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A1CGA8

- MANBB_ASPCL

UniProt

A1CGA8 - MANBB_ASPCL

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Protein

Beta-mannosidase B

Gene

mndB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers manobiose over mannotriose and has no activity against polymeric mannan. Is also severly restricetd by galactosyl substitutions at the +1 subsite (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei432 – 4321Proton donorBy similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. mannan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase B (EC:3.2.1.25)
Alternative name(s):
Mannanase B
Short name:
Mannase B
Gene namesi
Name:mndB
ORF Names:ACLA_066240
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Beta-mannosidase BPRO_0000394651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi717 – 7171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi723 – 7231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00006175.

Structurei

3D structure databases

ProteinModelPortaliA1CGA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000186861.
KOiK01192.
OMAiSWGLGYY.
OrthoDBiEOG7NSB9Q.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view]
PANTHERiPTHR10066:SF12. PTHR10066:SF12. 1 hit.
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CGA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALQRFPLS KGWSFKDSED KSEDAWMPVP VVPSVVQQDL QANNKLKDPY
60 70 80 90 100
IGFNELETRW VNEKSWTYKT TFQKPAVPAG SAIFLAFDGL DTFATVKLDG
110 120 130 140 150
NVILESDNMF LAHRLDVTKA LEAEGDHSLE IDFDCAFLRA KELRKQDSKH
160 170 180 190 200
NWASFNGDPS RLSVRKSQYH WGWDWGPVLM TAGIWREVRL EVYTARVADL
210 220 230 240 250
WTDVQLASDH QNAQITAFAE VESVNSDAHK ARFTLSLHGQ ELGREEVSVS
260 270 280 290 300
EDGSAKVSFD VKSPSLWWPH GYGDATLYEV SVSLVKDQDE VHQVSKKFGI
310 320 330 340 350
RTAEVVQQPD KHGKSFFFRV NGVDIFCGGS CWIPADNYLP SVTADRYRKW
360 370 380 390 400
IELMVHGRQV MIRVWGGGNY EDDSFYDACD ELGVLVWQDF MFGCGNYPTW
410 420 430 440 450
PNLLESIRKE SVYNVRRLRH HPSIVVWVGN NEDYQVQESA GLTYDFEDKN
460 470 480 490 500
PENWLKTDFP ARYIYEKILP EVVEEYSPST FYHPGSPWGD GKTTSDPTVG
510 520 530 540 550
DMHQWNVWHG TQEKYQIFDT LGGRFNSEFG MEAFPHMSTI DYFVENEADK
560 570 580 590 600
FPQSHVLDFH NKADGHERRI ATYLVENLRT ATDLETHVYL TQVVQAETMM
610 620 630 640 650
FGYRGWRRQW GDERHCGGAL LWQLNDCWPT ISWAIVDYFL RPKPAFYAVA
660 670 680 690 700
RVLNPIAVGV RREHHDWSVT HAQPPKTSKF ELWVASSLQK EVQGTVELRF
710 720 730 740 750
LSINTGLEVR ERIVHENVSI VPNGTTNLIV DGLIDYKVHP EPHVLAVRIW
760 770 780 790 800
VNGELVARDV DWPQPFKYLD LSNRGLEVKL VSESENEQTL LLSAQKPVKC
810 820 830 840
LVFEEREGVR ISDSAIDIVP GDEQRVTIKG MKPGDAPLKY KFLGQ
Length:845
Mass (Da):96,760
Last modified:January 23, 2007 - v1
Checksum:i41EE1CB40C7719C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027053 Genomic DNA. Translation: EAW10988.1.
RefSeqiXP_001272414.1. XM_001272413.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006330; CADACLAP00006175; CADACLAG00006330.
GeneIDi4704556.
KEGGiact:ACLA_066240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027053 Genomic DNA. Translation: EAW10988.1 .
RefSeqi XP_001272414.1. XM_001272413.1.

3D structure databases

ProteinModelPortali A1CGA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00006175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00006330 ; CADACLAP00006175 ; CADACLAG00006330 .
GeneIDi 4704556.
KEGGi act:ACLA_066240.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000186861.
KOi K01192.
OMAi SWGLGYY.
OrthoDBi EOG7NSB9Q.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view ]
PANTHERi PTHR10066:SF12. PTHR10066:SF12. 1 hit.
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiMANBB_ASPCL
AccessioniPrimary (citable) accession number: A1CGA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to clade A beta-mannosidases, which are likely secreted, clade B proteins appear to be intracellular.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3