTVMSCDN MQKNGSITRH MLESFARQRN PKVAEWIAEE GAFPNAMVDR 

       250        260        270        280        290        300 
ITPQTSATDK TALAENFGIE DSWPVVTEPF MQWVIEDKFS DGRPPFEKIG VQVVKDVHAV 

       310        320        330        340        350        360 
EQFEKHKLRL LNGSHSAIGY PGQLAGFNYV HEVMEHPLFS KFVWQMMQQE VKPLLPEIPG 

       370        380        390        400        410        420 
VNIDDYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP SIAEAIWVTA PFRRLCFVAA 

       430        440        450        460        470        480 
AWFCYIKGID DSGKAFEVVD PMLNELQAKA RAGGTNPSEL LSIKNLFGDD LRTDPRFLKE 

       490        500 
VTKAMEDITR DGILKTLPKY ID 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027057 Genomic DNA. Translation: EAW09124.1.
RefSeqXP_001270550.1. XM_001270549.1.

3D structure databases

ProteinModelPortalA1CLZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00007234.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00007410; CADACLAP00007234; CADACLAG00007410.
GeneID4702636.
KEGGact:ACLA_078730.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000202982.
KOK00045.
OMAFEKVGVQ.
OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_ASPCL
AccessionPrimary (citable) accession number: A1CLZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families