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Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei616 – 6161Charge relay systemBy similarity
Active sitei693 – 6931Charge relay systemBy similarity
Active sitei728 – 7281Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:ACLA_048680
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 768751Probable dipeptidyl peptidase 4PRO_0000397809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1CHP1.

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00004923.

Structurei

3D structure databases

ProteinModelPortaliA1CHP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiWIDINEP.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CHP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGKWSVLL LVGCTAAIDI PRKPFPPTGS GHKRLTFNET VVKPVIAPSS
60 70 80 90 100
TAVEWISTAE DGDYVFQDSD GSLKIQSIVT NHTQTLVPAD KVPDDAYSYW
110 120 130 140 150
IHPNLSSVLW ATNYTKQYRY SYFASYYIQD LQSFKLAPLA SNQAGDIQYA
160 170 180 190 200
NWSPTGDAIA FVRANNVYVW TAKSTTQITT DGSADLFNGV PDWIYEEEIL
210 220 230 240 250
GDRHALWFSP DAEYLAFLRF NETGVPTFRV PYYMDNEEVA PPYPRELELR
260 270 280 290 300
YPKVSQTNPT VEVRLLSRAT GEVSSVSIKA FNATDLVIGE VAWLTETHSQ
310 320 330 340 350
VAVKAFNRVQ DQQKVVTVDV LSLKTKTISE RDGTDGWLDN ALSITYIGQI
360 370 380 390 400
GDSKAEYYID ISDESGWAHL WLFPVAGGRP MALTKGEWEV TAILSIDKQR
410 420 430 440 450
QLVYYLSTQH HSTERHVYSV SWKTFTATPL VDDTVAAVWS ASFSSQGGYY
460 470 480 490 500
ILSYRGPDVP YQELYAINST KPLCTITSNA AVYDVLKQYT LPKISYFELR
510 520 530 540 550
LPSGETLNVM QRLPVSFSPR KKYPILFTPY GGPGAQEVSK AWQSQTFKSY
560 570 580 590 600
IASDPELEFV TWTVDNRGTG YKGRRFRGQV AKQLGRLEAQ DQVWAAQQAA
610 620 630 640 650
KLPFIDAEHI AIWGWSYGGY LTGKVIETDS GVFSLGVLTA PVSDWRFYDS
660 670 680 690 700
MYTERYMKTL QENANGYNAS AIWDVAGYKN VRGGVLIQHG TGDDNVHFQN
710 720 730 740 750
AAALVDRLVG EGVSPDKLQV QWFTDSDHGI RYHGGSVFLY RQLAKRLYEE
760
KHRKKSEGHQ WSKRSLEF
Length:768
Mass (Da):86,453
Last modified:January 23, 2007 - v1
Checksum:i124A589592FEF512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027054 Genomic DNA. Translation: EAW10396.1.
RefSeqiXP_001271822.1. XM_001271821.1.

Genome annotation databases

EnsemblFungiiCADACLAT00005024; CADACLAP00004923; CADACLAG00005024.
GeneIDi4704099.
KEGGiact:ACLA_048680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027054 Genomic DNA. Translation: EAW10396.1.
RefSeqiXP_001271822.1. XM_001271821.1.

3D structure databases

ProteinModelPortaliA1CHP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00004923.

Protein family/group databases

MEROPSiS09.008.

Proteomic databases

PRIDEiA1CHP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00005024; CADACLAP00004923; CADACLAG00005024.
GeneIDi4704099.
KEGGiact:ACLA_048680.

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiWIDINEP.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDPP4_ASPCL
AccessioniPrimary (citable) accession number: A1CHP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.