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A1CE22

- A1CE22_ASPCL

UniProt

A1CE22 - A1CE22_ASPCL

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

ACLA_088100

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:ACLA_088100Imported
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi5057.CADACLAP00008186.

Structurei

3D structure databases

ProteinModelPortaliA1CE22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000181654.
KOiK11422.
OMAiDKTGYYI.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CE22-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRTSAGYAD FFPTAPSVLQ QRRIKAPRDH SLIKDRPGSE PKDGQLPSPE
60 70 80 90 100
NTIANISTNS STLEFPITTI HTGQEKTQSR ETGRINLDTT STGSSILSST
110 120 130 140 150
LAQSSLAQLK ELQIDTLTPL TNAGSSPPQR SSPCQSKSAG GIAEYNKPSN
160 170 180 190 200
FVTEEAKLVV TPLHTPPTPQ SQTPRGGDIK GSKLIYDPDI DKRSSKEKRR
210 220 230 240 250
KPQYVDFVVS DPKSCPADPR LSISNYTRGA GCKQKTKYRP APYRLKQWPY
260 270 280 290 300
DASTTLGPGP PIQIVVTGFD PLTPIAPISA LFSSFGEVSE INNRTDPITG
310 320 330 340 350
RFLGVCSVRY KDSNSFRGAE SIPAATAARR AFLECKKEQR IGTRRIRVEL
360 370 380 390 400
DRDGAVSDKI VAKTIESQRM GHRKNTVLEE AKLEPRLKRS EPPPTAPKGP
410 420 430 440 450
SRSSTRPGLA IPEGPRASFV KPAVPSLVEE TPILSQIKRE PYIFIAHCYV
460 470 480 490 500
PVLSTTVPHL KKRLKLFDWK DIRCDKTGYY IIFENSRRGE EETQRCFKVC
510 520 530 540 550
HMKPLFTYIM NMESQPYGNP NYERSPSPER LQAERREKSE RERVKREADL
560 570 580 590 600
DIEEEKQQRA INMDPCREVL ALIVRDLKDK LLEDVKSRIA APALYDYLDP
610 620 630 640 650
ERHALKRQQL GLRDPEGIKK PAFRIDVEAS LGPGQSRSVL SDGRHTFSPY
660 670 680 690 700
GLNILALPRI RKSHRLNSAD AAFVDERRKQ PMRKKEVRPL YHRLQQLHSV
710 720 730 740 750
DDSDDESRTP FTVDPDEQDS RPPSRMSSRS SDSDDGESAP EALDGFVSAQ
760 770 780 790 800
AKHGMDVLQT PVTEHTIDQY PHKDTPDSSL TCKRKRPAED VEARKRLKED
810 820 830 840 850
ECEHLNRNLP AETALDLSTL RVDHDVLGSV DHIDDYQKHS IQVSDKTIQA
860 870 880 890 900
HEDHEQTSDG TPDIDSIIQN AGIEVKLQSP DEHDNAERHD GMRTEVEWGV
910 920 930 940 950
SNNEPRSTVD DDETIVMDLD GWQALVKDEE DLCFLRDVLS GLPWSKVDNL
960 970 980 990 1000
SAWAWRQKEI KALSRPNETG PVHEEIKISG YYVCNFTGAA RTEGRKRILE
1010 1020 1030 1040 1050
SEKSKYLPHR IRVQKAREER EAKARSDPHA TAAEAARITA AKTISKSTSR
1060 1070 1080 1090 1100
STRVNNRRLV ADINAQKQAL PMQSGDGDAL RFNQLKKRKK PVRFARSAIH
1110 1120 1130 1140 1150
NWGLYAEENI SANDMIIEYV GEKVRQQVAD MRERQYLKSG IGSSYLFRID
1160 1170 1180 1190 1200
ENTVIDATKR GGIARFINHS CTPNCTAKII KVDGSKRIVI YALRDIERDE
1210 1220 1230
ELTYDYKFER EWDSDDRIPC LCGSTGCKGF LN
Length:1,232
Mass (Da):138,805
Last modified:January 23, 2007 - v1
Checksum:i73A6994363B9F738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11121.1.
RefSeqiXP_001272547.1. XM_001272546.1.

Genome annotation databases

EnsemblFungiiCADACLAT00008396; CADACLAP00008186; CADACLAG00008396.
GeneIDi4704868.
KEGGiact:ACLA_088100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA. Translation: EAW11121.1 .
RefSeqi XP_001272547.1. XM_001272546.1.

3D structure databases

ProteinModelPortali A1CE22.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00008186.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00008396 ; CADACLAP00008186 ; CADACLAG00008396 .
GeneIDi 4704868.
KEGGi act:ACLA_088100.

Phylogenomic databases

HOGENOMi HOG000181654.
KOi K11422.
OMAi DKTGYYI.
OrthoDBi EOG7P8PH3.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1Imported.

Entry informationi

Entry nameiA1CE22_ASPCL
AccessioniPrimary (citable) accession number: A1CE22
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3