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Protein

Histone chaperone rtt106

Gene

rtt106

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone chaperone rtt106
Gene namesi
Name:rtt106
ORF Names:ACLA_088660
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Histone chaperone rtt106PRO_0000320482Add
BLAST

Interactioni

Subunit structurei

Interacts with histones H3 and H4.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00008708.

Structurei

3D structure databases

ProteinModelPortaliA1CE78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RTT106 family.Curated

Phylogenomic databases

eggNOGiNOG78439.
HOGENOMiHOG000048523.
OMAiHWALTTS.
OrthoDBiEOG7TBCC0.

Family and domain databases

InterProiIPR013719. DUF1747.
[Graphical view]
PfamiPF08512. Rtt106. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CE78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFATINRSA TKTVPATIPA IEEAFAAEPS LKKRVYDAIE NTPQYVPLFE
60 70 80 90 100
DIARYTSSLL ARPTNPPAQP AEASEGPAAK KRKLQNGTAA ANAQSPADVK
110 120 130 140 150
AETSLQFYMQ DVSFAMPQRK KLTLEITAGR GFLRARNQTS KEVEFGVPMD
160 170 180 190 200
RIRHVLCLPV PEKAQRQFNF CVIPQYSDGI NPPTEGEEVF ESMVWTISDG
210 220 230 240 250
PAKAAFSGTG QQIGNKEGET AESLVRRILN ENLSHIKVVR PDEREFVSAM
260 270 280 290 300
PEAHRKGEKA YHVKAFRGSK EGYLFFLSTG VFFGFKKPLV FFAFENIVSI
310 320 330 340 350
SYTSVLQRTF NLNIAVRSHN GAEDETQEFE LSMIDQADYA GIDAYIKKHG
360 370 380 390 400
LQDASLAEAR RAKRYNINGA KAEEDTTNNA EGAAAEEESE LQKAQRELED
410 420 430 440 450
QEDEDEEDYD PGSDGESEGS GSSSEDDDED DEDDEEDDDN EGDEDLVAAE
460
LGSEAEDVPQ DEL
Length:463
Mass (Da):51,196
Last modified:January 23, 2007 - v1
Checksum:i20BCB4CEA2F3103C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11177.1.
RefSeqiXP_001272603.1. XM_001272602.1.

Genome annotation databases

EnsemblFungiiCADACLAT00008918; CADACLAP00008708; CADACLAG00008918.
GeneIDi4705009.
KEGGiact:ACLA_088660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11177.1.
RefSeqiXP_001272603.1. XM_001272602.1.

3D structure databases

ProteinModelPortaliA1CE78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00008708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00008918; CADACLAP00008708; CADACLAG00008918.
GeneIDi4705009.
KEGGiact:ACLA_088660.

Phylogenomic databases

eggNOGiNOG78439.
HOGENOMiHOG000048523.
OMAiHWALTTS.
OrthoDBiEOG7TBCC0.

Family and domain databases

InterProiIPR013719. DUF1747.
[Graphical view]
PfamiPF08512. Rtt106. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiRT106_ASPCL
AccessioniPrimary (citable) accession number: A1CE78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.