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A1C9L6

- NTE1_ASPCL

UniProt

A1C9L6 - NTE1_ASPCL

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Protein
Lysophospholipase nte1
Gene
nte1, ACLA_055880
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1258 – 12581 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi686 – 805120cNMP 1
Add
BLAST
Nucleotide bindingi846 – 966121cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:ACLA_055880
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272Cytoplasmic By similarity
Add
BLAST
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Topological domaini94 – 11522Lumenal By similarity
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Topological domaini137 – 15281392Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15281528Lysophospholipase nte1
PRO_0000295309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005041.

Structurei

3D structure databases

ProteinModelPortaliA1C9L6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1225 – 1389165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1256 – 12605GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 3313Poly-Ser
Add
BLAST
Compositional biasi59 – 646Poly-Pro
Compositional biasi298 – 30710Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C9L6-1 [UniParc]FASTAAdd to Basket

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MADGNLLGSS TSLTALLPTP SSASLSASLS SSSLPVSPFL APAPTTAITA     50
SIASLSAQPP PPLPATPATM AGWIGWVFSF FFQFIPSVLY SVITFTTITL 100
PTWLFTLFSM SLTFTMNFTT LLLILLAVVS TLGWFVRYRF LNMYSRLPPE 150
PQRKEPQIDL FPDVQGGDSK PGLANYLDEF LSAIKVFGYL ERPVFHELTR 200
TMQTRKLIAG ETLMLEEEKG FCLVVDGLVQ IFVKSTRDGK SGSDDELHHL 250
GAESSDEEHH IDGKQGYQLL TEVKNGASMS SLFSILSLFT EDIQVWDSQS 300
STSSSSSIAM RAARVPDSTP NSPRGGMDSP TPIFRDVPDP VSLVNENGDL 350
PLVPPLHLEE SPIPPTNHAH DRRQHDHRKH HGRKHRKSVH PDIVARAMVD 400
TTIAIIPASA FRRLTRVYPR ATAHIVQVIL TRLQRVTFAT AHSYLGLSNE 450
VLGIEKQMTK FTTYDLPNNM RGTALDRLKD KFIKERDRLG TEEVTKGIAL 500
HNPSAGRRRR SSSFMRKDAV LHAKMMSPKR AATVITSDNS YDHDSAGVSP 550
GDLLSTIQQS RFGPRYEQPT PRLRSPLAEK ENSHFRLPAM QARNAFHRKE 600
SLDEDALFRE CILDCIMKAI GLTSSTGEVL RKSSHSGEAS PKLLSYDSRR 650
QKAVFSNNAF GFIDPYEGSG DGETESMMSM SVTSAGGTSP VTSLREELRN 700
DIEIVYFPQG SVLVEQGERH PGLYYVIDGF LDVGMPVVDK GEDLVGVSKP 750
ATAREPFPTL KRTTTASSIK PSATAANDPR RRKQSRKSLY LIKPGGIQGY 800
VGAVASYRSY TDVVAKTDVY VGFLPRASLE RIAERYPIAL LTLAKRLTSL 850
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLESADN 900
KLTVIGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 950
EHPGITIQVS KLIAQRMRDL VERPVTEKGA ERSSAGGVQT ATSTLNLRTV 1000
GILPVTAGVP VVEFGNRLLH ALHQIGVVNG VTSLNQSAIL NHLGRHAFSK 1050
MGKLKLAQYL ADLEEKYGMV LYIADTNVNS PWTQTCITQA DCILLVGLAE 1100
SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRRW LKNRVWINGG 1150
HHHIQMAFRL TAEPSHPETK RFGTVLKQRV QVLQAEIQKY TSRRIRQTPL 1200
YSAQTPFKGD FHRLARRLCG RAVGLVLGGG GARGIAHVGV IKALEEAGIP 1250
VDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMGSM WRFALDLTYP 1300
TISYTTGHEF NRGIFKTFGD SQIEDFWLEF YCNTTNISKS RQEYHSSGYV 1350
WRYVRASMSL AGLIPPICDE GSMLLDGGYI DNLTVDHMKG LGADVIFAVD 1400
VGSIDDNTPQ GYGDSLSGFW VAFNRWNPFS SCPNPPTLSE IQARLAYVSS 1450
IDNLERAKIT PGCLYMRPPI DAYGTLEFGK FDEIYQVGYK FGKQFLEKLK 1500
NEGSLPLPEE TEEEKKLLRT MAPRRASI 1528
Length:1,528
Mass (Da):168,937
Last modified:July 24, 2007 - v2
Checksum:iD5982DE223A05DD9
GO

Sequence cautioni

The sequence EAW13540.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027048 Genomic DNA. Translation: EAW13540.1. Different initiation.
RefSeqiXP_001274966.1. XM_001274965.1.

Genome annotation databases

GeneIDi4707103.
KEGGiact:ACLA_055880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027048 Genomic DNA. Translation: EAW13540.1 . Different initiation.
RefSeqi XP_001274966.1. XM_001274965.1.

3D structure databases

ProteinModelPortali A1C9L6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4707103.
KEGGi act:ACLA_055880.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiNTE1_ASPCL
AccessioniPrimary (citable) accession number: A1C9L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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