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A1CGC6

- MANA_ASPCL

UniProt

A1CGC6 - MANA_ASPCL

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Protein

Probable mannan endo-1,4-beta-mannosidase A

Gene

manA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Proton donorBy similarity
Active sitei287 – 2871NucleophileBy similarity

GO - Molecular functioni

  1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannan endo-1,4-beta-mannosidase A (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase A
Gene namesi
Name:manA
Synonyms:man1
ORF Names:ACLA_066420
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 360342Probable mannan endo-1,4-beta-mannosidase APRO_0000393701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1CGC6.
SMRiA1CGC6. Positions 27-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3934.
HOGENOMiHOG000169951.
OMAiNESAQMA.
OrthoDBiEOG7M3J90.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CGC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSQILTFA SLLSGALAAP GKPHGKPGFA STSGLQFSID GQTGYFAGSN
60 70 80 90 100
SYWIGFLTNK ADVDIGFNDV NTVPGEGTVY YQLHANGKST INTGANGLQR
110 120 130 140 150
MDYVVKSAEK HGIKLIINFV NNWDDYGGMN AYVKGYGAAD HNDFYSNAKI
160 170 180 190 200
QKAYRQYIRA VVSRYTKSDA VFAWELANEP RCKGCDTDVL YDWIKSTSEY
210 220 230 240 250
IKSLDAKHMV CIGDEGFGLE TLSDGSYPFT YVEGSDFARN LAIPTIDFGT
260 270 280 290 300
FHLYPDSWGT SHEWGNLWTQ AHGAACQAAG KPCLFEEYGV TSDHCALETP
310 320 330 340 350
WQKTSLNTTG VSADLYWQYG DTLSSGPSPN DGHTVYYGTD DFKCMVTDHV
360
AAIKAKQGWV
Length:360
Mass (Da):39,457
Last modified:January 23, 2007 - v1
Checksum:iB25067154F8DBF70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027053 Genomic DNA. Translation: EAW11006.1.
RefSeqiXP_001272432.1. XM_001272431.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006214; CADACLAP00006059; CADACLAG00006214.
GeneIDi4704555.
KEGGiact:ACLA_066420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027053 Genomic DNA. Translation: EAW11006.1 .
RefSeqi XP_001272432.1. XM_001272431.1.

3D structure databases

ProteinModelPortali A1CGC6.
SMRi A1CGC6. Positions 27-353.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00006214 ; CADACLAP00006059 ; CADACLAG00006214 .
GeneIDi 4704555.
KEGGi act:ACLA_066420.

Phylogenomic databases

eggNOGi COG3934.
HOGENOMi HOG000169951.
OMAi NESAQMA.
OrthoDBi EOG7M3J90.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiMANA_ASPCL
AccessioniPrimary (citable) accession number: A1CGC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3