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Protein

Probable endo-beta-1,4-glucanase celB

Gene

celB

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates (By similarity).By similarity

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei215NucleophileBy similarity1
Active sitei220Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-beta-1,4-glucanase celB (EC:3.2.1.4)
Short name:
Endoglucanase celB
Alternative name(s):
Carboxymethylcellulase celB
Cellulase B
Gene namesi
Name:celB
ORF Names:ACLA_066030
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_066030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000039515319 – 418Probable endo-beta-1,4-glucanase celBAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00006191

Structurei

3D structure databases

ProteinModelPortaliA1CG87
SMRiA1CG87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000182210
KOiK19357
OMAiQERCIAD
OrthoDBiEOG092C29WB

Family and domain databases

CDDicd07999 GH7_CBH_EG, 1 hit
Gene3Di2.70.100.10, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001722 Glyco_hydro_7
IPR037019 Glyco_hydro_7_sf
PANTHERiPTHR33753 PTHR33753, 1 hit
PfamiView protein in Pfam
PF00840 Glyco_hydro_7, 1 hit
PRINTSiPR00734 GLHYDRLASE7
SUPFAMiSSF49899 SSF49899, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CG87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRTFAVTAL ALLPLVAAQQ IGSTKEVHPQ LTTYKCTSQG GCVKQNTSIV
60 70 80 90 100
LDSGSHWIHA KGGEVSCTTS SGLDPALCPD KETCAENCVV EGITDYSQYG
110 120 130 140 150
VQTRGDAMLL REYIKQNNQT KAPSPRVYLL DEDGENYSML RLLNQEFTFD
160 170 180 190 200
VDVSKLPCGM NGALYFSEMS ASGGRSALNP AGAAYGTGYC DAQCYTNAWI
210 220 230 240 250
NGEANTAKAG LCCQEMDIWE ANARANAFTP HPCNSTGLLG CAGDECNSVC
260 270 280 290 300
DKAGCGFNPY ALGARDYYGT AMTVDTTKPF TVVTQFLTAD NSTTGALREI
310 320 330 340 350
RRLYVQAGQV IQNAVVKVDG RTVNSITEPY CASQGVFEGL GGLRRMGEAL
360 370 380 390 400
GRGMVLSMSI WNDAGGFMHW LDSGNSGPCS STEGDPSLIE NKYPDTAVTF
410
SKIRWGDLGT TFATRRLH
Length:418
Mass (Da):44,827
Last modified:January 23, 2007 - v1
Checksum:iC9607BB9C58EC80B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027053 Genomic DNA Translation: EAW10967.1
RefSeqiXP_001272393.1, XM_001272392.1

Genome annotation databases

EnsemblFungiiCADACLAT00006346; CADACLAP00006191; CADACLAG00006346
GeneIDi4704573
KEGGiact:ACLA_066030

Similar proteinsi

Entry informationi

Entry nameiCELB_ASPCL
AccessioniPrimary (citable) accession number: A1CG87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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