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A1CD22

- EGLC_ASPCL

UniProt

A1CD22 - EGLC_ASPCL

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Protein

Probable glucan endo-1,3-beta-glucosidase eglC

Gene

eglC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281NucleophileBy similarity
Active sitei239 – 2391Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan endo-1,3-beta-glucosidase eglC (EC:3.2.1.39)
Alternative name(s):
Endo-1,3-beta-glucanase eglC
Laminarinase eglC
Gene namesi
Name:eglC
ORF Names:ACLA_064000
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity
Note: Covalently-linked GPI-modified cell wall protein.By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell wall Source: UniProtKB-KW
  3. extracellular region Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 430412Probable glucan endo-1,3-beta-glucosidase eglCPRO_0000395138Add
BLAST
Propeptidei431 – 45323Removed in mature formSequence AnalysisPRO_0000395139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
Lipidationi430 – 4301GPI-anchor amidated asparagineSequence Analysis

Post-translational modificationi

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity).By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA1CD22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi309 – 438130Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000179527.
OMAiTNTWWYI.
OrthoDBiEOG7TBCCK.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CD22-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTRQLLALA LAVAATEAAH QGFNYGNTKS DGSAKSQSDF AAEFSTAKNL
60 70 80 90 100
VGTSGFTSAR LYTMIQGGTS ATPISAIPAA IAEDTSLLLG IWASGGNVAN
110 120 130 140 150
EIAALKAAIA QYGADFGKHV VGISVGSEDL YRNSVDGVKS KAGLGANPDD
160 170 180 190 200
LVSYIHQVRE AIAGTSLSGA PIGHVDTWTA WVNGSNSAVI DACDWLGFDG
210 220 230 240 250
YPYFQNTMPN SISDAKALFD ESVAKTQAVA KGKEVWITET GWPVSGKTEN
260 270 280 290 300
LAVANTANAK AYWDQVGCPL FGNTNTWWYI LQDADPVTPN PSFGIVGSTL
310 320 330 340 350
STTPLFDLSC SAVSSSSAVP SATAAATAAS GAGASGSQTS GFATAAAGSS
360 370 380 390 400
SAAKPTFSVG KGPNGSYNGT YPGSWNSTRP GANGGSSGSS GSSGSSGSSG
410 420 430 440 450
SSGSSGSGAS GHSSSTGSSS FPSSTNLLSN SASGLSGSLF GAVAAVFVAL

AAL
Length:453
Mass (Da):45,031
Last modified:January 23, 2007 - v1
Checksum:i0A1ACC08C6AA896A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027050 Genomic DNA. Translation: EAW12429.1.
RefSeqiXP_001273855.1. XM_001273854.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006072; CADACLAP00005935; CADACLAG00006072.
GeneIDi4705814.
KEGGiact:ACLA_064000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027050 Genomic DNA. Translation: EAW12429.1 .
RefSeqi XP_001273855.1. XM_001273854.1.

3D structure databases

ProteinModelPortali A1CD22.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00006072 ; CADACLAP00005935 ; CADACLAG00006072 .
GeneIDi 4705814.
KEGGi act:ACLA_064000.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000179527.
OMAi TNTWWYI.
OrthoDBi EOG7TBCCK.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiEGLC_ASPCL
AccessioniPrimary (citable) accession number: A1CD22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3