A1CHP1 (DPP4_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dipeptidyl peptidase 4
EC=3.4.14.5

Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV

Gene names

Name:	dpp4
ORF Names:	ACLA_048680

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus clavatus

Protein attributes

Sequence length	768 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the peptidase S9B family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 768	751	Probable dipeptidyl peptidase 4		PRO_0000397809
Sites
	Active site	616	1	Charge relay system By similarity
	Active site	693	1	Charge relay system By similarity
	Active site	728	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	81	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	468	1	N-linked (GlcNAc...) Potential
	Glycosylation	668	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A1CHP1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 124A589592FEF512	FASTA	768	86,453
	10 20 30 40 50 60 MKLGKWSVLL LVGCTAAIDI PRKPFPPTGS GHKRLTFNET VVKPVIAPSS TAVEWISTAE 70 80 90 100 110 120 DGDYVFQDSD GSLKIQSIVT NHTQTLVPAD KVPDDAYSYW IHPNLSSVLW ATNYTKQYRY 130 140 150 160 170 180 SYFASYYIQD LQSFKLAPLA SNQAGDIQYA NWSPTGDAIA FVRANNVYVW TAKSTTQITT 190 200 210 220 230 240 DGSADLFNGV PDWIYEEEIL GDRHALWFSP DAEYLAFLRF NETGVPTFRV PYYMDNEEVA 250 260 270 280 290 300 PPYPRELELR YPKVSQTNPT VEVRLLSRAT GEVSSVSIKA FNATDLVIGE VAWLTETHSQ 310 320 330 340 350 360 VAVKAFNRVQ DQQKVVTVDV LSLKTKTISE RDGTDGWLDN ALSITYIGQI GDSKAEYYID 370 380 390 400 410 420 ISDESGWAHL WLFPVAGGRP MALTKGEWEV TAILSIDKQR QLVYYLSTQH HSTERHVYSV 430 440 450 460 470 480 SWKTFTATPL VDDTVAAVWS ASFSSQGGYY ILSYRGPDVP YQELYAINST KPLCTITSNA 490 500 510 520 530 540 AVYDVLKQYT LPKISYFELR LPSGETLNVM QRLPVSFSPR KKYPILFTPY GGPGAQEVSK 550 560 570 580 590 600 AWQSQTFKSY IASDPELEFV TWTVDNRGTG YKGRRFRGQV AKQLGRLEAQ DQVWAAQQAA 610 620 630 640 650 660 KLPFIDAEHI AIWGWSYGGY LTGKVIETDS GVFSLGVLTA PVSDWRFYDS MYTERYMKTL 670 680 690 700 710 720 QENANGYNAS AIWDVAGYKN VRGGVLIQHG TGDDNVHFQN AAALVDRLVG EGVSPDKLQV 730 740 750 760 QWFTDSDHGI RYHGGSVFLY RQLAKRLYEE KHRKKSEGHQ WSKRSLEF

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027054 Genomic DNA. Translation: EAW10396.1.
RefSeq	XP_001271822.1. XM_001271821.1.
3D structure databases
ProteinModelPortal	A1CHP1.
ModBase	Search...
Protein family/group databases
MEROPS	S09.008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00005024; CADACLAP00004923; CADACLAG00005024.
GeneID	4704099.
KEGG	act:ACLA_048680.
Phylogenomic databases
eggNOG	COG1506.
HOGENOM	HOG000189891.
KO	K01278.
OrthoDB	EOG4HB1TN.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPP4_ASPCL

Accession

Primary (citable) accession number: A1CHP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	January 23, 2007
Last modified:	June 13, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program