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A1CAI0

- BTGC_ASPCL

UniProt

A1CAI0 - BTGC_ASPCL

Protein

Probable glucan endo-1,3-beta-glucosidase btgC

Gene

btgC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei597 – 5971NucleophileBy similarity
    Active sitei665 – 6651Proton donorBy similarity

    GO - Molecular functioni

    1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucan endo-1,3-beta-glucosidase btgC (EC:3.2.1.39)
    Alternative name(s):
    Endo-1,3-beta-glucanase btgC
    Laminarinase btgC
    Gene namesi
    Name:btgC
    ORF Names:ACLA_011750
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Probable glucan endo-1,3-beta-glucosidase btgCPRO_0000395121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi642 – 6421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA1CAI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 317317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini339 – 695357ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei318 – 33821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi264 – 35390Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 17 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5309.
    HOGENOMiHOG000173877.
    OMAiWLGVWQD.
    OrthoDBiEOG7P8PHC.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR000490. Glyco_hydro_17.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00332. Glyco_hydro_17. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1CAI0-1 [UniParc]FASTAAdd to Basket

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    MSGPHRTFSF EQRGDGEAHS SFMDHAMHPQ YDDVSPISNM SSSPGHMNET    50
    HHGLASVPED NHQGWGQARG PSPSNRTGFT ATPEMDNLGP ASVGGGISGI 100
    ALGVANSHDR LSGVEARRGT DGQEANIPAE RGYNTTGSDN PYIPAPPDMG 150
    GYGSSETLHP RQSYGSNVAL GAAAGPAGQL TPGHSATHLG TSNSSQRNLY 200
    DAPYQSAGGL SAGPYQRHSA YSSNDLPLDI NPEEIADDGD DGFAPAGNSR 250
    SSARRSQAVP AAAGGAAAGG VLGGIGGLFN NRNPAETSYD PVPGAGLEAG 300
    EKSQWVKPKP STGSRKRGWI IGAILAVIII GAIVGGAVGG TIGHKDSGDS 350
    ASGSSASTQS ASGDTDTNGD LDKNSAEIKA LMNNKDLHKV FPGMDYTPWG 400
    VQYPLCLKYP PSQNNVTRDM AVLAQLTNNV RLYGTDCNQT EMVLHAIDKL 450
    DLKDMKVWLG VWIDTNETTS RRQIDQLYKI VDDAKDISIF NGAIVGNEAL 500
    FRAGDNKITA QATLTKYMQE VRDHFKKHDI KMPIATSDLG DNWNAELVQI 550
    ADVVMSNVHP FFGGIPVDQA AAWTWRFWQD HDVILTQGTD KRQVISEVGW 600
    PSGGGNDCGK GANCPDDTSG AVAGIDELNK FMEDWVCQAL DNGTDYFWFE 650
    AFDEPWKIEF NTKNENWEDK WGLMDPARKL KSGLKIPDCG GKTAA 695
    Length:695
    Mass (Da):74,031
    Last modified:January 23, 2007 - v1
    Checksum:iFD2BC27323310650
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027049 Genomic DNA. Translation: EAW12748.1.
    RefSeqiXP_001274174.1. XM_001274173.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00001237; CADACLAP00001218; CADACLAG00001237.
    GeneIDi4706510.
    KEGGiact:ACLA_011750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027049 Genomic DNA. Translation: EAW12748.1 .
    RefSeqi XP_001274174.1. XM_001274173.1.

    3D structure databases

    ProteinModelPortali A1CAI0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00001237 ; CADACLAP00001218 ; CADACLAG00001237 .
    GeneIDi 4706510.
    KEGGi act:ACLA_011750.

    Phylogenomic databases

    eggNOGi COG5309.
    HOGENOMi HOG000173877.
    OMAi WLGVWQD.
    OrthoDBi EOG7P8PHC.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR000490. Glyco_hydro_17.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00332. Glyco_hydro_17. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiBTGC_ASPCL
    AccessioniPrimary (citable) accession number: A1CAI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3