UniProtKB - A1CE22 (A1CE22_ASPCL)
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Protein
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Gene
ACLA_088100
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Functioni
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation
Catalytic activityi
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation
GO - Molecular functioni
- histone-lysine N-methyltransferase activity Source: UniProtKB-UniRule
- nucleic acid binding Source: InterPro
Keywordsi
Molecular function | Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase |
Ligand | S-adenosyl-L-methionineUniRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation) |
Gene namesi | ORF Names:ACLA_088100Imported |
Organismi | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported |
Taxonomic identifieri | 344612 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:ACLA_088100 |
Subcellular locationi
Keywords - Cellular componenti
ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotationInteractioni
Subunit structurei
Component of the COMPASS (Set1C) complex.UniRule annotation
Protein-protein interaction databases
STRINGi | 5057.CADACLAP00008186 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1090 – 1207 | SETInterPro annotationAdd BLAST | 118 | |
Domaini | 1216 – 1232 | Post-SETInterPro annotationAdd BLAST | 17 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 536 – 556 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 788 – 808 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | HOG000181654 |
KOi | K11422 |
OMAi | HMKKRLK |
OrthoDBi | EOG092C3T9B |
Family and domain databases
Gene3Di | 3.30.70.3301 hit |
InterProi | View protein in InterPro IPR024657 COMPASS_Set1_N-SET IPR012677 Nucleotide-bd_a/b_plait_sf IPR003616 Post-SET_dom IPR035979 RBD_domain_sf IPR017111 Set1 IPR024636 SET_assoc IPR001214 SET_dom |
PANTHERi | PTHR22884:SF462 PTHR22884:SF462, 1 hit |
Pfami | View protein in Pfam PF11764 N-SET, 1 hit PF00856 SET, 1 hit PF11767 SET_assoc, 1 hit |
PIRSFi | PIRSF037104 Histone_H3-K4_mtfrase_Set1_fun, 2 hits |
SMARTi | View protein in SMART SM01291 N-SET, 1 hit SM00508 PostSET, 1 hit SM00317 SET, 1 hit |
SUPFAMi | SSF54928 SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50868 POST_SET, 1 hit PS51572 SAM_MT43_1, 1 hit PS50280 SET, 1 hit |
i Sequence
Sequence statusi: Complete.
A1CE22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRTSAGYAD FFPTAPSVLQ QRRIKAPRDH SLIKDRPGSE PKDGQLPSPE
60 70 80 90 100
NTIANISTNS STLEFPITTI HTGQEKTQSR ETGRINLDTT STGSSILSST
110 120 130 140 150
LAQSSLAQLK ELQIDTLTPL TNAGSSPPQR SSPCQSKSAG GIAEYNKPSN
160 170 180 190 200
FVTEEAKLVV TPLHTPPTPQ SQTPRGGDIK GSKLIYDPDI DKRSSKEKRR
210 220 230 240 250
KPQYVDFVVS DPKSCPADPR LSISNYTRGA GCKQKTKYRP APYRLKQWPY
260 270 280 290 300
DASTTLGPGP PIQIVVTGFD PLTPIAPISA LFSSFGEVSE INNRTDPITG
310 320 330 340 350
RFLGVCSVRY KDSNSFRGAE SIPAATAARR AFLECKKEQR IGTRRIRVEL
360 370 380 390 400
DRDGAVSDKI VAKTIESQRM GHRKNTVLEE AKLEPRLKRS EPPPTAPKGP
410 420 430 440 450
SRSSTRPGLA IPEGPRASFV KPAVPSLVEE TPILSQIKRE PYIFIAHCYV
460 470 480 490 500
PVLSTTVPHL KKRLKLFDWK DIRCDKTGYY IIFENSRRGE EETQRCFKVC
510 520 530 540 550
HMKPLFTYIM NMESQPYGNP NYERSPSPER LQAERREKSE RERVKREADL
560 570 580 590 600
DIEEEKQQRA INMDPCREVL ALIVRDLKDK LLEDVKSRIA APALYDYLDP
610 620 630 640 650
ERHALKRQQL GLRDPEGIKK PAFRIDVEAS LGPGQSRSVL SDGRHTFSPY
660 670 680 690 700
GLNILALPRI RKSHRLNSAD AAFVDERRKQ PMRKKEVRPL YHRLQQLHSV
710 720 730 740 750
DDSDDESRTP FTVDPDEQDS RPPSRMSSRS SDSDDGESAP EALDGFVSAQ
760 770 780 790 800
AKHGMDVLQT PVTEHTIDQY PHKDTPDSSL TCKRKRPAED VEARKRLKED
810 820 830 840 850
ECEHLNRNLP AETALDLSTL RVDHDVLGSV DHIDDYQKHS IQVSDKTIQA
860 870 880 890 900
HEDHEQTSDG TPDIDSIIQN AGIEVKLQSP DEHDNAERHD GMRTEVEWGV
910 920 930 940 950
SNNEPRSTVD DDETIVMDLD GWQALVKDEE DLCFLRDVLS GLPWSKVDNL
960 970 980 990 1000
SAWAWRQKEI KALSRPNETG PVHEEIKISG YYVCNFTGAA RTEGRKRILE
1010 1020 1030 1040 1050
SEKSKYLPHR IRVQKAREER EAKARSDPHA TAAEAARITA AKTISKSTSR
1060 1070 1080 1090 1100
STRVNNRRLV ADINAQKQAL PMQSGDGDAL RFNQLKKRKK PVRFARSAIH
1110 1120 1130 1140 1150
NWGLYAEENI SANDMIIEYV GEKVRQQVAD MRERQYLKSG IGSSYLFRID
1160 1170 1180 1190 1200
ENTVIDATKR GGIARFINHS CTPNCTAKII KVDGSKRIVI YALRDIERDE
1210 1220 1230
ELTYDYKFER EWDSDDRIPC LCGSTGCKGF LN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS027052 Genomic DNA Translation: EAW11121.1 |
RefSeqi | XP_001272547.1, XM_001272546.1 |
Genome annotation databases
EnsemblFungii | CADACLAT00008396; CADACLAP00008186; CADACLAG00008396 |
GeneIDi | 4704868 |
KEGGi | act:ACLA_088100 |
Similar proteinsi
Entry informationi
Entry namei | A1CE22_ASPCL | |
Accessioni | A1CE22Primary (citable) accession number: A1CE22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 23, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |