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A1CBW8

- AGALA_ASPCL

UniProt

A1CBW8 - AGALA_ASPCL

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Protein

Probable alpha-galactosidase A

Gene
aglA, ACLA_016820
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481Nucleophile By similarity
Active sitei206 – 2061Proton donor By similarity

GO - Molecular functioni

  1. raffinose alpha-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-galactosidase A (EC:3.2.1.22)
Alternative name(s):
Melibiase A
Gene namesi
Name:aglA
ORF Names:ACLA_016820
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 525508Probable alpha-galactosidase APRO_0000393213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 72 By similarity
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi120 ↔ 150 By similarity
Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi422 ↔ 434 By similarity
Disulfide bondi459 ↔ 472 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00001524.

Structurei

3D structure databases

ProteinModelPortaliA1CBW8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini402 – 525124Ricin B-type lectinAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68897.
HOGENOMiHOG000161224.
KOiK07407.
OMAiGFNNWAR.
OrthoDBiEOG7SR4WK.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF02065. Melibiase. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSiPR00740. GLHYDRLASE27.
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CBW8-1 [UniParc]FASTAAdd to Basket

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MHPSMTLLAI LPPLVRASIG NPHLLPTPPM GFNNWARFMC NLNESLFLDT    50
AAAMLDTGLH AAGYTRLNLD DCWMASHRAP NGSLPWDPTK FPHSLPWLSA 100
QLRSLGFSLG IYQDAGNVTC GGYPGSYGFE ELDAHTFAEW GVDYLKLDGC 150
NVSPAGAVSL ADEYRARYAR WHSVLGAMPH PLVFSESAPA YFVDPQNATA 200
WYGVMDWVPA YGELARHSTD ILVYEGEGSA WQSIMVNYRY NTLLARYQRP 250
GYFNDPDFLI ADHPGLSLVE KRSHFALWAS FGAPLIISAD VPGLSKEVIA 300
VLTNADLIRV DQDALGLQAT LASRSEHLDV LTRSLDGGDR LVTILNRGDG 350
GLAVKVPVGW MGLQRCAYQA KNLWDGEIQE IEEDIEVQLD SHATEVFRVS 400
LPPDCPMVIP TGIVFNTASG NCLTDGEALA FEPCRGQDLQ VWQVEESGIL 450
RPLSRTSHCL TAIGDNVVVK PCTGRPGQRW TYHITGNLQN QHTGACLTEG 500
TGIDVCGFEL DSQVFGLPSG VDIEA 525
Length:525
Mass (Da):57,347
Last modified:January 23, 2007 - v1
Checksum:iDBDD564471DEF811
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW13236.1.
RefSeqiXP_001274662.1. XM_001274661.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001543; CADACLAP00001524; CADACLAG00001543.
GeneIDi4706882.
KEGGiact:ACLA_016820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW13236.1 .
RefSeqi XP_001274662.1. XM_001274661.1.

3D structure databases

ProteinModelPortali A1CBW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00001524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00001543 ; CADACLAP00001524 ; CADACLAG00001543 .
GeneIDi 4706882.
KEGGi act:ACLA_016820.

Phylogenomic databases

eggNOGi NOG68897.
HOGENOMi HOG000161224.
KOi K07407.
OMAi GFNNWAR.
OrthoDBi EOG7SR4WK.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF02065. Melibiase. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
PRINTSi PR00740. GLHYDRLASE27.
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiAGALA_ASPCL
AccessioniPrimary (citable) accession number: A1CBW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi