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Protein

Probable endo-beta-1,4-glucanase celB

Gene

celB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates (By similarity).By similarity

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei215NucleophileBy similarity1
Active sitei220Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-beta-1,4-glucanase celB (EC:3.2.1.4)
Short name:
Endoglucanase celB
Alternative name(s):
Carboxymethylcellulase celB
Cellulase B
Gene namesi
Name:celB
ORF Names:ACLA_066030
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_066030.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000039515319 – 418Probable endo-beta-1,4-glucanase celBAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1CG87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000182210.
KOiK19357.
OMAiHTNGSEL.
OrthoDBiEOG092C29WB.

Family and domain databases

CDDicd07999. GH7_CBH_EG. 1 hit.
Gene3Di2.70.100.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamiPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSiPR00734. GLHYDRLASE7.
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CG87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRTFAVTAL ALLPLVAAQQ IGSTKEVHPQ LTTYKCTSQG GCVKQNTSIV
60 70 80 90 100
LDSGSHWIHA KGGEVSCTTS SGLDPALCPD KETCAENCVV EGITDYSQYG
110 120 130 140 150
VQTRGDAMLL REYIKQNNQT KAPSPRVYLL DEDGENYSML RLLNQEFTFD
160 170 180 190 200
VDVSKLPCGM NGALYFSEMS ASGGRSALNP AGAAYGTGYC DAQCYTNAWI
210 220 230 240 250
NGEANTAKAG LCCQEMDIWE ANARANAFTP HPCNSTGLLG CAGDECNSVC
260 270 280 290 300
DKAGCGFNPY ALGARDYYGT AMTVDTTKPF TVVTQFLTAD NSTTGALREI
310 320 330 340 350
RRLYVQAGQV IQNAVVKVDG RTVNSITEPY CASQGVFEGL GGLRRMGEAL
360 370 380 390 400
GRGMVLSMSI WNDAGGFMHW LDSGNSGPCS STEGDPSLIE NKYPDTAVTF
410
SKIRWGDLGT TFATRRLH
Length:418
Mass (Da):44,827
Last modified:January 23, 2007 - v1
Checksum:iC9607BB9C58EC80B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027053 Genomic DNA. Translation: EAW10967.1.
RefSeqiXP_001272393.1. XM_001272392.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006346; CADACLAP00006191; CADACLAG00006346.
GeneIDi4704573.
KEGGiact:ACLA_066030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027053 Genomic DNA. Translation: EAW10967.1.
RefSeqiXP_001272393.1. XM_001272392.1.

3D structure databases

ProteinModelPortaliA1CG87.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00006346; CADACLAP00006191; CADACLAG00006346.
GeneIDi4704573.
KEGGiact:ACLA_066030.

Organism-specific databases

EuPathDBiFungiDB:ACLA_066030.

Phylogenomic databases

HOGENOMiHOG000182210.
KOiK19357.
OMAiHTNGSEL.
OrthoDBiEOG092C29WB.

Family and domain databases

CDDicd07999. GH7_CBH_EG. 1 hit.
Gene3Di2.70.100.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamiPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSiPR00734. GLHYDRLASE7.
SUPFAMiSSF49899. SSF49899. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCELB_ASPCL
AccessioniPrimary (citable) accession number: A1CG87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.