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A1CBW8

- AGALA_ASPCL

UniProt

A1CBW8 - AGALA_ASPCL

Protein

Probable alpha-galactosidase A

Gene

aglA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei148 – 1481NucleophileBy similarity
    Active sitei206 – 2061Proton donorBy similarity

    GO - Molecular functioni

    1. raffinose alpha-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable alpha-galactosidase A (EC:3.2.1.22)
    Alternative name(s):
    Melibiase A
    Gene namesi
    Name:aglA
    ORF Names:ACLA_016820
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 525508Probable alpha-galactosidase APRO_0000393213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 72PROSITE-ProRule annotation
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 150PROSITE-ProRule annotation
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi422 ↔ 434PROSITE-ProRule annotation
    Disulfide bondi459 ↔ 472PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00001524.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CBW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini402 – 525124Ricin B-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 27 family.Curated
    Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68897.
    HOGENOMiHOG000161224.
    KOiK07407.
    OMAiGFNNWAR.
    OrthoDBiEOG7SR4WK.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR013780. Glyco_hydro_13_b.
    IPR002241. Glyco_hydro_27.
    IPR000111. Glyco_hydro_GHD.
    IPR017853. Glycoside_hydrolase_SF.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF02065. Melibiase. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view]
    PRINTSiPR00740. GLHYDRLASE27.
    SMARTiSM00458. RICIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CBW8-1 [UniParc]FASTAAdd to Basket

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    MHPSMTLLAI LPPLVRASIG NPHLLPTPPM GFNNWARFMC NLNESLFLDT    50
    AAAMLDTGLH AAGYTRLNLD DCWMASHRAP NGSLPWDPTK FPHSLPWLSA 100
    QLRSLGFSLG IYQDAGNVTC GGYPGSYGFE ELDAHTFAEW GVDYLKLDGC 150
    NVSPAGAVSL ADEYRARYAR WHSVLGAMPH PLVFSESAPA YFVDPQNATA 200
    WYGVMDWVPA YGELARHSTD ILVYEGEGSA WQSIMVNYRY NTLLARYQRP 250
    GYFNDPDFLI ADHPGLSLVE KRSHFALWAS FGAPLIISAD VPGLSKEVIA 300
    VLTNADLIRV DQDALGLQAT LASRSEHLDV LTRSLDGGDR LVTILNRGDG 350
    GLAVKVPVGW MGLQRCAYQA KNLWDGEIQE IEEDIEVQLD SHATEVFRVS 400
    LPPDCPMVIP TGIVFNTASG NCLTDGEALA FEPCRGQDLQ VWQVEESGIL 450
    RPLSRTSHCL TAIGDNVVVK PCTGRPGQRW TYHITGNLQN QHTGACLTEG 500
    TGIDVCGFEL DSQVFGLPSG VDIEA 525
    Length:525
    Mass (Da):57,347
    Last modified:January 23, 2007 - v1
    Checksum:iDBDD564471DEF811
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027049 Genomic DNA. Translation: EAW13236.1.
    RefSeqiXP_001274662.1. XM_001274661.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00001543; CADACLAP00001524; CADACLAG00001543.
    GeneIDi4706882.
    KEGGiact:ACLA_016820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027049 Genomic DNA. Translation: EAW13236.1 .
    RefSeqi XP_001274662.1. XM_001274661.1.

    3D structure databases

    ProteinModelPortali A1CBW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00001524.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00001543 ; CADACLAP00001524 ; CADACLAG00001543 .
    GeneIDi 4706882.
    KEGGi act:ACLA_016820.

    Phylogenomic databases

    eggNOGi NOG68897.
    HOGENOMi HOG000161224.
    KOi K07407.
    OMAi GFNNWAR.
    OrthoDBi EOG7SR4WK.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR013780. Glyco_hydro_13_b.
    IPR002241. Glyco_hydro_27.
    IPR000111. Glyco_hydro_GHD.
    IPR017853. Glycoside_hydrolase_SF.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF02065. Melibiase. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view ]
    PRINTSi PR00740. GLHYDRLASE27.
    SMARTi SM00458. RICIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiAGALA_ASPCL
    AccessioniPrimary (citable) accession number: A1CBW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3