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A1CE97 (CBHA_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 1,4-beta-D-glucan cellobiohydrolase A

EC=3.2.1.91
Alternative name(s):
Beta-glucancellobiohydrolase A
Cellobiohydrolase D
Exocellobiohydrolase A
Exoglucanase A
Gene names
Name:cbhA
Synonyms:celD
ORF Names:ACLA_088870
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose By similarity.

Catalytic activity

Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the glycosyl hydrolase 7 (cellulase C) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncellulose 1,4-beta-cellobiosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 453436Probable 1,4-beta-D-glucan cellobiohydrolase A
PRO_0000393538

Sites

Active site2261Nucleophile By similarity
Active site2311Proton donor By similarity

Amino acid modifications

Glycosylation2841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CE97 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 472F3E0D782C2396

FASTA45348,214
        10         20         30         40         50         60 
MYQRALLFSA LATAVSAQQV GTQKAEVHPA LTWQKCTAAG SCTDQKGSVV IDANWRWLHS 

        70         80         90        100        110        120 
TEDTTNCYTG NEWNAELCPD NEACAKNCAL DGADYSGTYG VTADGSSLKL NFVTSANVGS 

       130        140        150        160        170        180 
RLYLMEDDET YQMFNLLNNE FTFDVDVSNL PCGLNGALYF VSMDADGGLS KYPGNKAGAK 

       190        200        210        220        230        240 
YGTGYCDSQC PRDLKFINGE ANVEGWKPSD NDKNAGVGGY GSCCPEMDIW EANSISTAYT 

       250        260        270        280        290        300 
PHPCDGMEQT RCDGNDCGGT YSSTRYAGTC DPDGCDFNSF RMGNESFYGP GGLVDTKSPI 

       310        320        330        340        350        360 
TVVTQFVTAG GTDSGALKEI RRVYVQGGKV IGNSASNVAG VEGDSITSDF CTAQKKAFGD 

       370        380        390        400        410        420 
EDIFSKHGGL EGMGKALNKM ALIVSIWDDH ASSMMWLDST YPVDADASTP GVARGTCEHG 

       430        440        450 
LGDPETVESQ HPDASVTFSN IKFGPIGSTY KSV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027052 Genomic DNA. Translation: EAW11196.1.
RefSeqXP_001272622.1. XM_001272621.1.

3D structure databases

ProteinModelPortalA1CE97.
SMRA1CE97. Positions 18-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00008198.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00008408; CADACLAP00008198; CADACLAG00008408.
GeneID4704945.
KEGGact:ACLA_088870.

Phylogenomic databases

eggNOGNOG85664.
HOGENOMHOG000182210.
OMANWSKCTS.
OrthoDBEOG7ZGXCF.

Family and domain databases

Gene3D2.70.100.10. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSPR00734. GLHYDRLASE7.
SUPFAMSSF49899. SSF49899. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCBHA_ASPCL
AccessionPrimary (citable) accession number: A1CE97
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries