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Protein

Catalase-peroxidase

Gene

katG

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei93 – 931Transition state stabilizerUniRule annotation
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi283 – 2831Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:ACLA_044200
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_044200.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Catalase-peroxidasePRO_0000354098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki96 ↔ 242Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-268)UniRule annotation
Cross-linki242 ↔ 268Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1C8R3.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1C8R3.
SMRiA1C8R3. Positions 21-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C8R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESKCPFKS QGSRSNVAGG GTRNTDWWPE QLKLNILRQH TTVTNPLGAD
60 70 80 90 100
FDYAAAFNTL DYDALKKDLT ALMTDSQEWW PADFGHYGGL FIRMAWHSAG
110 120 130 140 150
TYRVFDGRGG AGQGQQRFAP LNSWPDNVSL DKARRLLWPI KQKYGDKISW
160 170 180 190 200
ADLMILTGNV ALESMGFKTF GFAGGRADTW EADESAYWGR ETTWLGNDAR
210 220 230 240 250
YEKGFSGSDK QGTVIADEAS HKTTHSRELE NPLAAAHMGL IYVNPEGPDG
260 270 280 290 300
NPDPVAAAHD IRVTFGRMAM NDEETVALIA GGHTFGKTHG AAPADNVGKE
310 320 330 340 350
PEAAGLEAQG LGWQNSHGSG KGPDTITSGL EVTWTKTPTK WSNQFLEYLF
360 370 380 390 400
KFDWELTKSP AGAHQWVAKN ADDIIPDAYD AFKKHKPTML TTDLSLRFDP
410 420 430 440 450
AYEKISRRFL ENPDQFADAF ARAWFKLTHR DMGPRARYLG PEVPGEVLLW
460 470 480 490 500
QDPIPAVNHA LIDTVDTAAL KRDVLATGVN PSKFISTAWA AASTFRGSDK
510 520 530 540 550
RGGANGARIR FAPQRSWEVN NQPWLQESLS ALEGVQSRFN ASRPDRKQVS
560 570 580 590 600
LADLIVLAGC AAVEQAAHDA GFPVRVPFTP GRMDASQDET DVESFSHMEP
610 620 630 640 650
IADGFRNYAK PYVHGRAEHY LVDKAQLLNL SAPEMTVLVG GLRVLNTNYD
660 670 680 690 700
GSAHGVFTSR PGVLSNDFFV NLLDMNTAWQ AGHNGEIFEG ADRKSGAKKW
710 720 730 740 750
TATRADLVFG SHAELRAVAE VYASADGQRK FVNDFVAAWN KVMNLDRFDL
760
QGKQFIYPRL
Length:760
Mass (Da):83,843
Last modified:January 23, 2007 - v1
Checksum:iF4ED7671BC8562C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027046 Genomic DNA. Translation: EAW13700.1.
RefSeqiXP_001275126.1. XM_001275125.1.

Genome annotation databases

EnsemblFungiiCADACLAT00004125; CADACLAP00004027; CADACLAG00004125.
GeneIDi4707337.
KEGGiact:ACLA_044200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027046 Genomic DNA. Translation: EAW13700.1.
RefSeqiXP_001275126.1. XM_001275125.1.

3D structure databases

ProteinModelPortaliA1C8R3.
SMRiA1C8R3. Positions 21-750.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA1C8R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00004125; CADACLAP00004027; CADACLAG00004125.
GeneIDi4707337.
KEGGiact:ACLA_044200.

Organism-specific databases

EuPathDBiFungiDB:ACLA_044200.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ASPCL
AccessioniPrimary (citable) accession number: A1C8R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.