Reviewed, UniProtKB/Swiss-Prot A1CHL6 (ATG1_ASPCL)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	ACLA_048410

Organism

Aspergillus clavatus [Complete proteome]

Taxonomic identifier

5057 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	928 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 928	928	Serine/threonine-protein kinase atg1		PRO_0000317787
Regions
	Domain	6 – 315	310	Protein kinase
	Nucleotide binding	12 – 20	9	ATP By similarity
Sites
	Active site	149	1	Proton acceptor By similarity
	Binding site	35	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1CHL6-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: F833AB1702209C5C	FASTA	928	101,306
	10 20 30 40 50 60 MSLGRYTRLD EIGRGSFATV YQGVHTKTGT YVAIKSVNLS KLNKKLKENL SSEIHILKGL 70 80 90 100 110 120 YHPHIVALID CQETSSHIHL VMEYCALGDL SLFIKRRDTL GDHRYTRDMI AKYPNPPGGA 130 140 150 160 170 180 LNEVVVRHFL KQLSSALKFL RDRNLIHRDI KPQNLLLCPS PSSYRSGAGS GAATVVPFKG 190 200 210 220 230 240 CEDSFNPATG VDSLPLLKIA DFGFARSLPA TSLAETLCGS PLYMAPEILR YEKYDAKADL 250 260 270 280 290 300 WSVGTVLYEM VVGKPPFRAT NHVELLRKIE KGEDRIKFPE DNPASDAIKA LIRALLKRNP 310 320 330 340 350 360 VERLNFPEFF ENEVITGPIP GLLADDQPSI SRHRSVDPGT TEVPPRPDSR SGTSVPSGTR 370 380 390 400 410 420 REREVNREDV YSPRSSPRNQ KPSTPPTSTP MRRVGSTDRP PSAPKESEPP MAYPQRPNAV 430 440 450 460 470 480 SHATAPGRQE LLDRKATTTA IERQRSRNTY SEGSPRLDQP ADKLKEEQER AAQDVAFERD 490 500 510 520 530 540 YVVVEKRAVE VNAFADELAH SPRIQGGLSR AAQAGAISRR ATVQGATPTL SSPQTTTGKA 550 560 570 580 590 600 MQVFSGRSRA DSTHHRQASY ERRYGQSPTS ATSAISKALN MASGRLFGMG FSPPLTITKG 610 620 630 640 650 660 GRSPPLAYNP FPAYPTAHGS LMIIGDGAKS QVALDEDTKT VQVIEECATR SDVVYGFAEV 670 680 690 700 710 720 KYKQLIPLAP SIQTDPSAKS NMSGVRDTAG STDGDLTVDA TVTLSEEALV LYVKALSLLA 730 740 750 760 770 780 KSMDIAGVWW TRKNRGETFG DPVMSRADTT GALVGTRINN VVQWVRNRFN EVLEKAEFVR 790 800 810 820 830 840 LKLIEGQKRL PPDHPSHPSN HSVTSSLGAG STDIVVSSGV TAEKLMYDRA LEMSRAAAIN 850 860 870 880 890 900 ELTGEDLAGC EIAYVTAIRM LEAVLEDDEV PGLGPGKVDT SKDMYDGVPA EDRQVVVKLV 910 920 SSIRGRLQAL RKKLAILAKR APTASVNV

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DS027054 Genomic DNA. Translation: EAW10371.1.
RefSeq	XP_001271797.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4704065.
Enzyme and pathway databases
BRENDA	2.7.11.1. 18580.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_ASPCL

Accession

Primary (citable) accession number: A1CHL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)