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A1CE56

- BGALC_ASPCL

UniProt

A1CE56 - BGALC_ASPCL

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Protein

Probable beta-galactosidase C

Gene
lacC, ACLA_088440
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei128 – 1281Substrate; via amide nitrogen By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Active sitei188 – 1881Proton donor Reviewed prediction
Binding sitei251 – 2511Substrate By similarity
Active sitei287 – 2871Nucleophile Reviewed prediction
Binding sitei353 – 3531Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:ACLA_088440
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 985962Probable beta-galactosidase CPRO_0000395234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi257 ↔ 304 By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi602 – 6021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi677 – 6771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi715 – 7151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi720 – 7201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi759 – 7591N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00008328.

Structurei

3D structure databases

ProteinModelPortaliA1CE56.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OMAiSGEFHYQ.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CE56-1 [UniParc]FASTAAdd to Basket

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MRILSLLFLL LLGFLAGNRV VSATDHGKTT DVTWDRYSLS VKGERLFVFS    50
GEFHYQRLPV PEMWLDVFQK LRANGFNAIS VYFFWGYHSA SEGEFDFETG 100
AHNIQRLFDY AKEAGIYVIA RAGPYCNAET TAGGYALWAA NGQMGNERTS 150
DDAYYAKWRP WILEVGKIIA ANQITNGGPV ILNQHENELQ ETSYEADNTL 200
VVYMKQIARV FQEAGIVVPS SHNEKGMRAV SWSTDHHDVG GAVNIYGLDS 250
YPGGLSCTNP SSGFNLVRTY YQWFQNSSYT QPEYLPEFEG GWFQPWGGHD 300
YDTCATELSP EFADVYYKNN IGSRVTLQNI YMVFGGTNWG HSAAPVVYTS 350
YDYSAPLRET REIRDKLKQT KLIGLFTRVS SDLLKTHMEG NGTGYTSDSS 400
IYTWALHNPD TNAGFYVLAH KTSSSRSVTE FSLNVTTSAG AISIPDIQLD 450
GRQSKIIVTD YQFGKSSALL YSSAEVLTYA NLDVDVLVLY LNVGQKGLFV 500
FKDERSKLSF QTYGNTNVTA SVSSHGTQYI YTQAEGVTAV KFSNGVLAYL 550
LDKESAWNFF APPTTSNPQV APDEHILVQG PYLVRGVTIN HDTVEIIGDN 600
ANTTSLEVYA GNLRVKVVKW NGKAIKSRRT AYGSLVGRAP GAEDARISPP 650
SLDSWSAQDT LPDIQPDYDD SRWTVCNKTA SVNAVPLLSL PVLYSGDYGY 700
HAGTKVYRGR FDGRNVTGAN VTVQNGVASG WAAWLNGQFV GGVAGAIDLA 750
VTSAVLSFNS SLLHDRDNVL TVVTDYTGHD QNSVRPKGTQ NPRGILGATL 800
IGGGKFTSWR IQGNAGGEKN IDPVRGPINE GGLYGERMGW HLPGYKAPRS 850
AAKSSPLDGI SGAEGRFYTT TFTLKLDRDL DVPIGLQLGA PAGTQAVVQV 900
FMNGYQFGHY LPHIGPQSLF PFPPGVINNR GENTLAISMW ALTDAGAKLD 950
QVELVAYGKY RSGFDFNQDW GYLQPQWKDN RRQYA 985
Length:985
Mass (Da):108,394
Last modified:January 23, 2007 - v1
Checksum:i64345E996ADB15F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027052 Genomic DNA. Translation: EAW11155.1.
RefSeqiXP_001272581.1. XM_001272580.1.

Genome annotation databases

EnsemblFungiiCADACLAT00008538; CADACLAP00008328; CADACLAG00008538.
GeneIDi4704994.
KEGGiact:ACLA_088440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027052 Genomic DNA. Translation: EAW11155.1 .
RefSeqi XP_001272581.1. XM_001272580.1.

3D structure databases

ProteinModelPortali A1CE56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00008328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00008538 ; CADACLAP00008328 ; CADACLAG00008538 .
GeneIDi 4704994.
KEGGi act:ACLA_088440.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OMAi SGEFHYQ.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBGALC_ASPCL
AccessioniPrimary (citable) accession number: A1CE56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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