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A1CGC6 (MANA_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable mannan endo-1,4-beta-mannosidase A
EC=3.2.1.78
Alternative name(s):
Endo-beta-1,4-mannanase A
Gene names
Name:manA
Synonyms:man1
ORF Names:ACLA_066420
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans By similarity.

Catalytic activity

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannan endo-1,4-beta-mannosidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 360342Probable mannan endo-1,4-beta-mannosidase A
PRO_0000393701

Sites

Active site1791Proton donor By similarity
Active site2871Nucleophile By similarity

Amino acid modifications

Glycosylation3071N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CGC6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: B25067154F8DBF70

FASTA36039,457
        10         20         30         40         50         60 
MKLSQILTFA SLLSGALAAP GKPHGKPGFA STSGLQFSID GQTGYFAGSN SYWIGFLTNK 

        70         80         90        100        110        120 
ADVDIGFNDV NTVPGEGTVY YQLHANGKST INTGANGLQR MDYVVKSAEK HGIKLIINFV 

       130        140        150        160        170        180 
NNWDDYGGMN AYVKGYGAAD HNDFYSNAKI QKAYRQYIRA VVSRYTKSDA VFAWELANEP 

       190        200        210        220        230        240 
RCKGCDTDVL YDWIKSTSEY IKSLDAKHMV CIGDEGFGLE TLSDGSYPFT YVEGSDFARN 

       250        260        270        280        290        300 
LAIPTIDFGT FHLYPDSWGT SHEWGNLWTQ AHGAACQAAG KPCLFEEYGV TSDHCALETP 

       310        320        330        340        350        360 
WQKTSLNTTG VSADLYWQYG DTLSSGPSPN DGHTVYYGTD DFKCMVTDHV AAIKAKQGWV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS027053 Genomic DNA. Translation: EAW11006.1.
RefSeqXP_001272432.1. XM_001272431.1.

3D structure databases

ProteinModelPortalA1CGC6.
SMRA1CGC6. Positions 27-353.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00006214; CADACLAP00006059; CADACLAG00006214.
GeneID4704555.
KEGGact:ACLA_066420.

Phylogenomic databases

eggNOGCOG3934.
HOGENOMHOG000169951.
OrthoDBEOG44BF9Z.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
PROSITEPS00659. GLYCOSYL_HYDROL_F5. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANA_ASPCL
AccessionPrimary (citable) accession number: A1CGC6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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