Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1C9M6

- DCL2_ASPCL

UniProt

A1C9M6 - DCL2_ASPCL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dicer-like protein 2

Gene

dcl2

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.By similarity

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1138 – 11381Magnesium or manganeseBy similarity
Sitei1264 – 12641Important for activityBy similarity
Metal bindingi1268 – 12681Magnesium or manganeseBy similarity
Metal bindingi1271 – 12711Magnesium or manganeseBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. ribonuclease III activity Source: InterPro
  5. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. regulation of defense response to virus Source: UniProtKB-KW
  3. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 2
Including the following 2 domains:
Endoribonuclease dcl2 (EC:3.1.26.-)
ATP-dependent helicase dcl2 (EC:3.6.4.-)
Gene namesi
Name:dcl2
ORF Names:ACLA_055980
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13891389Dicer-like protein 2PRO_0000306785Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005115.

Structurei

3D structure databases

ProteinModelPortaliA1C9M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 203181Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini368 – 537170Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini564 – 65895Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd
BLAST
Domaini920 – 1060141RNase III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1099 – 1282184RNase III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi144 – 1474DEAH box

Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation
Contains 1 Dicer dsRNA-binding fold domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 2 RNase III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000048683.
OMAiCKTPRAH.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR005034. Dicer_dimerisation_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C9M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAVPTNSD AAAYQARNYQ LEMLEASMKE NIIVAMDTGS GKTHIAVLRI
60 70 80 90 100
KAELDSCPPD KIIWFLAPTV ALCTQQHKVI ASNLPAVQTR TLTGLDKVEL
110 120 130 140 150
WTEQAIWDAI LKDVRVVVST YAVLADALSH GFMRMSRLAL IIFDEAHHCM
160 170 180 190 200
RKHAANKIMQ DFYHPTVSKF GPSAVPRIMG LTASPVVRSN REELFTIETN
210 220 230 240 250
LDAVCKTPRA HRQELLKFSH RPELKQLLYE PPDPMGLQVS SQTLRALIEA
260 270 280 290 300
WETLDIEDDP YVKRLRKSSL DGGALEKALM TGKTFCREQL KRFVDRSRHI
310 320 330 340 350
FEELGEWAAD YYIYTSIQHL KTRVQTSYMT GDWDEAERAY LVSFLSKLPA
360 370 380 390 400
ADIQITLSDA ACLRISPKLE ALIGFLDAMD DPEFSGLIFV KQRATVSVMT
410 420 430 440 450
DLLAVHPRTR ERFRSAAYVG WSNSSGSKDF LGNLLSMHGQ LSTLDDFRSG
460 470 480 490 500
HKNLIIATDV LEEGIDISAC SVVVCYDKPP NLKSFVQRRG RARQKQSTYA
510 520 530 540 550
IMFPAEDSAF DLAKWQTLEQ AMIEAYQDDE RHLQSAIELE RVNEEVVERF
560 570 580 590 600
TVESTSAVLT ADTAMAHLHH FCAVLPSQPY VDMRPVFSVE TDIANLRRGI
610 620 630 640 650
VILPNCVHPK VRRSEGQRWW RTERAAMKEA AFQAYKSLYE FGLVNDNLLP
660 670 680 690 700
LTNKPELKVN KLGSIPSIME ASEQYDPWVD WAYSWSSPDI HQSRVVVRLN
710 720 730 740 750
GAKDRELCMR LAGPTVLPPL APMTLFWDSE TTFTVAFEAP ERVPHVPLSS
760 770 780 790 800
VEDMRTSTVV YLQATSSRLL STKQDFTALF GPDLPHTDLK AWLQMYEGNE
810 820 830 840 850
PAVEVYSRRR DPMLMGVVRD CSRYNEPLLF RRWVESGDSP TTSVVEMECD
860 870 880 890 900
PFPRRRNLLH RQTLATKKLE NDKEDTPEPV NKMRTVAADQ CTIDRLPFSN
910 920 930 940 950
AILGLFISVV VQQLETELIA TKLYETILRD VGFTSTQHII TAISAPSAQA
960 970 980 990 1000
LTNYQRYEFL GDSILKFSVS CQLFFKHPNW HEGYLSEGRD EIVQNPRLTK
1010 1020 1030 1040 1050
AALDTGLDAF VITKMFTPRK WSAPLISERL ERVAGKRQVS SKVLADVVEA
1060 1070 1080 1090 1100
LIGAAYMDGG HAAAQACIRR FLPEINLHSL DTRTLSRSVA PEGARQTIHD
1110 1120 1130 1140 1150
RLKRHISYTF ENESLLVEAL THPSCDYDAS TQSYQRLEFL GDAVLDMIIV
1160 1170 1180 1190 1200
SAIFNHPVQM PQGHMTKIKH ALVNANLLAF LCMEFAIPEE RASVEQISTL
1210 1220 1230 1240 1250
QFEVISNEEL VELWRFMRYR GLDLNNARDA SLARHRALRD EILHSLQHDP
1260 1270 1280 1290 1300
HYPWQALSRL SADKFFSDIM ESILGAIFVD SGGDLAPCEA FVERIGLMSY
1310 1320 1330 1340 1350
LRRILDENIE VTHPRNVAQQ LAKSNIQFLA QRMPDEEGGA SYQCAVRIEE
1360 1370 1380
VEAFVVRGCL TAEEAEVTAA IDAIDLLMER VNGSASVAS
Length:1,389
Mass (Da):156,806
Last modified:January 23, 2007 - v1
Checksum:iEA8AAF2FA35F7D55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027048 Genomic DNA. Translation: EAW13550.1.
RefSeqiXP_001274976.1. XM_001274975.1.

Genome annotation databases

EnsemblFungiiCADACLAT00005226; CADACLAP00005115; CADACLAG00005226.
GeneIDi4707091.
KEGGiact:ACLA_055980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027048 Genomic DNA. Translation: EAW13550.1 .
RefSeqi XP_001274976.1. XM_001274975.1.

3D structure databases

ProteinModelPortali A1C9M6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00005226 ; CADACLAP00005115 ; CADACLAG00005226 .
GeneIDi 4707091.
KEGGi act:ACLA_055980.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000048683.
OMAi CKTPRAH.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR005034. Dicer_dimerisation_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDCL2_ASPCL
AccessioniPrimary (citable) accession number: A1C9M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3