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A1CJQ1

- DAPB_ASPCL

UniProt

A1CJQ1 - DAPB_ASPCL

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, ACLA_035780
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei753 – 7531Charge relay system By similarity
Active sitei830 – 8301Charge relay system By similarity
Active sitei863 – 8631Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:ACLA_035780
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei92 – 11221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini113 – 914802Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Probable dipeptidyl-aminopeptidase B
PRO_0000412132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi565 – 5651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi639 – 6391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi807 – 8071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00003660.

Structurei

3D structure databases

ProteinModelPortaliA1CJQ1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiGEESYPE.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CJQ1-1 [UniParc]FASTAAdd to Basket

« Hide

MATFSDHETS EFLPMTRPRS TSSASQTSSD SGLSSEPAFQ EDQKQPFSAP    50
NGTTGMDNGD RYRDLEDGEA EANEPFLASS KKAATGGRAR RIFWLLVLLC 100
FGGWLLAFVL FLTGGRANYQ SASDALQAQE PESASGSTSS GKPVTLEQVL 150
TGQWSPRYHA ITWVAGPNDE DGLLVEKGGG EQEGYLRVDD IQSRKNKDGK 200
GGRVLMRKPI VHVDGKLVVP GNAWPSPDLK KVLLISDQEK NWRHSFTGKY 250
WVLDVESQTA QPLDPSLPDG RVQLALWSPK SDAVIFVREN DVYLRKLSSD 300
RVVTVTKDGG ENLFYGVPDW VYEEEVISGR SVTWWSNDAK YVAFFRTNES 350
AVSDFPVDYF LSRPSGKKPD PGLENYPEVR QIKYPKAGAS NPVVDLQFYD 400
VEKNEVFSVD VADDFDNDDR IIIEVVWASE GKVLVRSTNR ESDILKVFLI 450
DTKSRTGRVV RTEDVASLDG GWVEPSQSTR FIPADPSNGR PDDGYIDTVP 500
YKGYDHLAYF SPLDSPKGVM LTSGDWEVVD APAAVDLQRG LVYFVAAKEA 550
PTERHIYRVQ LDGSNMTAIT DTSKPGYFGV SFSHGAGYAL LTYNGPSVPW 600
QAIINTHGDE ITFEERIEEN PQLTSMIEAY ALPTEIYQNV TVDGFTLQVV 650
ERRPPHFNPA KKYPVLFYLY GGPGSQTVDR KFSIDFQSYV ASSLGYIVVT 700
VDGRGTGHIG RKARCIVRGN LGFYEARDQI ATAKIWAAKS YVDESRMAIW 750
GWSFGGFMTL KTLELDAGET FQYGMAVAPV TDWRFYDSIY SERYMHTPQH 800
NPSGYANSTI TDMAALTHPV RFLVMHGTAD DNVHLQNTLV LTDKLDLSNV 850
KNYDLHFFPD SDHSIFFHNA HAMVYDRLSS WLVNAFNGEW HRIAHPVPGE 900
SMWTRFKRSL PVLV 914
Length:914
Mass (Da):102,054
Last modified:January 23, 2007 - v1
Checksum:iB72E64B88D3C541D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027056 Genomic DNA. Translation: EAW09375.1.
RefSeqiXP_001270801.1. XM_001270800.1.

Genome annotation databases

EnsemblFungiiCADACLAT00003740; CADACLAP00003660; CADACLAG00003740.
GeneIDi4703117.
KEGGiact:ACLA_035780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027056 Genomic DNA. Translation: EAW09375.1 .
RefSeqi XP_001270801.1. XM_001270800.1.

3D structure databases

ProteinModelPortali A1CJQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00003660.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00003740 ; CADACLAP00003660 ; CADACLAG00003740 .
GeneIDi 4703117.
KEGGi act:ACLA_035780.

Phylogenomic databases

HOGENOMi HOG000189891.
KOi K01282.
OMAi GEESYPE.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDAPB_ASPCL
AccessioniPrimary (citable) accession number: A1CJQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi