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A1CBC9

- DCL1_ASPCL

UniProt

A1CBC9 - DCL1_ASPCL

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Protein
Dicer-like protein 1
Gene
dcl1, ACLA_014840
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1291 – 12911Magnesium or manganese By similarity
Sitei1384 – 13841Important for activity By similarity
Metal bindingi1388 – 13881Magnesium or manganese By similarity
Metal bindingi1391 – 13911Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1508ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. RNA binding Source: UniProtKB-KW
  4. helicase activity Source: UniProtKB-KW
  5. metal ion binding Source: UniProtKB-KW
  6. ribonuclease III activity Source: InterPro

GO - Biological processi

  1. RNA processing Source: InterPro
  2. defense response to virus Source: UniProtKB-KW
  3. regulation of defense response to virus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 1
Including the following 2 domains:
Endoribonuclease dcl1 (EC:3.1.26.-)
ATP-dependent helicase dcl1 (EC:3.6.4.-)
Gene namesi
Name:dcl1
ORF Names:ACLA_014840
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15341534Dicer-like protein 1
PRO_0000306773Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00001180.

Structurei

3D structure databases

ProteinModelPortaliA1CBC9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 311182Helicase ATP-binding
Add
BLAST
Domaini456 – 613158Helicase C-terminal
Add
BLAST
Domaini648 – 73891Dicer dsRNA-binding fold
Add
BLAST
Domaini1054 – 1199146RNase III 1
Add
BLAST
Domaini1250 – 1402153RNase III 2
Add
BLAST
Domaini1436 – 150469DRBM
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi256 – 2594DEAH box

Sequence similaritiesi

Contains 2 RNase III domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000048448.
KOiK11592.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CBC9-1 [UniParc]FASTAAdd to Basket

« Hide

MSSDLISQAE SISNIEILRA LFITDTHTTV GDVAVPSAEP GVEHDQISPG     50
ESDEEIEENI SDQNNSSSQK RLQNAQFEAL LTRRAEDTSN ENIDRVPLNL 100
SDNELSIAHL VAKQDVGGGL LDPREYQIEL FERAKAQNTI AVLDTGSGKT 150
LIAVLLLRHV LQNELNDRAN GKPHRVSFFL VDSVTLAYQQ AAVLRNNIDQ 200
NVAHFFGAMG TDLWDRQVWE EHLQQNMVIV CTAEILNQCL LNSHVRMNQI 250
NLLIFDEAHH TKKDHPYARI IRDSYFKASP PQRPRIFGMT ASPIDTKGDI 300
IAAATRLETL LDSRIATTSK ITLLRQVVSR PIEKVWAYDR LESPFKTNLH 350
KLMENRFGNV KALEGVFRFA WYASSELGRW CSDRAWLYAL ADDVLPKLEG 400
HVNKLAESTA AATERDMAFK EITLIKEASN IVKAHTFNDP EFPGELSPKV 450
RLLQTELSKH FSHAPETKCI IFTQKRYTAK TLHELFTILS IPHLRPGVLI 500
GVRSGDIGGM NITFRQQFLA LVKFRKGEIN CLFATSVAEE GLDIPDCNLV 550
VRFDLYHTLI QYVQSRGRAR HYHSTYASMV EKDNSDHEAR LREVREAEKT 600
MQNFCETLPE DRILHGNDHD LDSLLQHEEG RRTFTVKSTG ARLTYHSAIA 650
ILARYASSLQ YEKETTPQAT YVVQSVGNTY VCEVILPEKS PIRGLTGSPA 700
IRKSIAKQSA AFDTCLLLRR HKLLDDFFKS IYHKRLPAMR NAKLAITSKK 750
TNQYDMLLKP SIWRRHQGIL PSKLYGTILS LLPSEPLSRE HQPILVLTRE 800
KLPDFPAFPI YLDEDIETKV VPRSLDTGME LSAEELRALT TFTLRIFRDV 850
FHKVYEQESE KLPYWLAPAE PLDANGREPG PRGIIDWKTV TFVQENDEIV 900
FSRDLAPESL VNRFMFDKWD GRSRFFTIKV MEGLRAADPP PSSVPRRRHM 950
DNIMSYCLSL SKNSRARFLA GCHWDQPVLQ AELVRLRRNL LDKLTTEEKK 1000
IQTECFICAE PLKISAIPPS IASTCLAFPA IITRLDSYLI SIEACDELDL 1050
VIRSDYALEA VTKDSDNTEE HRGQQIHFQR GMGKNYERLE FLGDCFLKMA 1100
TSIALFTQNP DDDEFDYHVN RMCLICNKNL FNTAKKRQIY RYIRSRSFSR 1150
HVWYPDGLTL LQGKDHSKKM LSQAKHALGE KTIADVCEAL IGACLLSGGP 1200
EHRFDMGVKA VSVFVDSPSH AVSRWKEYIG LYKPPNYQVR KAEGAETNLA 1250
LQVEEKLGYH FRYPRLLCSA VTHPSTPSTW YFRVPCYQRL EFLGDSLLDM 1300
VCVEDLFHRF PDRDPQWLTE HKMAMVSNKF LGALAVKLGF HKHIKAFSNP 1350
LQAQITYYVE EIETAEAESE GAVDYWVVAK DPPKCLPDMV EAYLGAIFVD 1400
SDFSFEVIEA FFQAQIKPYF QDMSIYDTFA NKHPTTFLHN RLANEFGCTN 1450
YCLKAGEMPA IDGMPAGVLA AVIVHNSVVS EATASSSRYA KIRASERALV 1500
VLDGLLPYEF RQRYNCNCQV VGNPASAPDI GTAI 1534
Length:1,534
Mass (Da):174,094
Last modified:October 2, 2007 - v2
Checksum:i200457CEAAB4115B
GO

Sequence cautioni

The sequence EAW13047.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW13047.1. Sequence problems.
RefSeqiXP_001274473.1. XM_001274472.1.

Genome annotation databases

GeneIDi4706314.
KEGGiact:ACLA_014840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW13047.1 . Sequence problems.
RefSeqi XP_001274473.1. XM_001274472.1.

3D structure databases

ProteinModelPortali A1CBC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00001180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4706314.
KEGGi act:ACLA_014840.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000048448.
KOi K11592.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR005034. Dicer_dimerisation_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDCL1_ASPCL
AccessioniPrimary (citable) accession number: A1CBC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi