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Protein

Mitogen-activated protein kinase mpkC

Gene

mpkC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1
Active sitei141Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
Short name:
MAP kinase C
Gene namesi
Name:mpkC
ORF Names:ACLA_011450
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_011450

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002897121 – 380Mitogen-activated protein kinase mpkCAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphothreonineBy similarity1
Modified residuei173PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA1CAF0

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00000884

Structurei

3D structure databases

ProteinModelPortaliA1CAF0
SMRiA1CAF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 300Protein kinasePROSITE-ProRule annotationAdd BLAST281

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 173TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233024
KOiK04441
OMAiRVQEPQM
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A1CAF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFVRAEIL GTKFEYTTRY VNLQPIGMGS FGLVCSAFDQ ITQQLVALKK
60 70 80 90 100
VMKPFDGSSL AKRTYREIKL LKYLRHENLI CLRDIFISPL EDIYIATELL
110 120 130 140 150
GTDLSRLLSV KPLDSQFAQY FIYQILRGLK YIHSANVIHR DLKPTNILIN
160 170 180 190 200
ENCDLKICDF GLARLQEPQM TGYVSTRYYR APEIMLTWQR YGVQVDIWSA
210 220 230 240 250
GCILAEMLRG KPLFPGKDHV HQFHLITNIL GNPPKSVLEK ITSKNTMKFV
260 270 280 290 300
QSLPSREPRD LSTIVPKDTD FDAIDLLKKM LVIDPDIRVS AQDALRHPYL
310 320 330 340 350
APYHDPTDEP VAAGPFDWSF NNMDLPKETW KVMIYSEVLD YLSVDSPDSG
360 370 380
SMALGGSSPF DHRALDREFS EFFDDREGPM
Length:380
Mass (Da):43,486
Last modified:January 23, 2007 - v1
Checksum:iC573DA3325CFD6CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027049 Genomic DNA Translation: EAW12718.1
RefSeqiXP_001274144.1, XM_001274143.1

Genome annotation databases

EnsemblFungiiCADACLAT00000903; CADACLAP00000884; CADACLAG00000903
GeneIDi4706955
KEGGiact:ACLA_011450

Similar proteinsi

Entry informationi

Entry nameiMPKC_ASPCL
AccessioniPrimary (citable) accession number: A1CAF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health