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A1CE22

- A1CE22_ASPCL

UniProt

A1CE22 - A1CE22_ASPCL

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

ACLA_088100

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. nucleic acid binding Source: InterPro
    3. nucleotide binding Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    ORF Names:ACLA_088100Imported
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00008186.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CE22.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000181654.
    KOiK11422.
    OMAiDKTGYYI.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1CE22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRTSAGYAD FFPTAPSVLQ QRRIKAPRDH SLIKDRPGSE PKDGQLPSPE     50
    NTIANISTNS STLEFPITTI HTGQEKTQSR ETGRINLDTT STGSSILSST 100
    LAQSSLAQLK ELQIDTLTPL TNAGSSPPQR SSPCQSKSAG GIAEYNKPSN 150
    FVTEEAKLVV TPLHTPPTPQ SQTPRGGDIK GSKLIYDPDI DKRSSKEKRR 200
    KPQYVDFVVS DPKSCPADPR LSISNYTRGA GCKQKTKYRP APYRLKQWPY 250
    DASTTLGPGP PIQIVVTGFD PLTPIAPISA LFSSFGEVSE INNRTDPITG 300
    RFLGVCSVRY KDSNSFRGAE SIPAATAARR AFLECKKEQR IGTRRIRVEL 350
    DRDGAVSDKI VAKTIESQRM GHRKNTVLEE AKLEPRLKRS EPPPTAPKGP 400
    SRSSTRPGLA IPEGPRASFV KPAVPSLVEE TPILSQIKRE PYIFIAHCYV 450
    PVLSTTVPHL KKRLKLFDWK DIRCDKTGYY IIFENSRRGE EETQRCFKVC 500
    HMKPLFTYIM NMESQPYGNP NYERSPSPER LQAERREKSE RERVKREADL 550
    DIEEEKQQRA INMDPCREVL ALIVRDLKDK LLEDVKSRIA APALYDYLDP 600
    ERHALKRQQL GLRDPEGIKK PAFRIDVEAS LGPGQSRSVL SDGRHTFSPY 650
    GLNILALPRI RKSHRLNSAD AAFVDERRKQ PMRKKEVRPL YHRLQQLHSV 700
    DDSDDESRTP FTVDPDEQDS RPPSRMSSRS SDSDDGESAP EALDGFVSAQ 750
    AKHGMDVLQT PVTEHTIDQY PHKDTPDSSL TCKRKRPAED VEARKRLKED 800
    ECEHLNRNLP AETALDLSTL RVDHDVLGSV DHIDDYQKHS IQVSDKTIQA 850
    HEDHEQTSDG TPDIDSIIQN AGIEVKLQSP DEHDNAERHD GMRTEVEWGV 900
    SNNEPRSTVD DDETIVMDLD GWQALVKDEE DLCFLRDVLS GLPWSKVDNL 950
    SAWAWRQKEI KALSRPNETG PVHEEIKISG YYVCNFTGAA RTEGRKRILE 1000
    SEKSKYLPHR IRVQKAREER EAKARSDPHA TAAEAARITA AKTISKSTSR 1050
    STRVNNRRLV ADINAQKQAL PMQSGDGDAL RFNQLKKRKK PVRFARSAIH 1100
    NWGLYAEENI SANDMIIEYV GEKVRQQVAD MRERQYLKSG IGSSYLFRID 1150
    ENTVIDATKR GGIARFINHS CTPNCTAKII KVDGSKRIVI YALRDIERDE 1200
    ELTYDYKFER EWDSDDRIPC LCGSTGCKGF LN 1232
    Length:1,232
    Mass (Da):138,805
    Last modified:January 23, 2007 - v1
    Checksum:i73A6994363B9F738
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027052 Genomic DNA. Translation: EAW11121.1.
    RefSeqiXP_001272547.1. XM_001272546.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00008396; CADACLAP00008186; CADACLAG00008396.
    GeneIDi4704868.
    KEGGiact:ACLA_088100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027052 Genomic DNA. Translation: EAW11121.1 .
    RefSeqi XP_001272547.1. XM_001272546.1.

    3D structure databases

    ProteinModelPortali A1CE22.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00008186.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00008396 ; CADACLAP00008186 ; CADACLAG00008396 .
    GeneIDi 4704868.
    KEGGi act:ACLA_088100.

    Phylogenomic databases

    HOGENOMi HOG000181654.
    KOi K11422.
    OMAi DKTGYYI.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1Imported.

    Entry informationi

    Entry nameiA1CE22_ASPCL
    AccessioniPrimary (citable) accession number: A1CE22
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3