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A1CL96 (SSN3_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ssn3
EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:ssn3
Synonyms:cdk8
ORF Names:ACLA_041380
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence EAW09920.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Serine/threonine-protein kinase ssn3
PRO_0000312933

Regions

Domain41 – 368328Protein kinase
Nucleotide binding47 – 559ATP By similarity

Sites

Active site1731Proton acceptor By similarity
Binding site711ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1CL96 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: F4C6DA86A1549D60

FASTA42648,035
        10         20         30         40         50         60 
MFGRNFPFFN SIGGFYPRDS LDPRKPSGTG YTSKVRVRDK YHIVGFISSG TYGRVYKAIG 

        70         80         90        100        110        120 
KDGRKGEFAI KKFKPDKEGE IIQYTGLSQS AIREMSLCSE LDHSNVVQLA EIILEDKCIF 

       130        140        150        160        170        180 
MVFEYTEHDL LQIIHHHTQP QRHAIPAPMI KSILFQLLNG LLYLHTNWVL HRDLKPANIL 

       190        200        210        220        230        240 
VTSSGAVRIG DLGLARLFYK PLNSLYSGDK VVVTIWYRAP ELLMGSRHYT PAVDLWAVGC 

       250        260        270        280        290        300 
IFAELLSLRP IFKGEEAKMD SKKTVPFQRN QMMKIVEIMG LPRKETWPGL VAMPEFSQLQ 

       310        320        330        340        350        360 
SLAMARGHLN RQSNLEGWYQ SCLKNNGYSP TSSAGTPGPE GFDLLSRLLE YDPLKRISAQ 

       370        380        390        400        410        420 
EALEHPYFTT GTPITANCFA GYEGKYPHRR VTQDDNDIRS GSLPGTKRSG LPDDSLMGRA 


AKRLKE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS027056 Genomic DNA. Translation: EAW09920.1. Sequence problems.
RefSeqXP_001271346.1. XM_001271345.1.

3D structure databases

ProteinModelPortalA1CL96.
ModBaseSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00003993.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4702929.
KEGGact:ACLA_041380.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02208.
OrthoDBEOG470XRW.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_ASPCL
AccessionPrimary (citable) accession number: A1CL96
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 1, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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