A1CEK6 (HSE1_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Class E vacuolar protein-sorting machinery protein hse1

Gene names

Name:	hse1
ORF Names:	ACLA_089980

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus clavatus

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) By similarity.
Subunit structure	Component of the ESCRT-0 complex composed of HSE1 and VPS27 By similarity.
Subcellular location	Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the STAM family. Contains 1 SH3 domain. Contains 1 UIM (ubiquitin-interacting motif) repeat. Contains 1 VHS domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endosome Membrane
Domain	SH3 domain
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular_component	endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 599	599	Class E vacuolar protein-sorting machinery protein hse1		PRO_0000292486
Regions
	Domain	16 – 145	130	VHS
	Repeat	162 – 181	20	UIM
	Domain	215 – 274	60	SH3
	Compositional bias	372 – 575	204	Pro-rich
	Compositional bias	441 – 508	68	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	A1CEK6 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 587E0488CE3587C8	FASTA	599	66,319
	10 20 30 40 50 60 MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM IKRLAHRNAN 70 80 90 100 110 120 VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR NTHQQVKSKI LERMHDWTRM 130 140 150 160 170 180 FSSNPDFGIM EQAYMKLKTQ NPNLQPPSKP VKKEITQADR QKEEEELQMA LALSIREKSD 190 200 210 220 230 240 AGPAPQAESS APASAPVSQT QAAAPQAVPS GTSAATVSRV RALFDFQPSE PGELQFRKGD 250 260 270 280 290 300 IIAVLESVYK DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEADV FGQIKNVEKL 310 320 330 340 350 360 LTLLSTRSSE LNVQDNEEIT ALYHSTLAIR PKLIELIGKY SQKKDEFTQL NEKFIKARRD 370 380 390 400 410 420 YESLLEASMS HPPQPQYARP GQPPYGYPAP TGPHGYPQGA PQPDPQRYFS PRPQDQTHMY 430 440 450 460 470 480 PPTSQSPDPR GRTPPAGPTM QQQQQQPPAE SFQPMHHRPE STYDNPQELG TSVYDSPVEY 490 500 510 520 530 540 PPANQRFQYP PGASAPPGVH QQLQQQQQEY SPSNYSPEDT TNPPTANFPP QPQQSQLPYP 550 560 570 580 590 TGPAGHQAPP SHQPPPVPGG ASKPSPYPSL TPGAPSAGEY QAYNPSQASA SSNPASFYR

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027052 Genomic DNA. Translation: EAW11305.1.
RefSeq	XP_001272731.1. XM_001272730.1.
3D structure databases
ProteinModelPortal	A1CEK6.
SMR	A1CEK6. Positions 220-269.
ModBase	Search...
Protein-protein interaction databases
STRING	5057.CADACLAP00008355.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00008565; CADACLAP00008355; CADACLAG00008565.
GeneID	4705069.
KEGG	act:ACLA_089980.
Phylogenomic databases
eggNOG	NOG309509.
HOGENOM	HOG000048362.
KO	K04705.
OrthoDB	EOG4KM2BT.
Family and domain databases
Gene3D	1.25.40.90. 1 hit.
InterPro	IPR008942. ENTH_VHS. IPR001452. SH3_domain. IPR013315. Spectrin_alpha_SH3. IPR002014. VHS. IPR018205. VHS_subgr. [Graphical view]
Pfam	PF00018. SH3_1. 1 hit. PF00790. VHS. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN. PR01887. SPECTRNALPHA.
SMART	SM00326. SH3. 1 hit. SM00288. VHS. 1 hit. [Graphical view]
SUPFAM	SSF48464. ENTH_VHS. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. PS50330. UIM. False negative. PS50179. VHS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSE1_ASPCL

Accession

Primary (citable) accession number: A1CEK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program