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A1CIL1

- CREB_ASPCL

UniProt

A1CIL1 - CREB_ASPCL

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Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641NucleophilePROSITE-ProRule annotation
Active sitei420 – 4201Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. carbon catabolite repression of transcription Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.092.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:ACLA_051880
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395677Add
BLAST

Interactioni

Subunit structurei

Interacts with creA, creC and qutD.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00004413.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 469415USPAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili575 – 63561Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000192482.
KOiK11872.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CIL1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSFLRSFRN NAGSTTPSVG AVPAKKEVPI PPMTPLEKRL LDMGSIRGDG
60 70 80 90 100
SDKFYGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLEAALA
110 120 130 140 150
KSLRYPNPNA HLEAEAQAEK QRAANAQRPG MPPAQPQKPE DKDSPDYKKK
160 170 180 190 200
MALQTLPLLE AQNNATSYGM SESLFTSLKD IFESVVGSQS RIGIVRPQQF
210 220 230 240 250
LDVLRRDHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPAAIEKSLP
260 270 280 290 300
APDHAETVDQ SASSGSKTPN TTRWVHELFE GTLTSETQCL TCEKVSQRDE
310 320 330 340 350
IFLDLSVDLE QHSSVTSCLR KFSAEEMLCE RNKFHCDNCG GLQEAEKRMK
360 370 380 390 400
IKRLPRILAL HLKRFKYTED LQRLQKLFHR VVYPYHLRLF NTTDDAEDPD
410 420 430 440 450
RLYELYAVVV HIGGGPYHGH YVAIIKTEDR GWLLFDDELV EPVDKNYVRN
460 470 480 490 500
FFGDKPGLAC AYVLFYQETT LEAVMKEQEQ ENMESNLSAT DTNEAALKPN
510 520 530 540 550
GSSPSHLAHV HSASYIPSLE EHNRPNGLKR APTAPQLSTH HEHGDPESGA
560 570 580 590 600
FSPVTATPPV PPIPEHLSAA PIPPKSDVQG KKERAREEKE RKAAEKEREK
610 620 630 640 650
AEKLRRKEQE ARAKENQRRE EAELKAALEA SKASKAQEDR RQSPDHGKDK
660 670 680 690 700
LGGGLSRLKR GSKSFSQRLG KDKETRSVSS LEAPPLPIPG HPISRDGPIP
710 720 730 740 750
EQHQQQPDPK DDPFQDSHHP NKPMMKEDEQ ANHKDPKHER TGHGKWRSFS
760
LRKKSFSILS
Length:760
Mass (Da):85,580
Last modified:July 13, 2010 - v2
Checksum:i6C4CD500504810F8
GO

Sequence cautioni

The sequence EAW10716.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027054 Genomic DNA. Translation: EAW10716.1. Sequence problems.
RefSeqiXP_001272142.1. XM_001272141.1.

Genome annotation databases

GeneIDi4703625.
KEGGiact:ACLA_051880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027054 Genomic DNA. Translation: EAW10716.1 . Sequence problems.
RefSeqi XP_001272142.1. XM_001272141.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00004413.

Protein family/group databases

MEROPSi C19.092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4703625.
KEGGi act:ACLA_051880.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000192482.
KOi K11872.
OrthoDBi EOG7TF7JV.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiCREB_ASPCL
AccessioniPrimary (citable) accession number: A1CIL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3