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Protein

Elongation factor G, mitochondrial

Gene

mef1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

Pathwayi: polypeptide chain elongation

This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi108 – 1158GTPUniRule annotation
Nucleotide bindingi184 – 1885GTPUniRule annotation
Nucleotide bindingi238 – 2414GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G, mitochondrialUniRule annotation
Short name:
EF-GmtUniRule annotation
Alternative name(s):
Elongation factor G 1, mitochondrialUniRule annotation
Short name:
mEF-G 1UniRule annotation
Elongation factor G1UniRule annotation
Gene namesi
Name:mef1
ORF Names:ACLA_047470
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_047470.

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionUniRule annotationAdd
BLAST
Chaini25 – 801777Elongation factor G, mitochondrialPRO_0000385556Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 386288tr-type GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000231585.
KOiK02355.
OMAiKVTLHFG.
OrthoDBiEOG092C1RRE.

Family and domain databases

CDDicd01434. EFG_mtEFG1_IV. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CHC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCPSLARLP HRAISGLTRL PVRLQSQTFL YQRCASTAAL RSPTAGPAYQ
60 70 80 90 100
SILNRHNLQR RNASAAAAAV LEAAASNPDA LTQEAIIDNL DPVEATRLSR
110 120 130 140 150
IRNIGIAAHI DSGKTTCTER ILFYTGRIKA IHEVRGRDNV GAKMDSMDLE
160 170 180 190 200
REKGITIQSA ATFCDWVKKE DDGREEKYHI NLIDTPGHID FTIEVERALR
210 220 230 240 250
VLDGAVMILC AVSGVQSQTI TVDRQMRRYN VPRISFINKM DRMGANPFKA
260 270 280 290 300
VDQINSKLKI PAAAVQVPIG AEDEFEGVVD LIRMKSIYNH GPSGEEIVIK
310 320 330 340 350
DEIPEKVKSV VEERRRMLIE TLADVDDEIA ELFLDEKEPT QEQLKAAIRR
360 370 380 390 400
ATVGLKFTPV FMGTALSNKS VQPMLDGVID YLPNPSEIEN LALDQKRNEA
410 420 430 440 450
SVKLVPYNSQ PFVGLAFKLE ESNFGQLTYI RVYQGTLRKG ANVFNARNNK
460 470 480 490 500
KVKIPRIVRM HSNEMEEVSE IGAGEICAVF GVDCASGDSF TDGQLGYTMT
510 520 530 540 550
SMFVPEPVIS LSIKPKNNKD SANFSKAMAR FQREDPTFRV TYDAESEQTL
560 570 580 590 600
ISGMGELHLD IYIERMRREY RVDCETGPPQ VAYRETIGNK VEFDHLLKKQ
610 620 630 640 650
SGGPGDYARV VGWMEPTDKL EENKFEEQIV GGSISEKFLF ACEKGFNLAC
660 670 680 690 700
EKGPLIGHKV LGTRMVINDG ATHMTDSSEM SFKNATQQAF RKAFMESNPS
710 720 730 740 750
VLEPMMKTVV TAPSEFQGDV ISLLNKRNAT INDTETGVDE FTVYADCSLN
760 770 780 790 800
GMFGFSSHLR AATQGKGEYT MEFSHYEKAQ PQLQKELIQK YLKAQADRHK

K
Length:801
Mass (Da):89,442
Last modified:January 23, 2007 - v1
Checksum:iBD321F6A2A984B2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027054 Genomic DNA. Translation: EAW10278.1.
RefSeqiXP_001271704.1. XM_001271703.1.

Genome annotation databases

EnsemblFungiiCADACLAT00004456; CADACLAP00004355; CADACLAG00004456.
GeneIDi4704201.
KEGGiact:ACLA_047470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027054 Genomic DNA. Translation: EAW10278.1.
RefSeqiXP_001271704.1. XM_001271703.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00004456; CADACLAP00004355; CADACLAG00004456.
GeneIDi4704201.
KEGGiact:ACLA_047470.

Organism-specific databases

EuPathDBiFungiDB:ACLA_047470.

Phylogenomic databases

HOGENOMiHOG000231585.
KOiK02355.
OMAiKVTLHFG.
OrthoDBiEOG092C1RRE.

Enzyme and pathway databases

UniPathwayiUPA00345.

Family and domain databases

CDDicd01434. EFG_mtEFG1_IV. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFGM_ASPCL
AccessioniPrimary (citable) accession number: A1CHC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.