Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei128Substrate; via amide nitrogenBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei187SubstrateBy similarity1
Active sitei188Proton donorSequence analysis1
Binding sitei251SubstrateBy similarity1
Active sitei287NucleophileSequence analysis1
Binding sitei353SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:ACLA_088440
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_088440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000039523424 – 985Probable beta-galactosidase CAdd BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi257 ↔ 304By similarity
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi677N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi720N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi759N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA1CE56

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00008328

Structurei

3D structure databases

ProteinModelPortaliA1CE56
SMRiA1CE56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922
OMAiEFEGGWF
OrthoDBiEOG092C0SLI

Family and domain databases

Gene3Di2.102.20.10, 1 hit
2.60.120.260, 2 hits
2.60.390.10, 1 hit
InterProiView protein in InterPro
IPR018954 Betagal_dom2
IPR037110 Betagal_dom2_sf
IPR025972 BetaGal_dom3
IPR036833 BetaGal_dom3_sf
IPR025300 BetaGal_jelly_roll_dom
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF10435 BetaGal_dom2, 1 hit
PF13363 BetaGal_dom3, 1 hit
PF13364 BetaGal_dom4_5, 2 hits
PF01301 Glyco_hydro_35, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SMARTiView protein in SMART
SM01029 BetaGal_dom2, 1 hit
SUPFAMiSSF117100 SSF117100, 1 hit
SSF49785 SSF49785, 2 hits
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CE56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILSLLFLL LLGFLAGNRV VSATDHGKTT DVTWDRYSLS VKGERLFVFS
60 70 80 90 100
GEFHYQRLPV PEMWLDVFQK LRANGFNAIS VYFFWGYHSA SEGEFDFETG
110 120 130 140 150
AHNIQRLFDY AKEAGIYVIA RAGPYCNAET TAGGYALWAA NGQMGNERTS
160 170 180 190 200
DDAYYAKWRP WILEVGKIIA ANQITNGGPV ILNQHENELQ ETSYEADNTL
210 220 230 240 250
VVYMKQIARV FQEAGIVVPS SHNEKGMRAV SWSTDHHDVG GAVNIYGLDS
260 270 280 290 300
YPGGLSCTNP SSGFNLVRTY YQWFQNSSYT QPEYLPEFEG GWFQPWGGHD
310 320 330 340 350
YDTCATELSP EFADVYYKNN IGSRVTLQNI YMVFGGTNWG HSAAPVVYTS
360 370 380 390 400
YDYSAPLRET REIRDKLKQT KLIGLFTRVS SDLLKTHMEG NGTGYTSDSS
410 420 430 440 450
IYTWALHNPD TNAGFYVLAH KTSSSRSVTE FSLNVTTSAG AISIPDIQLD
460 470 480 490 500
GRQSKIIVTD YQFGKSSALL YSSAEVLTYA NLDVDVLVLY LNVGQKGLFV
510 520 530 540 550
FKDERSKLSF QTYGNTNVTA SVSSHGTQYI YTQAEGVTAV KFSNGVLAYL
560 570 580 590 600
LDKESAWNFF APPTTSNPQV APDEHILVQG PYLVRGVTIN HDTVEIIGDN
610 620 630 640 650
ANTTSLEVYA GNLRVKVVKW NGKAIKSRRT AYGSLVGRAP GAEDARISPP
660 670 680 690 700
SLDSWSAQDT LPDIQPDYDD SRWTVCNKTA SVNAVPLLSL PVLYSGDYGY
710 720 730 740 750
HAGTKVYRGR FDGRNVTGAN VTVQNGVASG WAAWLNGQFV GGVAGAIDLA
760 770 780 790 800
VTSAVLSFNS SLLHDRDNVL TVVTDYTGHD QNSVRPKGTQ NPRGILGATL
810 820 830 840 850
IGGGKFTSWR IQGNAGGEKN IDPVRGPINE GGLYGERMGW HLPGYKAPRS
860 870 880 890 900
AAKSSPLDGI SGAEGRFYTT TFTLKLDRDL DVPIGLQLGA PAGTQAVVQV
910 920 930 940 950
FMNGYQFGHY LPHIGPQSLF PFPPGVINNR GENTLAISMW ALTDAGAKLD
960 970 980
QVELVAYGKY RSGFDFNQDW GYLQPQWKDN RRQYA
Length:985
Mass (Da):108,394
Last modified:January 23, 2007 - v1
Checksum:i64345E996ADB15F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA Translation: EAW11155.1
RefSeqiXP_001272581.1, XM_001272580.1

Genome annotation databases

EnsemblFungiiCADACLAT00008538; CADACLAP00008328; CADACLAG00008538
GeneIDi4704994
KEGGiact:ACLA_088440

Similar proteinsi

Entry informationi

Entry nameiBGALC_ASPCL
AccessioniPrimary (citable) accession number: A1CE56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health