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A1CLZ5

- M2DH_ASPCL

UniProt

A1CLZ5 - M2DH_ASPCL

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Protein

Mannitol 2-dehydrogenase

Gene
ACLA_078730
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 4812NAD By similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:ACLA_078730
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371538Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi5057.CADACLAP00007234.

Structurei

3D structure databases

ProteinModelPortaliA1CLZ5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000202982.
KOiK00045.
OMAiWLHFVRR.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CLZ5-1 [UniParc]FASTAAdd to Basket

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MAPLKLNSRN LSQIFAAGKS LVKVPTYQRN GAVKEGIVHI GVGGFHRAHL    50
AVYVDRLMQE QGVTDYAICG VGLQPFDSTM RDALASQDNL YTVIERSAKG 100
SFAHVIGSIN SYLFAPDDRE AVIAKMANPD TRIVSLTITE SGYYYNENTH 150
ELQKEHPDIQ FDLNPVNENK PRTTFGFLYA ALERRHRLGL KPFTVMSCDN 200
MQKNGSITRH MLESFARQRN PKVAEWIAEE GAFPNAMVDR ITPQTSATDK 250
TALAENFGIE DSWPVVTEPF MQWVIEDKFS DGRPPFEKIG VQVVKDVHAV 300
EQFEKHKLRL LNGSHSAIGY PGQLAGFNYV HEVMEHPLFS KFVWQMMQQE 350
VKPLLPEIPG VNIDDYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP 400
SIAEAIWVTA PFRRLCFVAA AWFCYIKGID DSGKAFEVVD PMLNELQAKA 450
RAGGTNPSEL LSIKNLFGDD LRTDPRFLKE VTKAMEDITR DGILKTLPKY 500
ID 502
Length:502
Mass (Da):56,505
Last modified:January 23, 2007 - v1
Checksum:iDEFE364514BACF0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027057 Genomic DNA. Translation: EAW09124.1.
RefSeqiXP_001270550.1. XM_001270549.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007410; CADACLAP00007234; CADACLAG00007410.
GeneIDi4702636.
KEGGiact:ACLA_078730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027057 Genomic DNA. Translation: EAW09124.1 .
RefSeqi XP_001270550.1. XM_001270549.1.

3D structure databases

ProteinModelPortali A1CLZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00007410 ; CADACLAP00007234 ; CADACLAG00007410 .
GeneIDi 4702636.
KEGGi act:ACLA_078730.

Phylogenomic databases

eggNOGi COG0246.
HOGENOMi HOG000202982.
KOi K00045.
OMAi WLHFVRR.
OrthoDBi EOG7PCJRT.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
PRINTSi PR00084. MTLDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiM2DH_ASPCL
AccessioniPrimary (citable) accession number: A1CLZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi