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A1CHP1

- DPP4_ASPCL

UniProt

A1CHP1 - DPP4_ASPCL

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Protein

Probable dipeptidyl peptidase 4

Gene
dpp4, ACLA_048680
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei616 – 6161Charge relay system By similarity
Active sitei693 – 6931Charge relay system By similarity
Active sitei728 – 7281Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:ACLA_048680
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 768751Probable dipeptidyl peptidase 4PRO_0000397809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi221 – 2211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi282 – 2821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi668 – 6681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1CHP1.

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00004923.

Structurei

3D structure databases

ProteinModelPortaliA1CHP1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiHERVIFR.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CHP1-1 [UniParc]FASTAAdd to Basket

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MKLGKWSVLL LVGCTAAIDI PRKPFPPTGS GHKRLTFNET VVKPVIAPSS    50
TAVEWISTAE DGDYVFQDSD GSLKIQSIVT NHTQTLVPAD KVPDDAYSYW 100
IHPNLSSVLW ATNYTKQYRY SYFASYYIQD LQSFKLAPLA SNQAGDIQYA 150
NWSPTGDAIA FVRANNVYVW TAKSTTQITT DGSADLFNGV PDWIYEEEIL 200
GDRHALWFSP DAEYLAFLRF NETGVPTFRV PYYMDNEEVA PPYPRELELR 250
YPKVSQTNPT VEVRLLSRAT GEVSSVSIKA FNATDLVIGE VAWLTETHSQ 300
VAVKAFNRVQ DQQKVVTVDV LSLKTKTISE RDGTDGWLDN ALSITYIGQI 350
GDSKAEYYID ISDESGWAHL WLFPVAGGRP MALTKGEWEV TAILSIDKQR 400
QLVYYLSTQH HSTERHVYSV SWKTFTATPL VDDTVAAVWS ASFSSQGGYY 450
ILSYRGPDVP YQELYAINST KPLCTITSNA AVYDVLKQYT LPKISYFELR 500
LPSGETLNVM QRLPVSFSPR KKYPILFTPY GGPGAQEVSK AWQSQTFKSY 550
IASDPELEFV TWTVDNRGTG YKGRRFRGQV AKQLGRLEAQ DQVWAAQQAA 600
KLPFIDAEHI AIWGWSYGGY LTGKVIETDS GVFSLGVLTA PVSDWRFYDS 650
MYTERYMKTL QENANGYNAS AIWDVAGYKN VRGGVLIQHG TGDDNVHFQN 700
AAALVDRLVG EGVSPDKLQV QWFTDSDHGI RYHGGSVFLY RQLAKRLYEE 750
KHRKKSEGHQ WSKRSLEF 768
Length:768
Mass (Da):86,453
Last modified:January 23, 2007 - v1
Checksum:i124A589592FEF512
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027054 Genomic DNA. Translation: EAW10396.1.
RefSeqiXP_001271822.1. XM_001271821.1.

Genome annotation databases

EnsemblFungiiCADACLAT00005024; CADACLAP00004923; CADACLAG00005024.
GeneIDi4704099.
KEGGiact:ACLA_048680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027054 Genomic DNA. Translation: EAW10396.1 .
RefSeqi XP_001271822.1. XM_001271821.1.

3D structure databases

ProteinModelPortali A1CHP1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00004923.

Protein family/group databases

MEROPSi S09.008.

Proteomic databases

PRIDEi A1CHP1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00005024 ; CADACLAP00004923 ; CADACLAG00005024 .
GeneIDi 4704099.
KEGGi act:ACLA_048680.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01278.
OMAi HERVIFR.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDPP4_ASPCL
AccessioniPrimary (citable) accession number: A1CHP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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