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A1C9L6

- NTE1_ASPCL

UniProt

A1C9L6 - NTE1_ASPCL

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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1258 – 12581By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi686 – 805120cNMP 1Add
BLAST
Nucleotide bindingi846 – 966121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:ACLA_055880
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272CytoplasmicBy similarityAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Topological domaini94 – 11522LumenalBy similarityAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 15281392CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15281528Lysophospholipase nte1PRO_0000295309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005041.

Structurei

3D structure databases

ProteinModelPortaliA1C9L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1225 – 1389165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1256 – 12605GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 3313Poly-SerAdd
BLAST
Compositional biasi59 – 646Poly-Pro
Compositional biasi298 – 30710Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C9L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGNLLGSS TSLTALLPTP SSASLSASLS SSSLPVSPFL APAPTTAITA
60 70 80 90 100
SIASLSAQPP PPLPATPATM AGWIGWVFSF FFQFIPSVLY SVITFTTITL
110 120 130 140 150
PTWLFTLFSM SLTFTMNFTT LLLILLAVVS TLGWFVRYRF LNMYSRLPPE
160 170 180 190 200
PQRKEPQIDL FPDVQGGDSK PGLANYLDEF LSAIKVFGYL ERPVFHELTR
210 220 230 240 250
TMQTRKLIAG ETLMLEEEKG FCLVVDGLVQ IFVKSTRDGK SGSDDELHHL
260 270 280 290 300
GAESSDEEHH IDGKQGYQLL TEVKNGASMS SLFSILSLFT EDIQVWDSQS
310 320 330 340 350
STSSSSSIAM RAARVPDSTP NSPRGGMDSP TPIFRDVPDP VSLVNENGDL
360 370 380 390 400
PLVPPLHLEE SPIPPTNHAH DRRQHDHRKH HGRKHRKSVH PDIVARAMVD
410 420 430 440 450
TTIAIIPASA FRRLTRVYPR ATAHIVQVIL TRLQRVTFAT AHSYLGLSNE
460 470 480 490 500
VLGIEKQMTK FTTYDLPNNM RGTALDRLKD KFIKERDRLG TEEVTKGIAL
510 520 530 540 550
HNPSAGRRRR SSSFMRKDAV LHAKMMSPKR AATVITSDNS YDHDSAGVSP
560 570 580 590 600
GDLLSTIQQS RFGPRYEQPT PRLRSPLAEK ENSHFRLPAM QARNAFHRKE
610 620 630 640 650
SLDEDALFRE CILDCIMKAI GLTSSTGEVL RKSSHSGEAS PKLLSYDSRR
660 670 680 690 700
QKAVFSNNAF GFIDPYEGSG DGETESMMSM SVTSAGGTSP VTSLREELRN
710 720 730 740 750
DIEIVYFPQG SVLVEQGERH PGLYYVIDGF LDVGMPVVDK GEDLVGVSKP
760 770 780 790 800
ATAREPFPTL KRTTTASSIK PSATAANDPR RRKQSRKSLY LIKPGGIQGY
810 820 830 840 850
VGAVASYRSY TDVVAKTDVY VGFLPRASLE RIAERYPIAL LTLAKRLTSL
860 870 880 890 900
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLESADN
910 920 930 940 950
KLTVIGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ
960 970 980 990 1000
EHPGITIQVS KLIAQRMRDL VERPVTEKGA ERSSAGGVQT ATSTLNLRTV
1010 1020 1030 1040 1050
GILPVTAGVP VVEFGNRLLH ALHQIGVVNG VTSLNQSAIL NHLGRHAFSK
1060 1070 1080 1090 1100
MGKLKLAQYL ADLEEKYGMV LYIADTNVNS PWTQTCITQA DCILLVGLAE
1110 1120 1130 1140 1150
SSPSIGEYER FLLGMKTTAR KELVLLHSER YCPPGLTRRW LKNRVWINGG
1160 1170 1180 1190 1200
HHHIQMAFRL TAEPSHPETK RFGTVLKQRV QVLQAEIQKY TSRRIRQTPL
1210 1220 1230 1240 1250
YSAQTPFKGD FHRLARRLCG RAVGLVLGGG GARGIAHVGV IKALEEAGIP
1260 1270 1280 1290 1300
VDIIGGTSIG SFIGALYARD ADVVPMYGRA KKFAGRMGSM WRFALDLTYP
1310 1320 1330 1340 1350
TISYTTGHEF NRGIFKTFGD SQIEDFWLEF YCNTTNISKS RQEYHSSGYV
1360 1370 1380 1390 1400
WRYVRASMSL AGLIPPICDE GSMLLDGGYI DNLTVDHMKG LGADVIFAVD
1410 1420 1430 1440 1450
VGSIDDNTPQ GYGDSLSGFW VAFNRWNPFS SCPNPPTLSE IQARLAYVSS
1460 1470 1480 1490 1500
IDNLERAKIT PGCLYMRPPI DAYGTLEFGK FDEIYQVGYK FGKQFLEKLK
1510 1520
NEGSLPLPEE TEEEKKLLRT MAPRRASI
Length:1,528
Mass (Da):168,937
Last modified:July 24, 2007 - v2
Checksum:iD5982DE223A05DD9
GO

Sequence cautioni

The sequence EAW13540.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027048 Genomic DNA. Translation: EAW13540.1. Different initiation.
RefSeqiXP_001274966.1. XM_001274965.1.

Genome annotation databases

GeneIDi4707103.
KEGGiact:ACLA_055880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027048 Genomic DNA. Translation: EAW13540.1 . Different initiation.
RefSeqi XP_001274966.1. XM_001274965.1.

3D structure databases

ProteinModelPortali A1C9L6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4707103.
KEGGi act:ACLA_055880.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiNTE1_ASPCL
AccessioniPrimary (citable) accession number: A1C9L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3