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Protein

High osmolarity signaling protein sho1

Gene

sho1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.By similarity

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
High osmolarity signaling protein sho1
Alternative name(s):
Osmosensor sho1
Gene namesi
Name:sho1
ORF Names:ACLA_012130
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_012130.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 46ExtracellularSequence analysisAdd BLAST11
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 69CytoplasmicSequence analysis2
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 104ExtracellularSequence analysisAdd BLAST14
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 292CytoplasmicSequence analysisAdd BLAST167

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004103581 – 292High osmolarity signaling protein sho1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Forms homooligomers.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00001234.

Structurei

3D structure databases

ProteinModelPortaliA1CAL7.
SMRiA1CAL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 292SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the SHO1 family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000174182.
KOiK11246.
OMAiWFAIFLQ.
OrthoDBiEOG092C3BG5.

Family and domain databases

CDDicd11855. SH3_Sho1p. 1 hit.
InterProiView protein in InterPro
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
IPR035522. Sho1_SH3.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CAL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFRASNIL GDPFALATIS IAILAWIIAF ISSIIANIKM ADYPNHAWWA
60 70 80 90 100
IAYMFCCTIG VTVVVGSDTG LVYGVAVVGY LSAGLVLTSL SVNTLVYKGN
110 120 130 140 150
SSAQAAAAGF ILLSMIIIVW IFYFGSTPQA THRGFIDSFA LNKEGGNAYG
160 170 180 190 200
NGRPISTAFG HRPETTSTSA PQMYTSAQLN GFETSSPISG YPGGAPGSEN
210 220 230 240 250
RSSSQPRFGN PSASNLPANN NGQSQDEVPQ PTEYPYRAKA IYSYDANPED
260 270 280 290
ANEISFSKHE ILEVSDVSGR WWQARKSSGE TGIAPSNYLI LL
Length:292
Mass (Da):31,192
Last modified:January 23, 2007 - v1
Checksum:iAD1484F9079AD04A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027049 Genomic DNA. Translation: EAW12785.1.
RefSeqiXP_001274211.1. XM_001274210.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001253; CADACLAP00001234; CADACLAG00001253.
GeneIDi4706489.
KEGGiact:ACLA_012130.

Similar proteinsi

Entry informationi

Entry nameiSHO1_ASPCL
AccessioniPrimary (citable) accession number: A1CAL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families