A1CFB3 (ATG26_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sterol 3-beta-glucosyltransferase
EC=2.4.1.173

Alternative name(s):
Autophagy-related protein 26

Gene names

Name:	atg26
ORF Names:	ACLA_092600

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	1406 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in decane metabolism and autophagy. Involved in the biosynthesis of sterol glucoside By similarity.
Catalytic activity	UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 28 family. Contains 2 GRAM domains. Contains 1 PH domain.

Ontologies

Keywords
Biological process	Autophagy Lipid synthesis Protein transport Steroid biosynthesis Sterol biosynthesis Transport
Cellular component	Cytoplasm Membrane
Domain	Repeat
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW lipid glycosylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sterol 3-beta-glucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1406	1406	Sterol 3-beta-glucosyltransferase		PRO_0000318039
Regions
	Domain	236 – 286	51	GRAM 1
	Domain	286 – 385	100	PH
	Domain	730 – 796	67	GRAM 2

Sequences

	Sequence		Length	Mass (Da)
	A1CFB3 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: E9CFD7129621A573	FASTA	1,406	157,611
	10 20 30 40 50 60 MRPFLDDAKR RVDRRLSASK QSISTSRLLP SVLPDRFKDN HDAQVDFTAP PGGVGSREGH 70 80 90 100 110 120 MQYMQQSIFS MIAAVGSRSD FHARFDESSD SDGETEGRSQ TESPVKKVLG SSNPVNSQTE 130 140 150 160 170 180 QRSGSQTSRK SEKDQSSRGR HHRRTISDHK FLRPFKTSSK PEPDTEPSTG DERLRVTLPR 190 200 210 220 230 240 RPRSTTPRAA PILSRMVEAQ AQFDSKTPSA GRSQNSSQES SIHSSHESST SPLSTRLMEM 250 260 270 280 290 300 FDFNKPEKVL VEYACSLLQS MLLQGYMYVT EGHICFYAYL PRKSTVAIKS GYLHKRGRKN 310 320 330 340 350 360 PKYNRYWFSL KGDVLSYYAD PSNLYFPSGH VDLRYGISAS LAESKEKGRE PKEFQVSTDQ 370 380 390 400 410 420 RTYHFRADSS VSAKEWVKAL QKVIFRTHNE GDSVKVSFPI ENIIDIEESP MMDFADTFKI 430 440 450 460 470 480 RVVEDDDSYA IDEYFFSFFD SGREALTLLK SLVNENASGH SSRTLSPHAD RSPRSDRTRR 490 500 510 520 530 540 SRNRWSLTSG TSQPGNGSAD THRKRSASTS HLSLGPDAIP TSPVTRHQDP SESILNSFEQ 550 560 570 580 590 600 GTESSAVWQS MEDGAESASQ ILHRSDVFQS PTIHNLDKRA CSDERSGRRQ AGGTARSTLT 610 620 630 640 650 660 HVNANKDGSP GEYSKLGNDG KPDREIRHVI HELDQETQGP SKPGPGAPTL NELVKAGTYP 670 680 690 700 710 720 LQRAAGFAEY LRTRSKQMSN LLASESMGYI EKVSGMWVGG RRHYGEAEDV LPDDQAVDPE 730 740 750 760 770 780 DKEDGCNYGD RFRAHFALPS TEKLQATYFA YLHRVLPLYG KIYISQKKLC FRSLIPGTRT 790 800 810 820 830 840 KMILPLKDVE NVEKEKGFRF GYQGLVIIIR GHEELFFEFR TSDARDDCAV TLHQHLESVK 850 860 870 880 890 900 YLAESGLLAE QEKDESEAAM AEHRMLQEAR LDDYGENDIP PLNESSGLHP IFDDPRASIV 910 920 930 940 950 960 NFKPAESLRI TCLTIGSRGD VQPYIALCKG LLAEGHKPKI ATHAEFEPWV RRHGIDFAPV 970 980 990 1000 1010 1020 DGDPAELMRI CVENGMFTYS FLKEASQKFR GWIDDLLSSA WASCQDSDLL IESPSAMAGI 1030 1040 1050 1060 1070 1080 HIAEALRIPY FRAFTMPWSR TRAYPHAFAV PEHKMGGAYN YITYVMFDNV FWKAIAGQVN 1090 1100 1110 1120 1130 1140 RWRKNELGLK ATTLDKMQPN KVPFLYNYSP SVVPPPLDYP DWIRITGYWF LNEGVDWTPP 1150 1160 1170 1180 1190 1200 VDLSAFIQRA REDDKKIVYI GFGSIVVSDP SALTRTVIES VQKADVRCIL SKGWSDRLGD 1210 1220 1230 1240 1250 1260 PSSAKTEVPL PPEIFQIQAA PHDWLFAQVD AAVHHGGAGT TGASLRAGIP TIIKPFFGDQ 1270 1280 1290 1300 1310 1320 FFFGSRIEDL GVGICMKKLN VSVFSRALWE ATHSERMIIR ARDLGAKIRD EDGVATAIQA 1330 1340 1350 1360 1370 1380 IYRDLEHAKT LAQQRSIASS TPFSPTPSAK NTAEQGDDDV EDSEEWTFVG DDNEMDMSRR 1390 1400 MRDRAISDAE MLPDRLLTNS IHGAGR

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027052 Genomic DNA. Translation: EAW11562.1.
RefSeq	XP_001272988.1. XM_001272987.1.
3D structure databases
ProteinModelPortal	A1CFB3.
ModBase	Search...
Protein-protein interaction databases
STRING	A1CFB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00008491; CADACLAP00008281; CADACLAG00008491.
GeneID	4705245.
KEGG	act:ACLA_092600.
Phylogenomic databases
GeneTree	EFGT00050000002910.
OrthoDB	EOG48KVK8.
Family and domain databases
InterPro	IPR004276. Glyco_trans_28. IPR004182. GRAM. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR002213. UDP_glucos_trans. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
KO	K05841.
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF03033. Glyco_transf_28. 1 hit. PF02893. GRAM. 2 hits. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00568. GRAM. 2 hits. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG26_ASPCL

Accession

Primary (citable) accession number: A1CFB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program