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A1CEK6

- HSE1_ASPCL

UniProt

A1CEK6 - HSE1_ASPCL

Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class E vacuolar protein-sorting machinery protein hse1
    Gene namesi
    Name:hse1
    ORF Names:ACLA_089980
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Class E vacuolar protein-sorting machinery protein hse1PRO_0000292486Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00008355.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CEK6.
    SMRiA1CEK6. Positions 220-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 145130VHSPROSITE-ProRule annotationAdd
    BLAST
    Repeati162 – 18120UIMAdd
    BLAST
    Domaini215 – 27460SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi372 – 575204Pro-richAdd
    BLAST
    Compositional biasi441 – 50868Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the STAM family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG309509.
    HOGENOMiHOG000048362.
    KOiK04705.
    OMAiGEYQAYN.
    OrthoDBiEOG75MW70.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view]
    PfamiPF00018. SH3_1. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTiSM00326. SH3. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1CEK6-1 [UniParc]FASTAAdd to Basket

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    MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM    50
    IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR 100
    NTHQQVKSKI LERMHDWTRM FSSNPDFGIM EQAYMKLKTQ NPNLQPPSKP 150
    VKKEITQADR QKEEEELQMA LALSIREKSD AGPAPQAESS APASAPVSQT 200
    QAAAPQAVPS GTSAATVSRV RALFDFQPSE PGELQFRKGD IIAVLESVYK 250
    DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEADV FGQIKNVEKL 300
    LTLLSTRSSE LNVQDNEEIT ALYHSTLAIR PKLIELIGKY SQKKDEFTQL 350
    NEKFIKARRD YESLLEASMS HPPQPQYARP GQPPYGYPAP TGPHGYPQGA 400
    PQPDPQRYFS PRPQDQTHMY PPTSQSPDPR GRTPPAGPTM QQQQQQPPAE 450
    SFQPMHHRPE STYDNPQELG TSVYDSPVEY PPANQRFQYP PGASAPPGVH 500
    QQLQQQQQEY SPSNYSPEDT TNPPTANFPP QPQQSQLPYP TGPAGHQAPP 550
    SHQPPPVPGG ASKPSPYPSL TPGAPSAGEY QAYNPSQASA SSNPASFYR 599
    Length:599
    Mass (Da):66,319
    Last modified:January 23, 2007 - v1
    Checksum:i587E0488CE3587C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027052 Genomic DNA. Translation: EAW11305.1.
    RefSeqiXP_001272731.1. XM_001272730.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00008565; CADACLAP00008355; CADACLAG00008565.
    GeneIDi4705069.
    KEGGiact:ACLA_089980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027052 Genomic DNA. Translation: EAW11305.1 .
    RefSeqi XP_001272731.1. XM_001272730.1.

    3D structure databases

    ProteinModelPortali A1CEK6.
    SMRi A1CEK6. Positions 220-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00008355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00008565 ; CADACLAP00008355 ; CADACLAG00008565 .
    GeneIDi 4705069.
    KEGGi act:ACLA_089980.

    Phylogenomic databases

    eggNOGi NOG309509.
    HOGENOMi HOG000048362.
    KOi K04705.
    OMAi GEYQAYN.
    OrthoDBi EOG75MW70.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view ]
    Pfami PF00018. SH3_1. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTi SM00326. SH3. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiHSE1_ASPCL
    AccessioniPrimary (citable) accession number: A1CEK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3