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A1CEK6 (HSE1_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene names
Name:hse1
ORF Names:ACLA_089980
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) By similarity.

Subunit structure

Component of the ESCRT-0 complex composed of HSE1 and VPS27 By similarity.

Subcellular location

Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the STAM family.

Contains 1 SH3 domain.

Contains 1 UIM (ubiquitin-interacting motif) repeat.

Contains 1 VHS domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentEndosome
Membrane
   DomainSH3 domain
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

late endosome to vacuole transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentESCRT-0 complex

Inferred from electronic annotation. Source: InterPro

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Class E vacuolar protein-sorting machinery protein hse1
PRO_0000292486

Regions

Domain16 – 145130VHS
Repeat162 – 18120UIM
Domain215 – 27460SH3
Compositional bias372 – 575204Pro-rich
Compositional bias441 – 50868Gln-rich

Sequences

Sequence LengthMass (Da)Tools
A1CEK6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 587E0488CE3587C8

FASTA59966,319
        10         20         30         40         50         60 
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM IKRLAHRNAN 

        70         80         90        100        110        120 
VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR NTHQQVKSKI LERMHDWTRM 

       130        140        150        160        170        180 
FSSNPDFGIM EQAYMKLKTQ NPNLQPPSKP VKKEITQADR QKEEEELQMA LALSIREKSD 

       190        200        210        220        230        240 
AGPAPQAESS APASAPVSQT QAAAPQAVPS GTSAATVSRV RALFDFQPSE PGELQFRKGD 

       250        260        270        280        290        300 
IIAVLESVYK DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEADV FGQIKNVEKL 

       310        320        330        340        350        360 
LTLLSTRSSE LNVQDNEEIT ALYHSTLAIR PKLIELIGKY SQKKDEFTQL NEKFIKARRD 

       370        380        390        400        410        420 
YESLLEASMS HPPQPQYARP GQPPYGYPAP TGPHGYPQGA PQPDPQRYFS PRPQDQTHMY 

       430        440        450        460        470        480 
PPTSQSPDPR GRTPPAGPTM QQQQQQPPAE SFQPMHHRPE STYDNPQELG TSVYDSPVEY 

       490        500        510        520        530        540 
PPANQRFQYP PGASAPPGVH QQLQQQQQEY SPSNYSPEDT TNPPTANFPP QPQQSQLPYP 

       550        560        570        580        590 
TGPAGHQAPP SHQPPPVPGG ASKPSPYPSL TPGAPSAGEY QAYNPSQASA SSNPASFYR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027052 Genomic DNA. Translation: EAW11305.1.
RefSeqXP_001272731.1. XM_001272730.1.

3D structure databases

ProteinModelPortalA1CEK6.
SMRA1CEK6. Positions 220-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00008355.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00008565; CADACLAP00008355; CADACLAG00008565.
GeneID4705069.
KEGGact:ACLA_089980.

Phylogenomic databases

eggNOGNOG309509.
HOGENOMHOG000048362.
KOK04705.
OMAGEYQAYN.
OrthoDBEOG75MW70.

Family and domain databases

Gene3D1.25.40.90. 1 hit.
InterProIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR027423. Sorting_HSE1.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PANTHERPTHR13856:SF44. PTHR13856:SF44. 1 hit.
PfamPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHSE1_ASPCL
AccessionPrimary (citable) accession number: A1CEK6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families