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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei753Charge relay systemBy similarity1
Active sitei830Charge relay systemBy similarity1
Active sitei863Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiaspcl-dapb DPP4N_Peptidase_S9
MEROPSiS09.006

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:ACLA_035780
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_035780

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 91CytoplasmicSequence analysisAdd BLAST91
Transmembranei92 – 112Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini113 – 914VacuolarSequence analysisAdd BLAST802

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121321 – 914Probable dipeptidyl-aminopeptidase BAdd BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi639N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1CJQ1

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00003660

Structurei

3D structure databases

ProteinModelPortaliA1CJQ1
SMRiA1CJQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891
KOiK01282
OMAiNHGIYGG
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

A1CJQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFSDHETS EFLPMTRPRS TSSASQTSSD SGLSSEPAFQ EDQKQPFSAP
60 70 80 90 100
NGTTGMDNGD RYRDLEDGEA EANEPFLASS KKAATGGRAR RIFWLLVLLC
110 120 130 140 150
FGGWLLAFVL FLTGGRANYQ SASDALQAQE PESASGSTSS GKPVTLEQVL
160 170 180 190 200
TGQWSPRYHA ITWVAGPNDE DGLLVEKGGG EQEGYLRVDD IQSRKNKDGK
210 220 230 240 250
GGRVLMRKPI VHVDGKLVVP GNAWPSPDLK KVLLISDQEK NWRHSFTGKY
260 270 280 290 300
WVLDVESQTA QPLDPSLPDG RVQLALWSPK SDAVIFVREN DVYLRKLSSD
310 320 330 340 350
RVVTVTKDGG ENLFYGVPDW VYEEEVISGR SVTWWSNDAK YVAFFRTNES
360 370 380 390 400
AVSDFPVDYF LSRPSGKKPD PGLENYPEVR QIKYPKAGAS NPVVDLQFYD
410 420 430 440 450
VEKNEVFSVD VADDFDNDDR IIIEVVWASE GKVLVRSTNR ESDILKVFLI
460 470 480 490 500
DTKSRTGRVV RTEDVASLDG GWVEPSQSTR FIPADPSNGR PDDGYIDTVP
510 520 530 540 550
YKGYDHLAYF SPLDSPKGVM LTSGDWEVVD APAAVDLQRG LVYFVAAKEA
560 570 580 590 600
PTERHIYRVQ LDGSNMTAIT DTSKPGYFGV SFSHGAGYAL LTYNGPSVPW
610 620 630 640 650
QAIINTHGDE ITFEERIEEN PQLTSMIEAY ALPTEIYQNV TVDGFTLQVV
660 670 680 690 700
ERRPPHFNPA KKYPVLFYLY GGPGSQTVDR KFSIDFQSYV ASSLGYIVVT
710 720 730 740 750
VDGRGTGHIG RKARCIVRGN LGFYEARDQI ATAKIWAAKS YVDESRMAIW
760 770 780 790 800
GWSFGGFMTL KTLELDAGET FQYGMAVAPV TDWRFYDSIY SERYMHTPQH
810 820 830 840 850
NPSGYANSTI TDMAALTHPV RFLVMHGTAD DNVHLQNTLV LTDKLDLSNV
860 870 880 890 900
KNYDLHFFPD SDHSIFFHNA HAMVYDRLSS WLVNAFNGEW HRIAHPVPGE
910
SMWTRFKRSL PVLV
Length:914
Mass (Da):102,054
Last modified:January 23, 2007 - v1
Checksum:iB72E64B88D3C541D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027056 Genomic DNA Translation: EAW09375.1
RefSeqiXP_001270801.1, XM_001270800.1

Genome annotation databases

EnsemblFungiiCADACLAT00003740; CADACLAP00003660; CADACLAG00003740
GeneIDi4703117
KEGGiact:ACLA_035780

Similar proteinsi

Entry informationi

Entry nameiDAPB_ASPCL
AccessioniPrimary (citable) accession number: A1CJQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health