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A1CAL7

- SHO1_ASPCL

UniProt

A1CAL7 - SHO1_ASPCL

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Protein

High osmolarity signaling protein sho1

Gene

sho1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.By similarity

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
High osmolarity signaling protein sho1
Alternative name(s):
Osmosensor sho1
Gene namesi
Name:sho1
ORF Names:ACLA_012130
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Topological domaini36 – 4611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Topological domaini68 – 692CytoplasmicSequence Analysis
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Topological domaini91 – 10414ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 292167CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292High osmolarity signaling protein sho1PRO_0000410358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Forms homooligomers.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00001234.

Structurei

3D structure databases

ProteinModelPortaliA1CAL7.
SMRiA1CAL7. Positions 234-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini233 – 29260SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SHO1 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000174182.
KOiK11246.
OMAiGSDTIQT.
OrthoDBiEOG7MPRR4.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CAL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARFRASNIL GDPFALATIS IAILAWIIAF ISSIIANIKM ADYPNHAWWA
60 70 80 90 100
IAYMFCCTIG VTVVVGSDTG LVYGVAVVGY LSAGLVLTSL SVNTLVYKGN
110 120 130 140 150
SSAQAAAAGF ILLSMIIIVW IFYFGSTPQA THRGFIDSFA LNKEGGNAYG
160 170 180 190 200
NGRPISTAFG HRPETTSTSA PQMYTSAQLN GFETSSPISG YPGGAPGSEN
210 220 230 240 250
RSSSQPRFGN PSASNLPANN NGQSQDEVPQ PTEYPYRAKA IYSYDANPED
260 270 280 290
ANEISFSKHE ILEVSDVSGR WWQARKSSGE TGIAPSNYLI LL
Length:292
Mass (Da):31,192
Last modified:January 23, 2007 - v1
Checksum:iAD1484F9079AD04A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027049 Genomic DNA. Translation: EAW12785.1.
RefSeqiXP_001274211.1. XM_001274210.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001253; CADACLAP00001234; CADACLAG00001253.
GeneIDi4706489.
KEGGiact:ACLA_012130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027049 Genomic DNA. Translation: EAW12785.1 .
RefSeqi XP_001274211.1. XM_001274210.1.

3D structure databases

ProteinModelPortali A1CAL7.
SMRi A1CAL7. Positions 234-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00001234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00001253 ; CADACLAP00001234 ; CADACLAG00001253 .
GeneIDi 4706489.
KEGGi act:ACLA_012130.

Phylogenomic databases

HOGENOMi HOG000174182.
KOi K11246.
OMAi GSDTIQT.
OrthoDBi EOG7MPRR4.

Family and domain databases

InterProi IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiSHO1_ASPCL
AccessioniPrimary (citable) accession number: A1CAL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3