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Protein

Mannitol 2-dehydrogenase

Gene

ACLA_078730

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 4812NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:ACLA_078730
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371538Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00007234.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000202982.
KOiK00045.
OMAiCHNPATG.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CLZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLKLNSRN LSQIFAAGKS LVKVPTYQRN GAVKEGIVHI GVGGFHRAHL
60 70 80 90 100
AVYVDRLMQE QGVTDYAICG VGLQPFDSTM RDALASQDNL YTVIERSAKG
110 120 130 140 150
SFAHVIGSIN SYLFAPDDRE AVIAKMANPD TRIVSLTITE SGYYYNENTH
160 170 180 190 200
ELQKEHPDIQ FDLNPVNENK PRTTFGFLYA ALERRHRLGL KPFTVMSCDN
210 220 230 240 250
MQKNGSITRH MLESFARQRN PKVAEWIAEE GAFPNAMVDR ITPQTSATDK
260 270 280 290 300
TALAENFGIE DSWPVVTEPF MQWVIEDKFS DGRPPFEKIG VQVVKDVHAV
310 320 330 340 350
EQFEKHKLRL LNGSHSAIGY PGQLAGFNYV HEVMEHPLFS KFVWQMMQQE
360 370 380 390 400
VKPLLPEIPG VNIDDYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP
410 420 430 440 450
SIAEAIWVTA PFRRLCFVAA AWFCYIKGID DSGKAFEVVD PMLNELQAKA
460 470 480 490 500
RAGGTNPSEL LSIKNLFGDD LRTDPRFLKE VTKAMEDITR DGILKTLPKY

ID
Length:502
Mass (Da):56,505
Last modified:January 23, 2007 - v1
Checksum:iDEFE364514BACF0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027057 Genomic DNA. Translation: EAW09124.1.
RefSeqiXP_001270550.1. XM_001270549.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007410; CADACLAP00007234; CADACLAG00007410.
GeneIDi4702636.
KEGGiact:ACLA_078730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027057 Genomic DNA. Translation: EAW09124.1.
RefSeqiXP_001270550.1. XM_001270549.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00007234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00007410; CADACLAP00007234; CADACLAG00007410.
GeneIDi4702636.
KEGGiact:ACLA_078730.

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000202982.
KOiK00045.
OMAiCHNPATG.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiM2DH_ASPCL
AccessioniPrimary (citable) accession number: A1CLZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.