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A1CHP1

- DPP4_ASPCL

UniProt

A1CHP1 - DPP4_ASPCL

Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei616 – 6161Charge relay systemBy similarity
    Active sitei693 – 6931Charge relay systemBy similarity
    Active sitei728 – 7281Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
    Alternative name(s):
    Dipeptidyl peptidase IV
    Short name:
    DPP IV
    Short name:
    DppIV
    Gene namesi
    Name:dpp4
    ORF Names:ACLA_048680
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 768751Probable dipeptidyl peptidase 4PRO_0000397809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA1CHP1.

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00004923.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CHP1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000189891.
    KOiK01278.
    OMAiHERVIFR.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CHP1-1 [UniParc]FASTAAdd to Basket

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    MKLGKWSVLL LVGCTAAIDI PRKPFPPTGS GHKRLTFNET VVKPVIAPSS    50
    TAVEWISTAE DGDYVFQDSD GSLKIQSIVT NHTQTLVPAD KVPDDAYSYW 100
    IHPNLSSVLW ATNYTKQYRY SYFASYYIQD LQSFKLAPLA SNQAGDIQYA 150
    NWSPTGDAIA FVRANNVYVW TAKSTTQITT DGSADLFNGV PDWIYEEEIL 200
    GDRHALWFSP DAEYLAFLRF NETGVPTFRV PYYMDNEEVA PPYPRELELR 250
    YPKVSQTNPT VEVRLLSRAT GEVSSVSIKA FNATDLVIGE VAWLTETHSQ 300
    VAVKAFNRVQ DQQKVVTVDV LSLKTKTISE RDGTDGWLDN ALSITYIGQI 350
    GDSKAEYYID ISDESGWAHL WLFPVAGGRP MALTKGEWEV TAILSIDKQR 400
    QLVYYLSTQH HSTERHVYSV SWKTFTATPL VDDTVAAVWS ASFSSQGGYY 450
    ILSYRGPDVP YQELYAINST KPLCTITSNA AVYDVLKQYT LPKISYFELR 500
    LPSGETLNVM QRLPVSFSPR KKYPILFTPY GGPGAQEVSK AWQSQTFKSY 550
    IASDPELEFV TWTVDNRGTG YKGRRFRGQV AKQLGRLEAQ DQVWAAQQAA 600
    KLPFIDAEHI AIWGWSYGGY LTGKVIETDS GVFSLGVLTA PVSDWRFYDS 650
    MYTERYMKTL QENANGYNAS AIWDVAGYKN VRGGVLIQHG TGDDNVHFQN 700
    AAALVDRLVG EGVSPDKLQV QWFTDSDHGI RYHGGSVFLY RQLAKRLYEE 750
    KHRKKSEGHQ WSKRSLEF 768
    Length:768
    Mass (Da):86,453
    Last modified:January 23, 2007 - v1
    Checksum:i124A589592FEF512
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027054 Genomic DNA. Translation: EAW10396.1.
    RefSeqiXP_001271822.1. XM_001271821.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00005024; CADACLAP00004923; CADACLAG00005024.
    GeneIDi4704099.
    KEGGiact:ACLA_048680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027054 Genomic DNA. Translation: EAW10396.1 .
    RefSeqi XP_001271822.1. XM_001271821.1.

    3D structure databases

    ProteinModelPortali A1CHP1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00004923.

    Protein family/group databases

    MEROPSi S09.008.

    Proteomic databases

    PRIDEi A1CHP1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00005024 ; CADACLAP00004923 ; CADACLAG00005024 .
    GeneIDi 4704099.
    KEGGi act:ACLA_048680.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000189891.
    KOi K01278.
    OMAi HERVIFR.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiDPP4_ASPCL
    AccessioniPrimary (citable) accession number: A1CHP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3