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A1CL96

- SSN3_ASPCL

UniProt

A1CL96 - SSN3_ASPCL

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Protein

Serine/threonine-protein kinase ssn3

Gene

ssn3

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711ATPPROSITE-ProRule annotation
Active sitei173 – 1731Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 559ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ssn3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:ssn3
Synonyms:cdk8
ORF Names:ACLA_041380
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Serine/threonine-protein kinase ssn3PRO_0000312933Add
BLAST

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00003993.

Structurei

3D structure databases

ProteinModelPortaliA1CL96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 368328Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK02208.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CL96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFGRNFPFFN SIGGFYPRDS LDPRKPSGTG YTSKVRVRDK YHIVGFISSG
60 70 80 90 100
TYGRVYKAIG KDGRKGEFAI KKFKPDKEGE IIQYTGLSQS AIREMSLCSE
110 120 130 140 150
LDHSNVVQLA EIILEDKCIF MVFEYTEHDL LQIIHHHTQP QRHAIPAPMI
160 170 180 190 200
KSILFQLLNG LLYLHTNWVL HRDLKPANIL VTSSGAVRIG DLGLARLFYK
210 220 230 240 250
PLNSLYSGDK VVVTIWYRAP ELLMGSRHYT PAVDLWAVGC IFAELLSLRP
260 270 280 290 300
IFKGEEAKMD SKKTVPFQRN QMMKIVEIMG LPRKETWPGL VAMPEFSQLQ
310 320 330 340 350
SLAMARGHLN RQSNLEGWYQ SCLKNNGYSP TSSAGTPGPE GFDLLSRLLE
360 370 380 390 400
YDPLKRISAQ EALEHPYFTT GTPITANCFA GYEGKYPHRR VTQDDNDIRS
410 420
GSLPGTKRSG LPDDSLMGRA AKRLKE
Length:426
Mass (Da):48,035
Last modified:January 15, 2008 - v2
Checksum:iF4C6DA86A1549D60
GO

Sequence cautioni

The sequence EAW09920.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027056 Genomic DNA. Translation: EAW09920.1. Sequence problems.
RefSeqiXP_001271346.1. XM_001271345.1.

Genome annotation databases

GeneIDi4702929.
KEGGiact:ACLA_041380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027056 Genomic DNA. Translation: EAW09920.1 . Sequence problems.
RefSeqi XP_001271346.1. XM_001271345.1.

3D structure databases

ProteinModelPortali A1CL96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00003993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4702929.
KEGGi act:ACLA_041380.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K02208.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiSSN3_ASPCL
AccessioniPrimary (citable) accession number: A1CL96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3