ID   PRTT_ASPCL              Reviewed;         622 AA.
AC   A1CHV7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   RecName: Full=Transcriptional activator of proteases prtT;
DE   AltName: Full=Zn(2)-C6 zinc finger-containing protein prtT;
GN   Name=prtT; ORFNames=ACLA_049340;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Transcription factor required for protein utilization and
CC       degradation. Regulates transcription of major secreted proteases (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the prtT family. {ECO:0000305}.
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DR   EMBL; DS027054; EAW10462.1; -; Genomic_DNA.
DR   RefSeq; XP_001271888.1; XM_001271887.1.
DR   AlphaFoldDB; A1CHV7; -.
DR   EnsemblFungi; EAW10462; EAW10462; ACLA_049340.
DR   GeneID; 4703912; -.
DR   KEGG; act:ACLA_049340; -.
DR   VEuPathDB; FungiDB:ACLA_049340; -.
DR   eggNOG; ENOG502QU5T; Eukaryota.
DR   HOGENOM; CLU_030102_0_0_1; -.
DR   OMA; EMTSMMR; -.
DR   OrthoDB; 2100713at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd12148; fungal_TF_MHR; 1.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; Zn(2)-C6 fungal-type DNA-binding domain; 1.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   InterPro; IPR001138; Zn2Cys6_DnaBD.
DR   PANTHER; PTHR31845; FINGER DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR31845:SF34; TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..622
FT                   /note="Transcriptional activator of proteases prtT"
FT                   /id="PRO_0000407030"
FT   DNA_BIND        54..83
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   622 AA;  70510 MW;  DF638C4A0D263433 CRC64;
     MTRTTTLEEV KFEIPTWDNN NHIEVADGSG RSESNASGDT IRPKGRIRRS MTACNTCRKL
     KTRCDLDPRG HACRRCLSLR IECKLPDTAE RFQDNASMWS DATAAIPSIE ERLNSLERSM
     TEMTSMMRQM VDRSPSISGS SVSLLTRSGL TEETASVEGS QPSFIAPRPI RLIQELQSDF
     LGEPNVLPAE SRSLSESFSN GVLDPKLSLK LIQLFVEHFG SWVSIDSPSD IHNDLRPTDP
     LLYRTACLLA SRYVPGIPSS VIQAEYLQIR HAAVNILWNS QPMKYETLQA LTLLSLWPTT
     IQKEAPMDSW LLSGISINHA IISFDFLNHA PAELIVDNDM VAKLRLWNAL CLTQLQFAIG
     NARPFHIQQR YLEHCPRLLE HPAATFDDGK MVAEIQLYLV TSKLQNDPHR MRSAEIEYEE
     IERWKMEWAH LLTGEQHSTL ELNLWYCQLL LYRTAMKCQW ESEPLVSEVL RNARLIISKF
     LLVRFSTALG FVDQTYYIVG YAALNLCDFN PMDPLIDQVQ TFLLHLSPNE DHIAYRFSYT
     ISELKRRCTA CPNPNSAVKG AFGDARKLNL GQLHFMPQVL DTMMGDYSAL EQLMPEVSPH
     SLPDMLNNVT GELQAGYRTA IL
//