ID   RT106_ASPCL             Reviewed;         463 AA.
AC   A1CE78;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Histone chaperone rtt106;
GN   Name=rtt106; ORFNames=ACLA_088660;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Histones H3 and H4 chaperone involved in the nucleosome
CC       formation and heterochromatin silencing. Required for the deposition of
CC       H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role
CC       in the transcriptional regulation of the cell-cycle dependent histone
CC       genes by creating a repressive structure at the core histone gene
CC       promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histones H3 and H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RTT106 family. {ECO:0000305}.
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DR   EMBL; DS027052; EAW11177.1; -; Genomic_DNA.
DR   RefSeq; XP_001272603.1; XM_001272602.1.
DR   AlphaFoldDB; A1CE78; -.
DR   SMR; A1CE78; -.
DR   STRING; 344612.A1CE78; -.
DR   EnsemblFungi; EAW11177; EAW11177; ACLA_088660.
DR   GeneID; 4705009; -.
DR   KEGG; act:ACLA_088660; -.
DR   VEuPathDB; FungiDB:ACLA_088660; -.
DR   eggNOG; ENOG502R9PE; Eukaryota.
DR   HOGENOM; CLU_033828_0_0_1; -.
DR   OMA; AMPEAHR; -.
DR   OrthoDB; 1359279at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.29.120; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013719; RTT106/SPT16-like_middle_dom.
DR   PANTHER; PTHR45849; FACT COMPLEX SUBUNIT SSRP1; 1.
DR   PANTHER; PTHR45849:SF3; HISTONE CHAPERONE RTT106; 1.
DR   Pfam; PF08512; Rttp106-like_middle; 1.
DR   SMART; SM01287; Rtt106; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..463
FT                   /note="Histone chaperone rtt106"
FT                   /id="PRO_0000320482"
FT   REGION          60..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          368..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..463
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  51196 MW;  20BCB4CEA2F3103C CRC64;
     MVFATINRSA TKTVPATIPA IEEAFAAEPS LKKRVYDAIE NTPQYVPLFE DIARYTSSLL
     ARPTNPPAQP AEASEGPAAK KRKLQNGTAA ANAQSPADVK AETSLQFYMQ DVSFAMPQRK
     KLTLEITAGR GFLRARNQTS KEVEFGVPMD RIRHVLCLPV PEKAQRQFNF CVIPQYSDGI
     NPPTEGEEVF ESMVWTISDG PAKAAFSGTG QQIGNKEGET AESLVRRILN ENLSHIKVVR
     PDEREFVSAM PEAHRKGEKA YHVKAFRGSK EGYLFFLSTG VFFGFKKPLV FFAFENIVSI
     SYTSVLQRTF NLNIAVRSHN GAEDETQEFE LSMIDQADYA GIDAYIKKHG LQDASLAEAR
     RAKRYNINGA KAEEDTTNNA EGAAAEEESE LQKAQRELED QEDEDEEDYD PGSDGESEGS
     GSSSEDDDED DEDDEEDDDN EGDEDLVAAE LGSEAEDVPQ DEL
//