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A1C9M6

- DCL2_ASPCL

UniProt

A1C9M6 - DCL2_ASPCL

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Protein
Dicer-like protein 2
Gene
dcl2, ACLA_055980
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1138 – 11381Magnesium or manganese By similarity
Sitei1264 – 12641Important for activity By similarity
Metal bindingi1268 – 12681Magnesium or manganese By similarity
Metal bindingi1271 – 12711Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. ribonuclease III activity Source: InterPro

GO - Biological processi

  1. RNA processing Source: InterPro
  2. defense response to virus Source: UniProtKB-KW
  3. regulation of defense response to virus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 2
Including the following 2 domains:
Endoribonuclease dcl2 (EC:3.1.26.-)
ATP-dependent helicase dcl2 (EC:3.6.4.-)
Gene namesi
Name:dcl2
ORF Names:ACLA_055980
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13891389Dicer-like protein 2
PRO_0000306785Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005115.

Structurei

3D structure databases

ProteinModelPortaliA1C9M6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 203181Helicase ATP-binding
Add
BLAST
Domaini368 – 537170Helicase C-terminal
Add
BLAST
Domaini564 – 65895Dicer dsRNA-binding fold
Add
BLAST
Domaini920 – 1060141RNase III 1
Add
BLAST
Domaini1099 – 1282184RNase III 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi144 – 1474DEAH box

Sequence similaritiesi

Contains 2 RNase III domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000048683.
OMAiCKTPRAH.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C9M6-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAVPTNSD AAAYQARNYQ LEMLEASMKE NIIVAMDTGS GKTHIAVLRI     50
KAELDSCPPD KIIWFLAPTV ALCTQQHKVI ASNLPAVQTR TLTGLDKVEL 100
WTEQAIWDAI LKDVRVVVST YAVLADALSH GFMRMSRLAL IIFDEAHHCM 150
RKHAANKIMQ DFYHPTVSKF GPSAVPRIMG LTASPVVRSN REELFTIETN 200
LDAVCKTPRA HRQELLKFSH RPELKQLLYE PPDPMGLQVS SQTLRALIEA 250
WETLDIEDDP YVKRLRKSSL DGGALEKALM TGKTFCREQL KRFVDRSRHI 300
FEELGEWAAD YYIYTSIQHL KTRVQTSYMT GDWDEAERAY LVSFLSKLPA 350
ADIQITLSDA ACLRISPKLE ALIGFLDAMD DPEFSGLIFV KQRATVSVMT 400
DLLAVHPRTR ERFRSAAYVG WSNSSGSKDF LGNLLSMHGQ LSTLDDFRSG 450
HKNLIIATDV LEEGIDISAC SVVVCYDKPP NLKSFVQRRG RARQKQSTYA 500
IMFPAEDSAF DLAKWQTLEQ AMIEAYQDDE RHLQSAIELE RVNEEVVERF 550
TVESTSAVLT ADTAMAHLHH FCAVLPSQPY VDMRPVFSVE TDIANLRRGI 600
VILPNCVHPK VRRSEGQRWW RTERAAMKEA AFQAYKSLYE FGLVNDNLLP 650
LTNKPELKVN KLGSIPSIME ASEQYDPWVD WAYSWSSPDI HQSRVVVRLN 700
GAKDRELCMR LAGPTVLPPL APMTLFWDSE TTFTVAFEAP ERVPHVPLSS 750
VEDMRTSTVV YLQATSSRLL STKQDFTALF GPDLPHTDLK AWLQMYEGNE 800
PAVEVYSRRR DPMLMGVVRD CSRYNEPLLF RRWVESGDSP TTSVVEMECD 850
PFPRRRNLLH RQTLATKKLE NDKEDTPEPV NKMRTVAADQ CTIDRLPFSN 900
AILGLFISVV VQQLETELIA TKLYETILRD VGFTSTQHII TAISAPSAQA 950
LTNYQRYEFL GDSILKFSVS CQLFFKHPNW HEGYLSEGRD EIVQNPRLTK 1000
AALDTGLDAF VITKMFTPRK WSAPLISERL ERVAGKRQVS SKVLADVVEA 1050
LIGAAYMDGG HAAAQACIRR FLPEINLHSL DTRTLSRSVA PEGARQTIHD 1100
RLKRHISYTF ENESLLVEAL THPSCDYDAS TQSYQRLEFL GDAVLDMIIV 1150
SAIFNHPVQM PQGHMTKIKH ALVNANLLAF LCMEFAIPEE RASVEQISTL 1200
QFEVISNEEL VELWRFMRYR GLDLNNARDA SLARHRALRD EILHSLQHDP 1250
HYPWQALSRL SADKFFSDIM ESILGAIFVD SGGDLAPCEA FVERIGLMSY 1300
LRRILDENIE VTHPRNVAQQ LAKSNIQFLA QRMPDEEGGA SYQCAVRIEE 1350
VEAFVVRGCL TAEEAEVTAA IDAIDLLMER VNGSASVAS 1389
Length:1,389
Mass (Da):156,806
Last modified:January 23, 2007 - v1
Checksum:iEA8AAF2FA35F7D55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027048 Genomic DNA. Translation: EAW13550.1.
RefSeqiXP_001274976.1. XM_001274975.1.

Genome annotation databases

EnsemblFungiiCADACLAT00005226; CADACLAP00005115; CADACLAG00005226.
GeneIDi4707091.
KEGGiact:ACLA_055980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027048 Genomic DNA. Translation: EAW13550.1 .
RefSeqi XP_001274976.1. XM_001274975.1.

3D structure databases

ProteinModelPortali A1C9M6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00005226 ; CADACLAP00005115 ; CADACLAG00005226 .
GeneIDi 4707091.
KEGGi act:ACLA_055980.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000048683.
OMAi CKTPRAH.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiDCL2_ASPCL
AccessioniPrimary (citable) accession number: A1C9M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi