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A1CE22 (A1CE22_ASPCL) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific PIRNR PIRNR037104

EC=2.1.1.43 PIRNR PIRNR037104
Gene names
ORF Names:ACLA_088100 EMBL EAW11121.1
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity. PIRNR PIRNR037104

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR037104 SAAS SAAS001214

Subunit structure

Component of the COMPASS (Set1C) complex By similarity. PIRNR PIRNR037104

Subcellular location

Nucleus By similarity PIRNR PIRNR037104.

Sequence similarities

Contains 1 SET domain.

Contains 1 post-SET domain. RuleBase RU004541

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Sequences

Sequence LengthMass (Da)Tools
A1CE22 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 73A6994363B9F738

FASTA1,232138,805
        10         20         30         40         50         60 
MSRTSAGYAD FFPTAPSVLQ QRRIKAPRDH SLIKDRPGSE PKDGQLPSPE NTIANISTNS 

        70         80         90        100        110        120 
STLEFPITTI HTGQEKTQSR ETGRINLDTT STGSSILSST LAQSSLAQLK ELQIDTLTPL 

       130        140        150        160        170        180 
TNAGSSPPQR SSPCQSKSAG GIAEYNKPSN FVTEEAKLVV TPLHTPPTPQ SQTPRGGDIK 

       190        200        210        220        230        240 
GSKLIYDPDI DKRSSKEKRR KPQYVDFVVS DPKSCPADPR LSISNYTRGA GCKQKTKYRP 

       250        260        270        280        290        300 
APYRLKQWPY DASTTLGPGP PIQIVVTGFD PLTPIAPISA LFSSFGEVSE INNRTDPITG 

       310        320        330        340        350        360 
RFLGVCSVRY KDSNSFRGAE SIPAATAARR AFLECKKEQR IGTRRIRVEL DRDGAVSDKI 

       370        380        390        400        410        420 
VAKTIESQRM GHRKNTVLEE AKLEPRLKRS EPPPTAPKGP SRSSTRPGLA IPEGPRASFV 

       430        440        450        460        470        480 
KPAVPSLVEE TPILSQIKRE PYIFIAHCYV PVLSTTVPHL KKRLKLFDWK DIRCDKTGYY 

       490        500        510        520        530        540 
IIFENSRRGE EETQRCFKVC HMKPLFTYIM NMESQPYGNP NYERSPSPER LQAERREKSE 

       550        560        570        580        590        600 
RERVKREADL DIEEEKQQRA INMDPCREVL ALIVRDLKDK LLEDVKSRIA APALYDYLDP 

       610        620        630        640        650        660 
ERHALKRQQL GLRDPEGIKK PAFRIDVEAS LGPGQSRSVL SDGRHTFSPY GLNILALPRI 

       670        680        690        700        710        720 
RKSHRLNSAD AAFVDERRKQ PMRKKEVRPL YHRLQQLHSV DDSDDESRTP FTVDPDEQDS 

       730        740        750        760        770        780 
RPPSRMSSRS SDSDDGESAP EALDGFVSAQ AKHGMDVLQT PVTEHTIDQY PHKDTPDSSL 

       790        800        810        820        830        840 
TCKRKRPAED VEARKRLKED ECEHLNRNLP AETALDLSTL RVDHDVLGSV DHIDDYQKHS 

       850        860        870        880        890        900 
IQVSDKTIQA HEDHEQTSDG TPDIDSIIQN AGIEVKLQSP DEHDNAERHD GMRTEVEWGV 

       910        920        930        940        950        960 
SNNEPRSTVD DDETIVMDLD GWQALVKDEE DLCFLRDVLS GLPWSKVDNL SAWAWRQKEI 

       970        980        990       1000       1010       1020 
KALSRPNETG PVHEEIKISG YYVCNFTGAA RTEGRKRILE SEKSKYLPHR IRVQKAREER 

      1030       1040       1050       1060       1070       1080 
EAKARSDPHA TAAEAARITA AKTISKSTSR STRVNNRRLV ADINAQKQAL PMQSGDGDAL 

      1090       1100       1110       1120       1130       1140 
RFNQLKKRKK PVRFARSAIH NWGLYAEENI SANDMIIEYV GEKVRQQVAD MRERQYLKSG 

      1150       1160       1170       1180       1190       1200 
IGSSYLFRID ENTVIDATKR GGIARFINHS CTPNCTAKII KVDGSKRIVI YALRDIERDE 

      1210       1220       1230 
ELTYDYKFER EWDSDDRIPC LCGSTGCKGF LN 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027052 Genomic DNA. Translation: EAW11121.1.
RefSeqXP_001272547.1. XM_001272546.1.

3D structure databases

ProteinModelPortalA1CE22.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00008186.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00008396; CADACLAP00008186; CADACLAG00008396.
GeneID4704868.
KEGGact:ACLA_088100.

Phylogenomic databases

HOGENOMHOG000181654.
KOK11422.
OMADKTGYYI.
OrthoDBEOG7P8PH3.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1CE22_ASPCL
AccessionPrimary (citable) accession number: A1CE22
Entry history
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)