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A1C9L6 (NTE1_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:ACLA_055880
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1528 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence EAW13540.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15281528Lysophospholipase nte1
PRO_0000295309

Regions

Topological domain1 – 7272Cytoplasmic By similarity
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 11522Lumenal By similarity
Transmembrane116 – 13621Helical; Potential
Topological domain137 – 15281392Cytoplasmic By similarity
Domain1225 – 1389165Patatin
Nucleotide binding686 – 805120cNMP 1
Nucleotide binding846 – 966121cNMP 2
Motif1256 – 12605GXSXG
Compositional bias21 – 3313Poly-Ser
Compositional bias59 – 646Poly-Pro
Compositional bias298 – 30710Poly-Ser

Sites

Active site12581 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1C9L6 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: D5982DE223A05DD9

FASTA1,528168,937
        10         20         30         40         50         60 
MADGNLLGSS TSLTALLPTP SSASLSASLS SSSLPVSPFL APAPTTAITA SIASLSAQPP 

        70         80         90        100        110        120 
PPLPATPATM AGWIGWVFSF FFQFIPSVLY SVITFTTITL PTWLFTLFSM SLTFTMNFTT 

       130        140        150        160        170        180 
LLLILLAVVS TLGWFVRYRF LNMYSRLPPE PQRKEPQIDL FPDVQGGDSK PGLANYLDEF 

       190        200        210        220        230        240 
LSAIKVFGYL ERPVFHELTR TMQTRKLIAG ETLMLEEEKG FCLVVDGLVQ IFVKSTRDGK 

       250        260        270        280        290        300 
SGSDDELHHL GAESSDEEHH IDGKQGYQLL TEVKNGASMS SLFSILSLFT EDIQVWDSQS 

       310        320        330        340        350        360 
STSSSSSIAM RAARVPDSTP NSPRGGMDSP TPIFRDVPDP VSLVNENGDL PLVPPLHLEE 

       370        380        390        400        410        420 
SPIPPTNHAH DRRQHDHRKH HGRKHRKSVH PDIVARAMVD TTIAIIPASA FRRLTRVYPR 

       430        440        450        460        470        480 
ATAHIVQVIL TRLQRVTFAT AHSYLGLSNE VLGIEKQMTK FTTYDLPNNM RGTALDRLKD 

       490        500        510        520        530        540 
KFIKERDRLG TEEVTKGIAL HNPSAGRRRR SSSFMRKDAV LHAKMMSPKR AATVITSDNS 

       550        560        570        580        590        600 
YDHDSAGVSP GDLLSTIQQS RFGPRYEQPT PRLRSPLAEK ENSHFRLPAM QARNAFHRKE 

       610        620        630        640        650        660 
SLDEDALFRE CILDCIMKAI GLTSSTGEVL RKSSHSGEAS PKLLSYDSRR QKAVFSNNAF 

       670        680        690        700        710        720 
GFIDPYEGSG DGETESMMSM SVTSAGGTSP VTSLREELRN DIEIVYFPQG SVLVEQGERH 

       730        740        750        760        770        780 
PGLYYVIDGF LDVGMPVVDK GEDLVGVSKP ATAREPFPTL KRTTTASSIK PSATAANDPR 

       790        800        810        820        830        840 
RRKQSRKSLY LIKPGGIQGY VGAVASYRSY TDVVAKTDVY VGFLPRASLE RIAERYPIAL 

       850        860        870        880        890        900 
LTLAKRLTSL LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLESADN 

       910        920        930        940        950        960 
KLTVIGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ EHPGITIQVS 

       970        980        990       1000       1010       1020 
KLIAQRMRDL VERPVTEKGA ERSSAGGVQT ATSTLNLRTV GILPVTAGVP VVEFGNRLLH 

      1030       1040       1050       1060       1070       1080 
ALHQIGVVNG VTSLNQSAIL NHLGRHAFSK MGKLKLAQYL ADLEEKYGMV LYIADTNVNS 

      1090       1100       1110       1120       1130       1140 
PWTQTCITQA DCILLVGLAE SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRRW 

      1150       1160       1170       1180       1190       1200 
LKNRVWINGG HHHIQMAFRL TAEPSHPETK RFGTVLKQRV QVLQAEIQKY TSRRIRQTPL 

      1210       1220       1230       1240       1250       1260 
YSAQTPFKGD FHRLARRLCG RAVGLVLGGG GARGIAHVGV IKALEEAGIP VDIIGGTSIG 

      1270       1280       1290       1300       1310       1320 
SFIGALYARD ADVVPMYGRA KKFAGRMGSM WRFALDLTYP TISYTTGHEF NRGIFKTFGD 

      1330       1340       1350       1360       1370       1380 
SQIEDFWLEF YCNTTNISKS RQEYHSSGYV WRYVRASMSL AGLIPPICDE GSMLLDGGYI 

      1390       1400       1410       1420       1430       1440 
DNLTVDHMKG LGADVIFAVD VGSIDDNTPQ GYGDSLSGFW VAFNRWNPFS SCPNPPTLSE 

      1450       1460       1470       1480       1490       1500 
IQARLAYVSS IDNLERAKIT PGCLYMRPPI DAYGTLEFGK FDEIYQVGYK FGKQFLEKLK 

      1510       1520 
NEGSLPLPEE TEEEKKLLRT MAPRRASI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027048 Genomic DNA. Translation: EAW13540.1. Different initiation.
RefSeqXP_001274966.1. XM_001274965.1.

3D structure databases

ProteinModelPortalA1C9L6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00005041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4707103.
KEGGact:ACLA_055880.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_ASPCL
AccessionPrimary (citable) accession number: A1C9L6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families