Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1C9L6

- NTE1_ASPCL

UniProt

A1C9L6 - NTE1_ASPCL

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1258 – 12581By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi686 – 805120cNMP 1Add
    BLAST
    Nucleotide bindingi846 – 966121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:ACLA_055880
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15281528Lysophospholipase nte1PRO_0000295309Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00005041.

    Structurei

    3D structure databases

    ProteinModelPortaliA1C9L6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7272CytoplasmicBy similarityAdd
    BLAST
    Topological domaini94 – 11522LumenalBy similarityAdd
    BLAST
    Topological domaini137 – 15281392CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1225 – 1389165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1256 – 12605GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 3313Poly-SerAdd
    BLAST
    Compositional biasi59 – 646Poly-Pro
    Compositional biasi298 – 30710Poly-Ser

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1C9L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADGNLLGSS TSLTALLPTP SSASLSASLS SSSLPVSPFL APAPTTAITA     50
    SIASLSAQPP PPLPATPATM AGWIGWVFSF FFQFIPSVLY SVITFTTITL 100
    PTWLFTLFSM SLTFTMNFTT LLLILLAVVS TLGWFVRYRF LNMYSRLPPE 150
    PQRKEPQIDL FPDVQGGDSK PGLANYLDEF LSAIKVFGYL ERPVFHELTR 200
    TMQTRKLIAG ETLMLEEEKG FCLVVDGLVQ IFVKSTRDGK SGSDDELHHL 250
    GAESSDEEHH IDGKQGYQLL TEVKNGASMS SLFSILSLFT EDIQVWDSQS 300
    STSSSSSIAM RAARVPDSTP NSPRGGMDSP TPIFRDVPDP VSLVNENGDL 350
    PLVPPLHLEE SPIPPTNHAH DRRQHDHRKH HGRKHRKSVH PDIVARAMVD 400
    TTIAIIPASA FRRLTRVYPR ATAHIVQVIL TRLQRVTFAT AHSYLGLSNE 450
    VLGIEKQMTK FTTYDLPNNM RGTALDRLKD KFIKERDRLG TEEVTKGIAL 500
    HNPSAGRRRR SSSFMRKDAV LHAKMMSPKR AATVITSDNS YDHDSAGVSP 550
    GDLLSTIQQS RFGPRYEQPT PRLRSPLAEK ENSHFRLPAM QARNAFHRKE 600
    SLDEDALFRE CILDCIMKAI GLTSSTGEVL RKSSHSGEAS PKLLSYDSRR 650
    QKAVFSNNAF GFIDPYEGSG DGETESMMSM SVTSAGGTSP VTSLREELRN 700
    DIEIVYFPQG SVLVEQGERH PGLYYVIDGF LDVGMPVVDK GEDLVGVSKP 750
    ATAREPFPTL KRTTTASSIK PSATAANDPR RRKQSRKSLY LIKPGGIQGY 800
    VGAVASYRSY TDVVAKTDVY VGFLPRASLE RIAERYPIAL LTLAKRLTSL 850
    LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLESADN 900
    KLTVIGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 950
    EHPGITIQVS KLIAQRMRDL VERPVTEKGA ERSSAGGVQT ATSTLNLRTV 1000
    GILPVTAGVP VVEFGNRLLH ALHQIGVVNG VTSLNQSAIL NHLGRHAFSK 1050
    MGKLKLAQYL ADLEEKYGMV LYIADTNVNS PWTQTCITQA DCILLVGLAE 1100
    SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRRW LKNRVWINGG 1150
    HHHIQMAFRL TAEPSHPETK RFGTVLKQRV QVLQAEIQKY TSRRIRQTPL 1200
    YSAQTPFKGD FHRLARRLCG RAVGLVLGGG GARGIAHVGV IKALEEAGIP 1250
    VDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMGSM WRFALDLTYP 1300
    TISYTTGHEF NRGIFKTFGD SQIEDFWLEF YCNTTNISKS RQEYHSSGYV 1350
    WRYVRASMSL AGLIPPICDE GSMLLDGGYI DNLTVDHMKG LGADVIFAVD 1400
    VGSIDDNTPQ GYGDSLSGFW VAFNRWNPFS SCPNPPTLSE IQARLAYVSS 1450
    IDNLERAKIT PGCLYMRPPI DAYGTLEFGK FDEIYQVGYK FGKQFLEKLK 1500
    NEGSLPLPEE TEEEKKLLRT MAPRRASI 1528
    Length:1,528
    Mass (Da):168,937
    Last modified:July 24, 2007 - v2
    Checksum:iD5982DE223A05DD9
    GO

    Sequence cautioni

    The sequence EAW13540.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027048 Genomic DNA. Translation: EAW13540.1. Different initiation.
    RefSeqiXP_001274966.1. XM_001274965.1.

    Genome annotation databases

    GeneIDi4707103.
    KEGGiact:ACLA_055880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027048 Genomic DNA. Translation: EAW13540.1 . Different initiation.
    RefSeqi XP_001274966.1. XM_001274965.1.

    3D structure databases

    ProteinModelPortali A1C9L6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00005041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4707103.
    KEGGi act:ACLA_055880.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiNTE1_ASPCL
    AccessioniPrimary (citable) accession number: A1C9L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3