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A1CBW8 (AGALA_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable alpha-galactosidase A

EC=3.2.1.22
Alternative name(s):
Melibiase A
Gene names
Name:aglA
ORF Names:ACLA_016820
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 27 family.

Contains 1 ricin B-type lectin domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandLectin
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionraffinose alpha-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 525508Probable alpha-galactosidase A
PRO_0000393213

Regions

Domain402 – 525124Ricin B-type lectin

Sites

Active site1481Nucleophile By similarity
Active site2061Proton donor By similarity

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation811N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 72 By similarity
Disulfide bond120 ↔ 150 By similarity
Disulfide bond422 ↔ 434 By similarity
Disulfide bond459 ↔ 472 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1CBW8 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: DBDD564471DEF811

FASTA52557,347
        10         20         30         40         50         60 
MHPSMTLLAI LPPLVRASIG NPHLLPTPPM GFNNWARFMC NLNESLFLDT AAAMLDTGLH 

        70         80         90        100        110        120 
AAGYTRLNLD DCWMASHRAP NGSLPWDPTK FPHSLPWLSA QLRSLGFSLG IYQDAGNVTC 

       130        140        150        160        170        180 
GGYPGSYGFE ELDAHTFAEW GVDYLKLDGC NVSPAGAVSL ADEYRARYAR WHSVLGAMPH 

       190        200        210        220        230        240 
PLVFSESAPA YFVDPQNATA WYGVMDWVPA YGELARHSTD ILVYEGEGSA WQSIMVNYRY 

       250        260        270        280        290        300 
NTLLARYQRP GYFNDPDFLI ADHPGLSLVE KRSHFALWAS FGAPLIISAD VPGLSKEVIA 

       310        320        330        340        350        360 
VLTNADLIRV DQDALGLQAT LASRSEHLDV LTRSLDGGDR LVTILNRGDG GLAVKVPVGW 

       370        380        390        400        410        420 
MGLQRCAYQA KNLWDGEIQE IEEDIEVQLD SHATEVFRVS LPPDCPMVIP TGIVFNTASG 

       430        440        450        460        470        480 
NCLTDGEALA FEPCRGQDLQ VWQVEESGIL RPLSRTSHCL TAIGDNVVVK PCTGRPGQRW 

       490        500        510        520 
TYHITGNLQN QHTGACLTEG TGIDVCGFEL DSQVFGLPSG VDIEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027049 Genomic DNA. Translation: EAW13236.1.
RefSeqXP_001274662.1. XM_001274661.1.

3D structure databases

ProteinModelPortalA1CBW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00001524.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00001543; CADACLAP00001524; CADACLAG00001543.
GeneID4706882.
KEGGact:ACLA_016820.

Phylogenomic databases

eggNOGNOG68897.
HOGENOMHOG000161224.
KOK07407.
OMAESAPAYF.
OrthoDBEOG7SR4WK.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamPF02065. Melibiase. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSPR00740. GLHYDRLASE27.
SMARTSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMSSF50370. SSF50370. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAGALA_ASPCL
AccessionPrimary (citable) accession number: A1CBW8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries