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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei753 – 7531Charge relay systemBy similarity
Active sitei830 – 8301Charge relay systemBy similarity
Active sitei863 – 8631Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:ACLA_035780
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini113 – 914802VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi807 – 8071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00003660.

Structurei

3D structure databases

ProteinModelPortaliA1CJQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiSIAYWQL.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CJQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATFSDHETS EFLPMTRPRS TSSASQTSSD SGLSSEPAFQ EDQKQPFSAP
60 70 80 90 100
NGTTGMDNGD RYRDLEDGEA EANEPFLASS KKAATGGRAR RIFWLLVLLC
110 120 130 140 150
FGGWLLAFVL FLTGGRANYQ SASDALQAQE PESASGSTSS GKPVTLEQVL
160 170 180 190 200
TGQWSPRYHA ITWVAGPNDE DGLLVEKGGG EQEGYLRVDD IQSRKNKDGK
210 220 230 240 250
GGRVLMRKPI VHVDGKLVVP GNAWPSPDLK KVLLISDQEK NWRHSFTGKY
260 270 280 290 300
WVLDVESQTA QPLDPSLPDG RVQLALWSPK SDAVIFVREN DVYLRKLSSD
310 320 330 340 350
RVVTVTKDGG ENLFYGVPDW VYEEEVISGR SVTWWSNDAK YVAFFRTNES
360 370 380 390 400
AVSDFPVDYF LSRPSGKKPD PGLENYPEVR QIKYPKAGAS NPVVDLQFYD
410 420 430 440 450
VEKNEVFSVD VADDFDNDDR IIIEVVWASE GKVLVRSTNR ESDILKVFLI
460 470 480 490 500
DTKSRTGRVV RTEDVASLDG GWVEPSQSTR FIPADPSNGR PDDGYIDTVP
510 520 530 540 550
YKGYDHLAYF SPLDSPKGVM LTSGDWEVVD APAAVDLQRG LVYFVAAKEA
560 570 580 590 600
PTERHIYRVQ LDGSNMTAIT DTSKPGYFGV SFSHGAGYAL LTYNGPSVPW
610 620 630 640 650
QAIINTHGDE ITFEERIEEN PQLTSMIEAY ALPTEIYQNV TVDGFTLQVV
660 670 680 690 700
ERRPPHFNPA KKYPVLFYLY GGPGSQTVDR KFSIDFQSYV ASSLGYIVVT
710 720 730 740 750
VDGRGTGHIG RKARCIVRGN LGFYEARDQI ATAKIWAAKS YVDESRMAIW
760 770 780 790 800
GWSFGGFMTL KTLELDAGET FQYGMAVAPV TDWRFYDSIY SERYMHTPQH
810 820 830 840 850
NPSGYANSTI TDMAALTHPV RFLVMHGTAD DNVHLQNTLV LTDKLDLSNV
860 870 880 890 900
KNYDLHFFPD SDHSIFFHNA HAMVYDRLSS WLVNAFNGEW HRIAHPVPGE
910
SMWTRFKRSL PVLV
Length:914
Mass (Da):102,054
Last modified:January 23, 2007 - v1
Checksum:iB72E64B88D3C541D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027056 Genomic DNA. Translation: EAW09375.1.
RefSeqiXP_001270801.1. XM_001270800.1.

Genome annotation databases

EnsemblFungiiCADACLAT00003740; CADACLAP00003660; CADACLAG00003740.
GeneIDi4703117.
KEGGiact:ACLA_035780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027056 Genomic DNA. Translation: EAW09375.1.
RefSeqiXP_001270801.1. XM_001270800.1.

3D structure databases

ProteinModelPortaliA1CJQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00003660.

Protein family/group databases

MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00003740; CADACLAP00003660; CADACLAG00003740.
GeneIDi4703117.
KEGGiact:ACLA_035780.

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiSIAYWQL.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDAPB_ASPCL
AccessioniPrimary (citable) accession number: A1CJQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.