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A1CEK6

- HSE1_ASPCL

UniProt

A1CEK6 - HSE1_ASPCL

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Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:ACLA_089980
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Class E vacuolar protein-sorting machinery protein hse1PRO_0000292486Add
BLAST

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00008355.

Structurei

3D structure databases

ProteinModelPortaliA1CEK6.
SMRiA1CEK6. Positions 220-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 145130VHSPROSITE-ProRule annotationAdd
BLAST
Repeati162 – 18120UIMAdd
BLAST
Domaini215 – 27460SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi372 – 575204Pro-richAdd
BLAST
Compositional biasi441 – 50868Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG309509.
HOGENOMiHOG000048362.
KOiK04705.
OMAiGEYQAYN.
OrthoDBiEOG75MW70.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CEK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM
60 70 80 90 100
IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR
110 120 130 140 150
NTHQQVKSKI LERMHDWTRM FSSNPDFGIM EQAYMKLKTQ NPNLQPPSKP
160 170 180 190 200
VKKEITQADR QKEEEELQMA LALSIREKSD AGPAPQAESS APASAPVSQT
210 220 230 240 250
QAAAPQAVPS GTSAATVSRV RALFDFQPSE PGELQFRKGD IIAVLESVYK
260 270 280 290 300
DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEADV FGQIKNVEKL
310 320 330 340 350
LTLLSTRSSE LNVQDNEEIT ALYHSTLAIR PKLIELIGKY SQKKDEFTQL
360 370 380 390 400
NEKFIKARRD YESLLEASMS HPPQPQYARP GQPPYGYPAP TGPHGYPQGA
410 420 430 440 450
PQPDPQRYFS PRPQDQTHMY PPTSQSPDPR GRTPPAGPTM QQQQQQPPAE
460 470 480 490 500
SFQPMHHRPE STYDNPQELG TSVYDSPVEY PPANQRFQYP PGASAPPGVH
510 520 530 540 550
QQLQQQQQEY SPSNYSPEDT TNPPTANFPP QPQQSQLPYP TGPAGHQAPP
560 570 580 590
SHQPPPVPGG ASKPSPYPSL TPGAPSAGEY QAYNPSQASA SSNPASFYR
Length:599
Mass (Da):66,319
Last modified:January 23, 2007 - v1
Checksum:i587E0488CE3587C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11305.1.
RefSeqiXP_001272731.1. XM_001272730.1.

Genome annotation databases

EnsemblFungiiCADACLAT00008565; CADACLAP00008355; CADACLAG00008565.
GeneIDi4705069.
KEGGiact:ACLA_089980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11305.1 .
RefSeqi XP_001272731.1. XM_001272730.1.

3D structure databases

ProteinModelPortali A1CEK6.
SMRi A1CEK6. Positions 220-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00008355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00008565 ; CADACLAP00008355 ; CADACLAG00008565 .
GeneIDi 4705069.
KEGGi act:ACLA_089980.

Phylogenomic databases

eggNOGi NOG309509.
HOGENOMi HOG000048362.
KOi K04705.
OMAi GEYQAYN.
OrthoDBi EOG75MW70.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
InterProi IPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view ]
Pfami PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTi SM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiHSE1_ASPCL
AccessioniPrimary (citable) accession number: A1CEK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3