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A1CAF0 (MPKC_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase mpkC

Short name=MAP kinase C
EC=2.7.11.24
Gene names
Name:mpkC
ORF Names:ACLA_011450
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Mitogen-activated protein kinase mpkC
PRO_0000289712

Regions

Domain20 – 300281Protein kinase
Nucleotide binding26 – 349ATP By similarity
Motif171 – 1733TXY

Sites

Active site1411Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue1711Phosphothreonine By similarity
Modified residue1731Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1CAF0 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: C573DA3325CFD6CD

FASTA38043,486
        10         20         30         40         50         60 
MAEFVRAEIL GTKFEYTTRY VNLQPIGMGS FGLVCSAFDQ ITQQLVALKK VMKPFDGSSL 

        70         80         90        100        110        120 
AKRTYREIKL LKYLRHENLI CLRDIFISPL EDIYIATELL GTDLSRLLSV KPLDSQFAQY 

       130        140        150        160        170        180 
FIYQILRGLK YIHSANVIHR DLKPTNILIN ENCDLKICDF GLARLQEPQM TGYVSTRYYR 

       190        200        210        220        230        240 
APEIMLTWQR YGVQVDIWSA GCILAEMLRG KPLFPGKDHV HQFHLITNIL GNPPKSVLEK 

       250        260        270        280        290        300 
ITSKNTMKFV QSLPSREPRD LSTIVPKDTD FDAIDLLKKM LVIDPDIRVS AQDALRHPYL 

       310        320        330        340        350        360 
APYHDPTDEP VAAGPFDWSF NNMDLPKETW KVMIYSEVLD YLSVDSPDSG SMALGGSSPF 

       370        380 
DHRALDREFS EFFDDREGPM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027049 Genomic DNA. Translation: EAW12718.1.
RefSeqXP_001274144.1. XM_001274143.1.

3D structure databases

ProteinModelPortalA1CAF0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00000884.

Proteomic databases

PRIDEA1CAF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00000903; CADACLAP00000884; CADACLAG00000903.
GeneID4706955.
KEGGact:ACLA_011450.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OMAALPYDQT.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPKC_ASPCL
AccessionPrimary (citable) accession number: A1CAF0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families