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A1CIL1 (CREB_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB

EC=3.4.19.12
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene names
Name:creB
ORF Names:ACLA_051880
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with creA, creC and qutD By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence caution

The sequence EAW10716.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 760760Probable ubiquitin carboxyl-terminal hydrolase creB
PRO_0000395677

Regions

Domain55 – 469415USP
Coiled coil575 – 63561 Potential

Sites

Active site641Nucleophile By similarity
Active site4201Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A1CIL1 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: 6C4CD500504810F8

FASTA76085,580
        10         20         30         40         50         60 
MGSFLRSFRN NAGSTTPSVG AVPAKKEVPI PPMTPLEKRL LDMGSIRGDG SDKFYGMENY 

        70         80         90        100        110        120 
GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLEAALA KSLRYPNPNA HLEAEAQAEK 

       130        140        150        160        170        180 
QRAANAQRPG MPPAQPQKPE DKDSPDYKKK MALQTLPLLE AQNNATSYGM SESLFTSLKD 

       190        200        210        220        230        240 
IFESVVGSQS RIGIVRPQQF LDVLRRDHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK 

       250        260        270        280        290        300 
QPAAIEKSLP APDHAETVDQ SASSGSKTPN TTRWVHELFE GTLTSETQCL TCEKVSQRDE 

       310        320        330        340        350        360 
IFLDLSVDLE QHSSVTSCLR KFSAEEMLCE RNKFHCDNCG GLQEAEKRMK IKRLPRILAL 

       370        380        390        400        410        420 
HLKRFKYTED LQRLQKLFHR VVYPYHLRLF NTTDDAEDPD RLYELYAVVV HIGGGPYHGH 

       430        440        450        460        470        480 
YVAIIKTEDR GWLLFDDELV EPVDKNYVRN FFGDKPGLAC AYVLFYQETT LEAVMKEQEQ 

       490        500        510        520        530        540 
ENMESNLSAT DTNEAALKPN GSSPSHLAHV HSASYIPSLE EHNRPNGLKR APTAPQLSTH 

       550        560        570        580        590        600 
HEHGDPESGA FSPVTATPPV PPIPEHLSAA PIPPKSDVQG KKERAREEKE RKAAEKEREK 

       610        620        630        640        650        660 
AEKLRRKEQE ARAKENQRRE EAELKAALEA SKASKAQEDR RQSPDHGKDK LGGGLSRLKR 

       670        680        690        700        710        720 
GSKSFSQRLG KDKETRSVSS LEAPPLPIPG HPISRDGPIP EQHQQQPDPK DDPFQDSHHP 

       730        740        750        760 
NKPMMKEDEQ ANHKDPKHER TGHGKWRSFS LRKKSFSILS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027054 Genomic DNA. Translation: EAW10716.1. Sequence problems.
RefSeqXP_001272142.1. XM_001272141.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00004413.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4703625.
KEGGact:ACLA_051880.

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000192482.
KOK11872.
OrthoDBEOG7TF7JV.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCREB_ASPCL
AccessionPrimary (citable) accession number: A1CIL1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries