ACLA_088100

Functionⁱ

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityⁱ

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functionⁱ

histone-lysine N-methyltransferase activity Source: UniProtKB-UniRule
nucleic acid binding Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase
Ligand	S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesⁱ	ORF Names:ACLA_088100Imported
Organismⁱ	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
Taxonomic identifierⁱ	344612 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus clavatus
Proteomesⁱ	UP000006701 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

EuPathDBⁱ	FungiDB:ACLA_088100.

EuPathDBⁱ

FungiDB:ACLA_088100.

Subcellular locationⁱ

Nucleus
UniRule annotation
Automatic assertion according to rulesⁱ
- PIRNR:PIRNR037104
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00574581

GO - Cellular componentⁱ

Set1C/COMPASS complex Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactionⁱ

Subunit structureⁱ

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	5057.CADACLAP00008186.

STRINGⁱ

5057.CADACLAP00008186.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1CE22.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1090 – 1207	SETInterPro annotationAdd BLAST		118
Domainⁱ	1216 – 1232	Post-SETInterPro annotationAdd BLAST		17

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000181654.
KEGG Orthology (KO) More...KOⁱ	K11422.
OMAⁱ	HMKKRLK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3T9B.

Family and domain databases

InterProⁱ	View protein in InterPro IPR024657. COMPASS_Set1_N-SET. IPR017111. Hist_H3-K4_MeTrfase_1_fun. IPR003616. Post-SET_dom. IPR000504. RRM_dom. IPR024636. SET_assoc. IPR001214. SET_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11764. N-SET. 1 hit. PF00856. SET. 1 hit. PF11767. SET_assoc. 1 hit.
PIRSFⁱ	PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 2 hits.
SMARTⁱ	View protein in SMART SM01291. N-SET. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit.
SUPFAMⁱ	SSF54928. SSF54928. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50868. POST_SET. 1 hit. PS51572. SAM_MT43_1. 1 hit. PS50280. SET. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A1CE22-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRTSAGYAD FFPTAPSVLQ QRRIKAPRDH SLIKDRPGSE PKDGQLPSPE 
        60         70         80         90        100
NTIANISTNS STLEFPITTI HTGQEKTQSR ETGRINLDTT STGSSILSST 
       110        120        130        140        150
LAQSSLAQLK ELQIDTLTPL TNAGSSPPQR SSPCQSKSAG GIAEYNKPSN 
       160        170        180        190        200
FVTEEAKLVV TPLHTPPTPQ SQTPRGGDIK GSKLIYDPDI DKRSSKEKRR 
       210        220        230        240        250
KPQYVDFVVS DPKSCPADPR LSISNYTRGA GCKQKTKYRP APYRLKQWPY 
       260        270        280        290        300
DASTTLGPGP PIQIVVTGFD PLTPIAPISA LFSSFGEVSE INNRTDPITG 
       310        320        330        340        350
RFLGVCSVRY KDSNSFRGAE SIPAATAARR AFLECKKEQR IGTRRIRVEL 
       360        370        380        390        400
DRDGAVSDKI VAKTIESQRM GHRKNTVLEE AKLEPRLKRS EPPPTAPKGP 
       410        420        430        440        450
SRSSTRPGLA IPEGPRASFV KPAVPSLVEE TPILSQIKRE PYIFIAHCYV 
       460        470        480        490        500
PVLSTTVPHL KKRLKLFDWK DIRCDKTGYY IIFENSRRGE EETQRCFKVC 
       510        520        530        540        550
HMKPLFTYIM NMESQPYGNP NYERSPSPER LQAERREKSE RERVKREADL 
       560        570        580        590        600
DIEEEKQQRA INMDPCREVL ALIVRDLKDK LLEDVKSRIA APALYDYLDP 
       610        620        630        640        650
ERHALKRQQL GLRDPEGIKK PAFRIDVEAS LGPGQSRSVL SDGRHTFSPY 
       660        670        680        690        700
GLNILALPRI RKSHRLNSAD AAFVDERRKQ PMRKKEVRPL YHRLQQLHSV 
       710        720        730        740        750
DDSDDESRTP FTVDPDEQDS RPPSRMSSRS SDSDDGESAP EALDGFVSAQ 
       760        770        780        790        800
AKHGMDVLQT PVTEHTIDQY PHKDTPDSSL TCKRKRPAED VEARKRLKED 
       810        820        830        840        850
ECEHLNRNLP AETALDLSTL RVDHDVLGSV DHIDDYQKHS IQVSDKTIQA 
       860        870        880        890        900
HEDHEQTSDG TPDIDSIIQN AGIEVKLQSP DEHDNAERHD GMRTEVEWGV 
       910        920        930        940        950
SNNEPRSTVD DDETIVMDLD GWQALVKDEE DLCFLRDVLS GLPWSKVDNL 
       960        970        980        990       1000
SAWAWRQKEI KALSRPNETG PVHEEIKISG YYVCNFTGAA RTEGRKRILE 
      1010       1020       1030       1040       1050
SEKSKYLPHR IRVQKAREER EAKARSDPHA TAAEAARITA AKTISKSTSR 
      1060       1070       1080       1090       1100
STRVNNRRLV ADINAQKQAL PMQSGDGDAL RFNQLKKRKK PVRFARSAIH 
      1110       1120       1130       1140       1150
NWGLYAEENI SANDMIIEYV GEKVRQQVAD MRERQYLKSG IGSSYLFRID 
      1160       1170       1180       1190       1200
ENTVIDATKR GGIARFINHS CTPNCTAKII KVDGSKRIVI YALRDIERDE 
      1210       1220       1230 
ELTYDYKFER EWDSDDRIPC LCGSTGCKGF LN

