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A1CJQ1

- DAPB_ASPCL

UniProt

A1CJQ1 - DAPB_ASPCL

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei753 – 7531Charge relay systemBy similarity
    Active sitei830 – 8301Charge relay systemBy similarity
    Active sitei863 – 8631Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:ACLA_035780
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412132Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi807 – 8071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00003660.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CJQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9191CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini113 – 914802VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei92 – 11221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000189891.
    KOiK01282.
    OMAiGEESYPE.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1CJQ1-1 [UniParc]FASTAAdd to Basket

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    MATFSDHETS EFLPMTRPRS TSSASQTSSD SGLSSEPAFQ EDQKQPFSAP    50
    NGTTGMDNGD RYRDLEDGEA EANEPFLASS KKAATGGRAR RIFWLLVLLC 100
    FGGWLLAFVL FLTGGRANYQ SASDALQAQE PESASGSTSS GKPVTLEQVL 150
    TGQWSPRYHA ITWVAGPNDE DGLLVEKGGG EQEGYLRVDD IQSRKNKDGK 200
    GGRVLMRKPI VHVDGKLVVP GNAWPSPDLK KVLLISDQEK NWRHSFTGKY 250
    WVLDVESQTA QPLDPSLPDG RVQLALWSPK SDAVIFVREN DVYLRKLSSD 300
    RVVTVTKDGG ENLFYGVPDW VYEEEVISGR SVTWWSNDAK YVAFFRTNES 350
    AVSDFPVDYF LSRPSGKKPD PGLENYPEVR QIKYPKAGAS NPVVDLQFYD 400
    VEKNEVFSVD VADDFDNDDR IIIEVVWASE GKVLVRSTNR ESDILKVFLI 450
    DTKSRTGRVV RTEDVASLDG GWVEPSQSTR FIPADPSNGR PDDGYIDTVP 500
    YKGYDHLAYF SPLDSPKGVM LTSGDWEVVD APAAVDLQRG LVYFVAAKEA 550
    PTERHIYRVQ LDGSNMTAIT DTSKPGYFGV SFSHGAGYAL LTYNGPSVPW 600
    QAIINTHGDE ITFEERIEEN PQLTSMIEAY ALPTEIYQNV TVDGFTLQVV 650
    ERRPPHFNPA KKYPVLFYLY GGPGSQTVDR KFSIDFQSYV ASSLGYIVVT 700
    VDGRGTGHIG RKARCIVRGN LGFYEARDQI ATAKIWAAKS YVDESRMAIW 750
    GWSFGGFMTL KTLELDAGET FQYGMAVAPV TDWRFYDSIY SERYMHTPQH 800
    NPSGYANSTI TDMAALTHPV RFLVMHGTAD DNVHLQNTLV LTDKLDLSNV 850
    KNYDLHFFPD SDHSIFFHNA HAMVYDRLSS WLVNAFNGEW HRIAHPVPGE 900
    SMWTRFKRSL PVLV 914
    Length:914
    Mass (Da):102,054
    Last modified:January 23, 2007 - v1
    Checksum:iB72E64B88D3C541D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027056 Genomic DNA. Translation: EAW09375.1.
    RefSeqiXP_001270801.1. XM_001270800.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00003740; CADACLAP00003660; CADACLAG00003740.
    GeneIDi4703117.
    KEGGiact:ACLA_035780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027056 Genomic DNA. Translation: EAW09375.1 .
    RefSeqi XP_001270801.1. XM_001270800.1.

    3D structure databases

    ProteinModelPortali A1CJQ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00003660.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00003740 ; CADACLAP00003660 ; CADACLAG00003740 .
    GeneIDi 4703117.
    KEGGi act:ACLA_035780.

    Phylogenomic databases

    HOGENOMi HOG000189891.
    KOi K01282.
    OMAi GEESYPE.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiDAPB_ASPCL
    AccessioniPrimary (citable) accession number: A1CJQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3