Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1CIL1

- CREB_ASPCL

UniProt

A1CIL1 - CREB_ASPCL

Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641NucleophilePROSITE-ProRule annotation
    Active sitei420 – 4201Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. carbon catabolite repression of transcription Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
    Alternative name(s):
    Carbon catabolite repression protein B
    Deubiquitinating enzyme creB
    Ubiquitin thioesterase creB
    Ubiquitin-hydrolyzing enzyme creB
    Ubiquitin-specific-processing protease creB
    Gene namesi
    Name:creB
    ORF Names:ACLA_051880
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395677Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with creA, creC and qutD.By similarity

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00004413.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 469415USPAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili575 – 63561Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000192482.
    KOiK11872.
    OrthoDBiEOG7TF7JV.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1CIL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSFLRSFRN NAGSTTPSVG AVPAKKEVPI PPMTPLEKRL LDMGSIRGDG    50
    SDKFYGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLEAALA 100
    KSLRYPNPNA HLEAEAQAEK QRAANAQRPG MPPAQPQKPE DKDSPDYKKK 150
    MALQTLPLLE AQNNATSYGM SESLFTSLKD IFESVVGSQS RIGIVRPQQF 200
    LDVLRRDHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPAAIEKSLP 250
    APDHAETVDQ SASSGSKTPN TTRWVHELFE GTLTSETQCL TCEKVSQRDE 300
    IFLDLSVDLE QHSSVTSCLR KFSAEEMLCE RNKFHCDNCG GLQEAEKRMK 350
    IKRLPRILAL HLKRFKYTED LQRLQKLFHR VVYPYHLRLF NTTDDAEDPD 400
    RLYELYAVVV HIGGGPYHGH YVAIIKTEDR GWLLFDDELV EPVDKNYVRN 450
    FFGDKPGLAC AYVLFYQETT LEAVMKEQEQ ENMESNLSAT DTNEAALKPN 500
    GSSPSHLAHV HSASYIPSLE EHNRPNGLKR APTAPQLSTH HEHGDPESGA 550
    FSPVTATPPV PPIPEHLSAA PIPPKSDVQG KKERAREEKE RKAAEKEREK 600
    AEKLRRKEQE ARAKENQRRE EAELKAALEA SKASKAQEDR RQSPDHGKDK 650
    LGGGLSRLKR GSKSFSQRLG KDKETRSVSS LEAPPLPIPG HPISRDGPIP 700
    EQHQQQPDPK DDPFQDSHHP NKPMMKEDEQ ANHKDPKHER TGHGKWRSFS 750
    LRKKSFSILS 760
    Length:760
    Mass (Da):85,580
    Last modified:July 13, 2010 - v2
    Checksum:i6C4CD500504810F8
    GO

    Sequence cautioni

    The sequence EAW10716.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027054 Genomic DNA. Translation: EAW10716.1. Sequence problems.
    RefSeqiXP_001272142.1. XM_001272141.1.

    Genome annotation databases

    GeneIDi4703625.
    KEGGiact:ACLA_051880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027054 Genomic DNA. Translation: EAW10716.1 . Sequence problems.
    RefSeqi XP_001272142.1. XM_001272141.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00004413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4703625.
    KEGGi act:ACLA_051880.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000192482.
    KOi K11872.
    OrthoDBi EOG7TF7JV.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiCREB_ASPCL
    AccessioniPrimary (citable) accession number: A1CIL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3