Length:1,232

Mass (Da):138,805

Last modified:January 23, 2007 - v1

Checksum:ⁱ73A6994363B9F738

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DS027052 Genomic DNA. Translation: EAW11121.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001272547.1. XM_001272546.1.

Genome annotation databases

EnsemblFungiⁱ	CADACLAT00008396; CADACLAP00008186; CADACLAG00008396.
GeneIDⁱ	4704868.
KEGGⁱ	act:ACLA_088100.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DS027052 Genomic DNA. Translation: EAW11121.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001272547.1. XM_001272546.1.

3D structure databases

ProteinModelPortalⁱ	A1CE22.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	5057.CADACLAP00008186.

STRINGⁱ

5057.CADACLAP00008186.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	CADACLAT00008396; CADACLAP00008186; CADACLAG00008396.
GeneIDⁱ	4704868.
KEGGⁱ	act:ACLA_088100.

Organism-specific databases

EuPathDBⁱ	FungiDB:ACLA_088100.

EuPathDBⁱ

FungiDB:ACLA_088100.

Phylogenomic databases

HOGENOMⁱ	HOG000181654.
KEGG Orthology (KO) More...KOⁱ	K11422.
OMAⁱ	HMKKRLK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3T9B.

Family and domain databases

InterProⁱ	View protein in InterPro IPR024657. COMPASS_Set1_N-SET. IPR017111. Hist_H3-K4_MeTrfase_1_fun. IPR003616. Post-SET_dom. IPR000504. RRM_dom. IPR024636. SET_assoc. IPR001214. SET_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11764. N-SET. 1 hit. PF00856. SET. 1 hit. PF11767. SET_assoc. 1 hit.
PIRSFⁱ	PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 2 hits.
SMARTⁱ	View protein in SMART SM01291. N-SET. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit.
SUPFAMⁱ	SSF54928. SSF54928. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50868. POST_SET. 1 hit. PS51572. SAM_MT43_1. 1 hit. PS50280. SET. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A1CE22_ASPCL
Accessionⁱ	A1CE22Primary (citable) accession number: A1CE22
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 23, 2007
	Last sequence update:	January 23, 2007
	Last modified:	July 5, 2017
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A1CE22 (A1CE22_ASPCL)

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Histone-lysine N-methyltransferase, H3 lysine-4 specific

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1CE22 (A1CE22_ASPCL)

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Histone-lysine N-methyltransferase, H3 lysine-4 specific

ACLA_088100

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