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A1CAL7

- SHO1_ASPCL

UniProt

A1CAL7 - SHO1_ASPCL

Protein

High osmolarity signaling protein sho1

Gene

sho1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.By similarity

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High osmolarity signaling protein sho1
    Alternative name(s):
    Osmosensor sho1
    Gene namesi
    Name:sho1
    ORF Names:ACLA_012130
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292High osmolarity signaling protein sho1PRO_0000410358Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Forms homooligomers.By similarity

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00001234.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CAL7.
    SMRiA1CAL7. Positions 234-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 4611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 692CytoplasmicSequence Analysis
    Topological domaini91 – 10414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 292167CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini233 – 29260SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SHO1 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000174182.
    KOiK11246.
    OMAiGSDTIQT.
    OrthoDBiEOG7MPRR4.

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1CAL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARFRASNIL GDPFALATIS IAILAWIIAF ISSIIANIKM ADYPNHAWWA    50
    IAYMFCCTIG VTVVVGSDTG LVYGVAVVGY LSAGLVLTSL SVNTLVYKGN 100
    SSAQAAAAGF ILLSMIIIVW IFYFGSTPQA THRGFIDSFA LNKEGGNAYG 150
    NGRPISTAFG HRPETTSTSA PQMYTSAQLN GFETSSPISG YPGGAPGSEN 200
    RSSSQPRFGN PSASNLPANN NGQSQDEVPQ PTEYPYRAKA IYSYDANPED 250
    ANEISFSKHE ILEVSDVSGR WWQARKSSGE TGIAPSNYLI LL 292
    Length:292
    Mass (Da):31,192
    Last modified:January 23, 2007 - v1
    Checksum:iAD1484F9079AD04A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027049 Genomic DNA. Translation: EAW12785.1.
    RefSeqiXP_001274211.1. XM_001274210.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00001253; CADACLAP00001234; CADACLAG00001253.
    GeneIDi4706489.
    KEGGiact:ACLA_012130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027049 Genomic DNA. Translation: EAW12785.1 .
    RefSeqi XP_001274211.1. XM_001274210.1.

    3D structure databases

    ProteinModelPortali A1CAL7.
    SMRi A1CAL7. Positions 234-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00001234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00001253 ; CADACLAP00001234 ; CADACLAG00001253 .
    GeneIDi 4706489.
    KEGGi act:ACLA_012130.

    Phylogenomic databases

    HOGENOMi HOG000174182.
    KOi K11246.
    OMAi GSDTIQT.
    OrthoDBi EOG7MPRR4.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiSHO1_ASPCL
    AccessioniPrimary (citable) accession number: A1CAL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3