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A1CAU3

- XKS1_ASPCL

UniProt

A1CAU3 - XKS1_ASPCL

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Protein
Probable D-xylulose kinase A
Gene
xkiA, ACLA_012890
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei284 – 2841Substrate By similarity
Binding sitei285 – 2851Substrate By similarity
Binding sitei366 – 3661ATP By similarity
Binding sitei475 – 4751ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi471 – 4722ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:ACLA_012890
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Probable D-xylulose kinase A
PRO_0000393516Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00001387.

Structurei

3D structure databases

ProteinModelPortaliA1CAU3.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CAU3-1 [UniParc]FASTAAdd to Basket

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MASQGPLYIG FDLSTQQLKG LVVNSELKVV HISKFDFDAD SRGFSIKKGV    50
LTNEAEHEVF APVALWLQAL DGVLDGLRKQ GLDFSRVRGI SGAGQQHGSV 100
YWGENAEKLL GGLDAGKTLE EQLSGAFSHP FSPNWQDAST QKECDEFDAV 150
LGGPEQLAEA TGSKAHHRFT GPQILRFQRK YPEVYKKTSR ISLVSSFLAS 200
LLLGHIAPMD ISDVCGMNLW NIRKGAYDED LLKLCAGPFG MEDLKRKLGD 250
VPEDGGLHLG KINKYYIDRY GFSSDCEILP STGDNPATIL ALPLRPSDAM 300
VSLGTSTTFL MSTPSYKPDP ATHFFNHPTT PGLYMFMLCY KNGGLAREHV 350
RDAINEKLGS PASQSWENFD RITLETPPLG QKSESDPMKL GLFFPRPEIV 400
PNLRSGQWRF NYNPANETLT ESNDGWNNPS DEARAIVESQ MLSLRLRSRG 450
LTQSPGAKIP PQPRRVYLVG GGSKNKAIAK VAGEILGGSD GVYKLDVGDN 500
ACALGAAYKA VWAMERTPGQ TFEDLIGQRW REEEFIEKIA DGYQKGVFEK 550
YGNAVEGFEK MEHQVLEQEA ARK 573
Length:573
Mass (Da):63,148
Last modified:January 23, 2007 - v1
Checksum:i2248064E535829B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW12861.1.
RefSeqiXP_001274287.1. XM_001274286.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001406; CADACLAP00001387; CADACLAG00001406.
GeneIDi4706424.
KEGGiact:ACLA_012890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW12861.1 .
RefSeqi XP_001274287.1. XM_001274286.1.

3D structure databases

ProteinModelPortali A1CAU3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00001387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00001406 ; CADACLAP00001387 ; CADACLAG00001406 .
GeneIDi 4706424.
KEGGi act:ACLA_012890.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000174850.
KOi K00854.
OMAi GSYSPID.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiXKS1_ASPCL
AccessioniPrimary (citable) accession number: A1CAU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi