Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1CE56

- BGALC_ASPCL

UniProt

A1CE56 - BGALC_ASPCL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821SubstrateBy similarity
Binding sitei127 – 1271SubstrateBy similarity
Binding sitei128 – 1281Substrate; via amide nitrogenBy similarity
Binding sitei129 – 1291SubstrateBy similarity
Binding sitei187 – 1871SubstrateBy similarity
Active sitei188 – 1881Proton donorSequence Analysis
Binding sitei251 – 2511SubstrateBy similarity
Active sitei287 – 2871NucleophileSequence Analysis
Binding sitei353 – 3531SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:ACLA_088440
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 985962Probable beta-galactosidase CPRO_0000395234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi257 ↔ 304By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi715 – 7151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi759 – 7591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00008328.

Structurei

3D structure databases

ProteinModelPortaliA1CE56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OMAiSGEFHYQ.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CE56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRILSLLFLL LLGFLAGNRV VSATDHGKTT DVTWDRYSLS VKGERLFVFS
60 70 80 90 100
GEFHYQRLPV PEMWLDVFQK LRANGFNAIS VYFFWGYHSA SEGEFDFETG
110 120 130 140 150
AHNIQRLFDY AKEAGIYVIA RAGPYCNAET TAGGYALWAA NGQMGNERTS
160 170 180 190 200
DDAYYAKWRP WILEVGKIIA ANQITNGGPV ILNQHENELQ ETSYEADNTL
210 220 230 240 250
VVYMKQIARV FQEAGIVVPS SHNEKGMRAV SWSTDHHDVG GAVNIYGLDS
260 270 280 290 300
YPGGLSCTNP SSGFNLVRTY YQWFQNSSYT QPEYLPEFEG GWFQPWGGHD
310 320 330 340 350
YDTCATELSP EFADVYYKNN IGSRVTLQNI YMVFGGTNWG HSAAPVVYTS
360 370 380 390 400
YDYSAPLRET REIRDKLKQT KLIGLFTRVS SDLLKTHMEG NGTGYTSDSS
410 420 430 440 450
IYTWALHNPD TNAGFYVLAH KTSSSRSVTE FSLNVTTSAG AISIPDIQLD
460 470 480 490 500
GRQSKIIVTD YQFGKSSALL YSSAEVLTYA NLDVDVLVLY LNVGQKGLFV
510 520 530 540 550
FKDERSKLSF QTYGNTNVTA SVSSHGTQYI YTQAEGVTAV KFSNGVLAYL
560 570 580 590 600
LDKESAWNFF APPTTSNPQV APDEHILVQG PYLVRGVTIN HDTVEIIGDN
610 620 630 640 650
ANTTSLEVYA GNLRVKVVKW NGKAIKSRRT AYGSLVGRAP GAEDARISPP
660 670 680 690 700
SLDSWSAQDT LPDIQPDYDD SRWTVCNKTA SVNAVPLLSL PVLYSGDYGY
710 720 730 740 750
HAGTKVYRGR FDGRNVTGAN VTVQNGVASG WAAWLNGQFV GGVAGAIDLA
760 770 780 790 800
VTSAVLSFNS SLLHDRDNVL TVVTDYTGHD QNSVRPKGTQ NPRGILGATL
810 820 830 840 850
IGGGKFTSWR IQGNAGGEKN IDPVRGPINE GGLYGERMGW HLPGYKAPRS
860 870 880 890 900
AAKSSPLDGI SGAEGRFYTT TFTLKLDRDL DVPIGLQLGA PAGTQAVVQV
910 920 930 940 950
FMNGYQFGHY LPHIGPQSLF PFPPGVINNR GENTLAISMW ALTDAGAKLD
960 970 980
QVELVAYGKY RSGFDFNQDW GYLQPQWKDN RRQYA
Length:985
Mass (Da):108,394
Last modified:January 23, 2007 - v1
Checksum:i64345E996ADB15F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11155.1.
RefSeqiXP_001272581.1. XM_001272580.1.

Genome annotation databases

EnsemblFungiiCADACLAT00008538; CADACLAP00008328; CADACLAG00008538.
GeneIDi4704994.
KEGGiact:ACLA_088440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11155.1 .
RefSeqi XP_001272581.1. XM_001272580.1.

3D structure databases

ProteinModelPortali A1CE56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00008328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00008538 ; CADACLAP00008328 ; CADACLAG00008538 .
GeneIDi 4704994.
KEGGi act:ACLA_088440.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OMAi SGEFHYQ.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBGALC_ASPCL
AccessioniPrimary (citable) accession number: A1CE56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3