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A1CHP1 (DPP4_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl peptidase 4

EC=3.4.14.5
Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV
Gene names
Name:dpp4
ORF Names:ACLA_048680
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length768 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 768751Probable dipeptidyl peptidase 4
PRO_0000397809

Sites

Active site6161Charge relay system By similarity
Active site6931Charge relay system By similarity
Active site7281Charge relay system By similarity

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...) Potential
Glycosylation2821N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential
Glycosylation6681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CHP1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 124A589592FEF512

FASTA76886,453
        10         20         30         40         50         60 
MKLGKWSVLL LVGCTAAIDI PRKPFPPTGS GHKRLTFNET VVKPVIAPSS TAVEWISTAE 

        70         80         90        100        110        120 
DGDYVFQDSD GSLKIQSIVT NHTQTLVPAD KVPDDAYSYW IHPNLSSVLW ATNYTKQYRY 

       130        140        150        160        170        180 
SYFASYYIQD LQSFKLAPLA SNQAGDIQYA NWSPTGDAIA FVRANNVYVW TAKSTTQITT 

       190        200        210        220        230        240 
DGSADLFNGV PDWIYEEEIL GDRHALWFSP DAEYLAFLRF NETGVPTFRV PYYMDNEEVA 

       250        260        270        280        290        300 
PPYPRELELR YPKVSQTNPT VEVRLLSRAT GEVSSVSIKA FNATDLVIGE VAWLTETHSQ 

       310        320        330        340        350        360 
VAVKAFNRVQ DQQKVVTVDV LSLKTKTISE RDGTDGWLDN ALSITYIGQI GDSKAEYYID 

       370        380        390        400        410        420 
ISDESGWAHL WLFPVAGGRP MALTKGEWEV TAILSIDKQR QLVYYLSTQH HSTERHVYSV 

       430        440        450        460        470        480 
SWKTFTATPL VDDTVAAVWS ASFSSQGGYY ILSYRGPDVP YQELYAINST KPLCTITSNA 

       490        500        510        520        530        540 
AVYDVLKQYT LPKISYFELR LPSGETLNVM QRLPVSFSPR KKYPILFTPY GGPGAQEVSK 

       550        560        570        580        590        600 
AWQSQTFKSY IASDPELEFV TWTVDNRGTG YKGRRFRGQV AKQLGRLEAQ DQVWAAQQAA 

       610        620        630        640        650        660 
KLPFIDAEHI AIWGWSYGGY LTGKVIETDS GVFSLGVLTA PVSDWRFYDS MYTERYMKTL 

       670        680        690        700        710        720 
QENANGYNAS AIWDVAGYKN VRGGVLIQHG TGDDNVHFQN AAALVDRLVG EGVSPDKLQV 

       730        740        750        760 
QWFTDSDHGI RYHGGSVFLY RQLAKRLYEE KHRKKSEGHQ WSKRSLEF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027054 Genomic DNA. Translation: EAW10396.1.
RefSeqXP_001271822.1. XM_001271821.1.

3D structure databases

ProteinModelPortalA1CHP1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00004923.

Protein family/group databases

MEROPSS09.008.

Proteomic databases

PRIDEA1CHP1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00005024; CADACLAP00004923; CADACLAG00005024.
GeneID4704099.
KEGGact:ACLA_048680.

Phylogenomic databases

eggNOGCOG1506.
HOGENOMHOG000189891.
KOK01278.
OMAHERVIFR.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPP4_ASPCL
AccessionPrimary (citable) accession number: A1CHP1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries