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Protein

Aspartic protease pep1

Gene

pep1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. Can catalyze hydrolysis of the major structural proteins of basement membrane, elastin, collagen, and laminin (By similarity).By similarity

Catalytic activityi

Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011PROSITE-ProRule annotation
Active sitei283 – 2831PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease pep1 (EC:3.4.23.18)
Alternative name(s):
Aspergillopepsin A
Aspergillopepsin I
Gene namesi
Name:pep1
Synonyms:pepA
ORF Names:ACLA_016280
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_016280.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 6949Activation peptideBy similarityPRO_0000407039Add
BLAST
Chaini70 – 394325Aspartic protease pep1PRO_0000407040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi319 ↔ 354By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliA1CBR4.
SMRiA1CBR4. Positions 70-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 391307Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000167484.
KOiK06004.
OMAiFTINQVA.
OrthoDBiEOG092C49YE.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CBR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVFSKVTAA VFGLATIASA APAPPTRKGF TVQQQARPAQ KKQVNLPAMY
60 70 80 90 100
AHALTKFGGS VPESVKVAAS KGSAVTTPEA GDVEYLTPVN VGGTVMNLDF
110 120 130 140 150
DTGSADLWVF SGELPASETS GHSVYKPGRT ASKLPGGSWQ ISYGDGSSAS
160 170 180 190 200
GDVYKDTVVV GGVTAHGQAV EAAAQISSQF LQDKNNDGLL GLAFSSLNTV
210 220 230 240 250
QPQPQTTFFD TVKSSLDRPL FAVTLKHNAP GSFDFGYIDH SKYTGEIAYT
260 270 280 290 300
DVDNSQGFWS FTADGYSIGG GQSSGSSISG IADTGTTLLL LDDNVVSDFY
310 320 330 340 350
QHVEGAQNSD EYGGYVFPCS AKVPSFTTII GGYKAVTPGK LINYGPVTDG
360 370 380 390
SSTCYGGIQS SGGVGQNIFG DIFLKSQFVV FDSEGPRLGF AAQA
Length:394
Mass (Da):40,934
Last modified:January 23, 2007 - v1
Checksum:iC5E9F9851AAEFBA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027049 Genomic DNA. Translation: EAW13182.1.
RefSeqiXP_001274608.1. XM_001274607.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001470; CADACLAP00001451; CADACLAG00001470.
GeneIDi4706595.
KEGGiact:ACLA_016280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027049 Genomic DNA. Translation: EAW13182.1.
RefSeqiXP_001274608.1. XM_001274607.1.

3D structure databases

ProteinModelPortaliA1CBR4.
SMRiA1CBR4. Positions 70-394.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA01.026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00001470; CADACLAP00001451; CADACLAG00001470.
GeneIDi4706595.
KEGGiact:ACLA_016280.

Organism-specific databases

EuPathDBiFungiDB:ACLA_016280.

Phylogenomic databases

HOGENOMiHOG000167484.
KOiK06004.
OMAiFTINQVA.
OrthoDBiEOG092C49YE.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 2 hits.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPA_ASPCL
AccessioniPrimary (citable) accession number: A1CBR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.