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A1CE56

- BGALC_ASPCL

UniProt

A1CE56 - BGALC_ASPCL

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821SubstrateBy similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Binding sitei128 – 1281Substrate; via amide nitrogenBy similarity
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei187 – 1871SubstrateBy similarity
    Active sitei188 – 1881Proton donorSequence Analysis
    Binding sitei251 – 2511SubstrateBy similarity
    Active sitei287 – 2871NucleophileSequence Analysis
    Binding sitei353 – 3531SubstrateBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-galactosidase C (EC:3.2.1.23)
    Alternative name(s):
    Lactase C
    Gene namesi
    Name:lacC
    ORF Names:ACLA_088440
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 985962Probable beta-galactosidase CPRO_0000395234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi257 ↔ 304By similarity
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi715 – 7151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi759 – 7591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00008328.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CE56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    HOGENOMiHOG000181922.
    OMAiSGEFHYQ.
    OrthoDBiEOG7ZGXBD.

    Family and domain databases

    Gene3Di2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PRINTSiPR00742. GLHYDRLASE35.
    SMARTiSM01029. BetaGal_dom2. 1 hit.
    [Graphical view]
    SUPFAMiSSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CE56-1 [UniParc]FASTAAdd to Basket

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    MRILSLLFLL LLGFLAGNRV VSATDHGKTT DVTWDRYSLS VKGERLFVFS    50
    GEFHYQRLPV PEMWLDVFQK LRANGFNAIS VYFFWGYHSA SEGEFDFETG 100
    AHNIQRLFDY AKEAGIYVIA RAGPYCNAET TAGGYALWAA NGQMGNERTS 150
    DDAYYAKWRP WILEVGKIIA ANQITNGGPV ILNQHENELQ ETSYEADNTL 200
    VVYMKQIARV FQEAGIVVPS SHNEKGMRAV SWSTDHHDVG GAVNIYGLDS 250
    YPGGLSCTNP SSGFNLVRTY YQWFQNSSYT QPEYLPEFEG GWFQPWGGHD 300
    YDTCATELSP EFADVYYKNN IGSRVTLQNI YMVFGGTNWG HSAAPVVYTS 350
    YDYSAPLRET REIRDKLKQT KLIGLFTRVS SDLLKTHMEG NGTGYTSDSS 400
    IYTWALHNPD TNAGFYVLAH KTSSSRSVTE FSLNVTTSAG AISIPDIQLD 450
    GRQSKIIVTD YQFGKSSALL YSSAEVLTYA NLDVDVLVLY LNVGQKGLFV 500
    FKDERSKLSF QTYGNTNVTA SVSSHGTQYI YTQAEGVTAV KFSNGVLAYL 550
    LDKESAWNFF APPTTSNPQV APDEHILVQG PYLVRGVTIN HDTVEIIGDN 600
    ANTTSLEVYA GNLRVKVVKW NGKAIKSRRT AYGSLVGRAP GAEDARISPP 650
    SLDSWSAQDT LPDIQPDYDD SRWTVCNKTA SVNAVPLLSL PVLYSGDYGY 700
    HAGTKVYRGR FDGRNVTGAN VTVQNGVASG WAAWLNGQFV GGVAGAIDLA 750
    VTSAVLSFNS SLLHDRDNVL TVVTDYTGHD QNSVRPKGTQ NPRGILGATL 800
    IGGGKFTSWR IQGNAGGEKN IDPVRGPINE GGLYGERMGW HLPGYKAPRS 850
    AAKSSPLDGI SGAEGRFYTT TFTLKLDRDL DVPIGLQLGA PAGTQAVVQV 900
    FMNGYQFGHY LPHIGPQSLF PFPPGVINNR GENTLAISMW ALTDAGAKLD 950
    QVELVAYGKY RSGFDFNQDW GYLQPQWKDN RRQYA 985
    Length:985
    Mass (Da):108,394
    Last modified:January 23, 2007 - v1
    Checksum:i64345E996ADB15F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027052 Genomic DNA. Translation: EAW11155.1.
    RefSeqiXP_001272581.1. XM_001272580.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00008538; CADACLAP00008328; CADACLAG00008538.
    GeneIDi4704994.
    KEGGiact:ACLA_088440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027052 Genomic DNA. Translation: EAW11155.1 .
    RefSeqi XP_001272581.1. XM_001272580.1.

    3D structure databases

    ProteinModelPortali A1CE56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00008328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00008538 ; CADACLAP00008328 ; CADACLAG00008538 .
    GeneIDi 4704994.
    KEGGi act:ACLA_088440.

    Phylogenomic databases

    eggNOGi COG1874.
    HOGENOMi HOG000181922.
    OMAi SGEFHYQ.
    OrthoDBi EOG7ZGXBD.

    Family and domain databases

    Gene3Di 2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PRINTSi PR00742. GLHYDRLASE35.
    SMARTi SM01029. BetaGal_dom2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiBGALC_ASPCL
    AccessioniPrimary (citable) accession number: A1CE56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3