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A1CD22 (EGLC_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glucan endo-1,3-beta-glucosidase eglC

EC=3.2.1.39
Alternative name(s):
Endo-1,3-beta-glucanase eglC
Laminarinase eglC
Gene names
Name:eglC
ORF Names:ACLA_064000
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase By similarity.

Catalytic activity

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity. Note: Covalently-linked GPI-modified cell wall protein By similarity.

Post-translational modification

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 430412Probable glucan endo-1,3-beta-glucosidase eglC
PRO_0000395138
Propeptide431 – 45323Removed in mature form Potential
PRO_0000395139

Regions

Compositional bias309 – 438130Ser-rich

Sites

Active site1281Nucleophile By similarity
Active site2391Proton donor By similarity

Amino acid modifications

Lipidation4301GPI-anchor amidated asparagine Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Glycosylation3761N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CD22 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 0A1ACC08C6AA896A

FASTA45345,031
        10         20         30         40         50         60 
MQTRQLLALA LAVAATEAAH QGFNYGNTKS DGSAKSQSDF AAEFSTAKNL VGTSGFTSAR 

        70         80         90        100        110        120 
LYTMIQGGTS ATPISAIPAA IAEDTSLLLG IWASGGNVAN EIAALKAAIA QYGADFGKHV 

       130        140        150        160        170        180 
VGISVGSEDL YRNSVDGVKS KAGLGANPDD LVSYIHQVRE AIAGTSLSGA PIGHVDTWTA 

       190        200        210        220        230        240 
WVNGSNSAVI DACDWLGFDG YPYFQNTMPN SISDAKALFD ESVAKTQAVA KGKEVWITET 

       250        260        270        280        290        300 
GWPVSGKTEN LAVANTANAK AYWDQVGCPL FGNTNTWWYI LQDADPVTPN PSFGIVGSTL 

       310        320        330        340        350        360 
STTPLFDLSC SAVSSSSAVP SATAAATAAS GAGASGSQTS GFATAAAGSS SAAKPTFSVG 

       370        380        390        400        410        420 
KGPNGSYNGT YPGSWNSTRP GANGGSSGSS GSSGSSGSSG SSGSSGSGAS GHSSSTGSSS 

       430        440        450 
FPSSTNLLSN SASGLSGSLF GAVAAVFVAL AAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027050 Genomic DNA. Translation: EAW12429.1.
RefSeqXP_001273855.1. XM_001273854.1.

3D structure databases

ProteinModelPortalA1CD22.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00006072; CADACLAP00005935; CADACLAG00006072.
GeneID4705814.
KEGGact:ACLA_064000.

Phylogenomic databases

eggNOGCOG5309.
HOGENOMHOG000179527.
OMATNTWWYI.
OrthoDBEOG7TBCCK.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEGLC_ASPCL
AccessionPrimary (citable) accession number: A1CD22
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries