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Protein

Mitochondrial glycine transporter

Gene

ACLA_051330

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:ACLA_051330
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_051330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 53Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei81 – 107Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei141 – 166Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei194 – 217Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei241 – 267Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei296 – 314Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789241 – 334Mitochondrial glycine transporterAdd BLAST334

Structurei

3D structure databases

ProteinModelPortaliA1CIF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 106Solcar 1UniRule annotationAdd BLAST85
Repeati135 – 219Solcar 2UniRule annotationAdd BLAST85
Repeati237 – 321Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A1CIF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNATTYVV SPAPLKTTST SSKTTFHFVA GLCSGLTSSI LLQPADLLKT
60 70 80 90 100
RVQQSHKSAS LLPTLKTILS SPHPIRSLWR GTLPSALRTG FGSALYFTSL
110 120 130 140 150
NALRQGIAQT RTPLAIASAS SDGKARTSSS ALPKLSNWAN LATGAIARVA
160 170 180 190 200
AGFVMMPVTV LKVRYESDYY AYRSLVGAGR DIVRTEGVRG LFSGFGATAA
210 220 230 240 250
RDAPYAGLYV LFYEQLKRRL ASVASSEYSE QPLKTSSSSS INFVSGGLAA
260 270 280 290 300
GLATAITNPF DAVKTRLQLM PGKYGNMMRA VRLMIHEDGV RSLFGGLGLR
310 320 330
ITRKALSSAL AWTVYEELIL RAEGHWAEQG KINL
Length:334
Mass (Da):35,774
Last modified:January 23, 2007 - v1
Checksum:iAA93138A097AA8A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027054 Genomic DNA Translation: EAW10661.1
RefSeqiXP_001272087.1, XM_001272086.1

Genome annotation databases

EnsemblFungiiCADACLAT00004543; CADACLAP00004442; CADACLAG00004543
GeneIDi4703666
KEGGiact:ACLA_051330

Similar proteinsi

Entry informationi

Entry nameiS2538_ASPCL
AccessioniPrimary (citable) accession number: A1CIF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health