A1CE78 (RT106_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone chaperone rtt106

Gene names

Name:	rtt106
ORF Names:	ACLA_088660

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus clavatus

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter By similarity.
Subunit structure	Interacts with histones H3 and H4 By similarity.
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the RTT106 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Ligand	DNA-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Histone chaperone rtt106		PRO_0000320482

Sequences

	Sequence		Length	Mass (Da)
	A1CE78 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 20BCB4CEA2F3103C	FASTA	463	51,196
	10 20 30 40 50 60 MVFATINRSA TKTVPATIPA IEEAFAAEPS LKKRVYDAIE NTPQYVPLFE DIARYTSSLL 70 80 90 100 110 120 ARPTNPPAQP AEASEGPAAK KRKLQNGTAA ANAQSPADVK AETSLQFYMQ DVSFAMPQRK 130 140 150 160 170 180 KLTLEITAGR GFLRARNQTS KEVEFGVPMD RIRHVLCLPV PEKAQRQFNF CVIPQYSDGI 190 200 210 220 230 240 NPPTEGEEVF ESMVWTISDG PAKAAFSGTG QQIGNKEGET AESLVRRILN ENLSHIKVVR 250 260 270 280 290 300 PDEREFVSAM PEAHRKGEKA YHVKAFRGSK EGYLFFLSTG VFFGFKKPLV FFAFENIVSI 310 320 330 340 350 360 SYTSVLQRTF NLNIAVRSHN GAEDETQEFE LSMIDQADYA GIDAYIKKHG LQDASLAEAR 370 380 390 400 410 420 RAKRYNINGA KAEEDTTNNA EGAAAEEESE LQKAQRELED QEDEDEEDYD PGSDGESEGS 430 440 450 460 GSSSEDDDED DEDDEEDDDN EGDEDLVAAE LGSEAEDVPQ DEL

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027052 Genomic DNA. Translation: EAW11177.1.
RefSeq	XP_001272603.1. XM_001272602.1.
3D structure databases
ProteinModelPortal	A1CE78.
ModBase	Search...
Protein-protein interaction databases
STRING	5057.CADACLAP00008708.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00008918; CADACLAP00008708; CADACLAG00008918.
GeneID	4705009.
KEGG	act:ACLA_088660.
Phylogenomic databases
eggNOG	NOG78439.
HOGENOM	HOG000048523.
OrthoDB	EOG4HTD28.
Family and domain databases
InterPro	IPR013719. DUF1747. [Graphical view]
Pfam	PF08512. Rtt106. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RT106_ASPCL

Accession

Primary (citable) accession number: A1CE78

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program