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A1CAI0

- BTGC_ASPCL

UniProt

A1CAI0 - BTGC_ASPCL

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Protein

Probable glucan endo-1,3-beta-glucosidase btgC

Gene

btgC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan (By similarity).By similarity

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei597 – 5971NucleophileBy similarity
Active sitei665 – 6651Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan endo-1,3-beta-glucosidase btgC (EC:3.2.1.39)
Alternative name(s):
Endo-1,3-beta-glucanase btgC
Laminarinase btgC
Gene namesi
Name:btgC
ORF Names:ACLA_011750
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Probable glucan endo-1,3-beta-glucosidase btgCPRO_0000395121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi642 – 6421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1CAI0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 317317CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini339 – 695357ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei318 – 33821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 35390Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000173877.
OMAiWLGVWQD.
OrthoDBiEOG7P8PHC.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00332. Glyco_hydro_17. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CAI0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSGPHRTFSF EQRGDGEAHS SFMDHAMHPQ YDDVSPISNM SSSPGHMNET
60 70 80 90 100
HHGLASVPED NHQGWGQARG PSPSNRTGFT ATPEMDNLGP ASVGGGISGI
110 120 130 140 150
ALGVANSHDR LSGVEARRGT DGQEANIPAE RGYNTTGSDN PYIPAPPDMG
160 170 180 190 200
GYGSSETLHP RQSYGSNVAL GAAAGPAGQL TPGHSATHLG TSNSSQRNLY
210 220 230 240 250
DAPYQSAGGL SAGPYQRHSA YSSNDLPLDI NPEEIADDGD DGFAPAGNSR
260 270 280 290 300
SSARRSQAVP AAAGGAAAGG VLGGIGGLFN NRNPAETSYD PVPGAGLEAG
310 320 330 340 350
EKSQWVKPKP STGSRKRGWI IGAILAVIII GAIVGGAVGG TIGHKDSGDS
360 370 380 390 400
ASGSSASTQS ASGDTDTNGD LDKNSAEIKA LMNNKDLHKV FPGMDYTPWG
410 420 430 440 450
VQYPLCLKYP PSQNNVTRDM AVLAQLTNNV RLYGTDCNQT EMVLHAIDKL
460 470 480 490 500
DLKDMKVWLG VWIDTNETTS RRQIDQLYKI VDDAKDISIF NGAIVGNEAL
510 520 530 540 550
FRAGDNKITA QATLTKYMQE VRDHFKKHDI KMPIATSDLG DNWNAELVQI
560 570 580 590 600
ADVVMSNVHP FFGGIPVDQA AAWTWRFWQD HDVILTQGTD KRQVISEVGW
610 620 630 640 650
PSGGGNDCGK GANCPDDTSG AVAGIDELNK FMEDWVCQAL DNGTDYFWFE
660 670 680 690
AFDEPWKIEF NTKNENWEDK WGLMDPARKL KSGLKIPDCG GKTAA
Length:695
Mass (Da):74,031
Last modified:January 23, 2007 - v1
Checksum:iFD2BC27323310650
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW12748.1.
RefSeqiXP_001274174.1. XM_001274173.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001237; CADACLAP00001218; CADACLAG00001237.
GeneIDi4706510.
KEGGiact:ACLA_011750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027049 Genomic DNA. Translation: EAW12748.1 .
RefSeqi XP_001274174.1. XM_001274173.1.

3D structure databases

ProteinModelPortali A1CAI0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00001237 ; CADACLAP00001218 ; CADACLAG00001237 .
GeneIDi 4706510.
KEGGi act:ACLA_011750.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000173877.
OMAi WLGVWQD.
OrthoDBi EOG7P8PHC.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00332. Glyco_hydro_17. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBTGC_ASPCL
AccessioniPrimary (citable) accession number: A1CAI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3