ID   XLNR_ASPCL              Reviewed;         978 AA.
AC   A1C7P9;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=Xylanolytic transcriptional activator xlnR;
DE   AltName: Full=Xylanase regulator;
GN   Name=xlnR; ORFNames=ACLA_074570;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Transcriptional activator of the xylanolytic system. Involved
CC       in the regulation of extracellular cellulolytic and xylanolytic genes
CC       and in the regulation of the intracellular activities of D-xylose
CC       catabolic genes in the pentose catabolic pathway (PCP) in response to
CC       the presence of D-xylose (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the xlnR/xlr1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW14420.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DS027045; EAW14420.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001275846.1; XM_001275845.1.
DR   AlphaFoldDB; A1C7P9; -.
DR   SMR; A1C7P9; -.
DR   STRING; 344612.A1C7P9; -.
DR   EnsemblFungi; EAW14420; EAW14420; ACLA_074570.
DR   GeneID; 4707549; -.
DR   KEGG; act:ACLA_074570; -.
DR   eggNOG; ENOG502QUI0; Eukaryota.
DR   OrthoDB; 2734143at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR   GO; GO:0045493; P:xylan catabolic process; ISS:UniProtKB.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; Zn(2)-C6 fungal-type DNA-binding domain; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   InterPro; IPR001138; Zn2Cys6_DnaBD.
DR   PANTHER; PTHR47663; XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED; 1.
DR   PANTHER; PTHR47663:SF1; XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED; 1.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..978
FT                   /note="Xylanolytic transcriptional activator xlnR"
FT                   /id="PRO_0000393148"
FT   DNA_BIND        140..166
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   978 AA;  106488 MW;  4EF80E9CCF68E95B CRC64;
     MSTTSVQHFA PSYPPFSSGL SSNRMAQSQT PGLDTLAEGS QYALEQLQLS REAAAGDTTA
     TAASGPSDPM SKSKDPYDFD HHNHNHHNHH NNNHHPNSNS NNSLPGFKNP AQRDPLAEAR
     SAIRKNSSSA PVRRRISRAC DQCNQLRTRC DGQNPCAHCI EFGLTCEYAR ERKKRGKASK
     KDLAAAAAAA TATPGQPNEN PGKDSGTMVG GHSPPDRRQE LNGRYDPAFD AARNLSGSAQ
     PQLPHAEGPG MVGMPNTQHL PSPSQPPMGG GLEGLPMNGY NGLNDSNRPP IPVSELQSLH
     MLHSSNPHPR SPPSILPSQR YNGGYNENAY SLMNPQEHNP TPMNQFRLGN STENPPNTFL
     GLSPPAQSPG WLPLPSPSPA NFPSFSMASF STTLRYPVLH PVLPHIASII PQSLACDLLD
     VYFTSSSSSH LSPQSPYVVG YIFRKQSFLH PTKPRACSPG LLASMLWVAA QTSDAPFLTS
     PPSARGRVCQ KLLELTVGLL RPLIHGPAPG ETSPNYAANM VINGIALGGF GVSMDQLGAQ
     SSATGAVDDV ATYVHLATVI SASEYKAASM RWWTAAWSLA RELKLGRELP PNTSQTRQDG
     ERENDPDADP SNRHSPSLIT AMGHGPGNTV INVTEDEREE RRRLWWLLYA TDRHLALCYN
     RPLTLLDKEC NGLLQPMNDD LWQASDFASA SYRQAGPPLE CSGHSMFGYF LPLMTILGEI
     IDLQQARNHP RFGLAFRGSP ECDAQVLEIA RQLDLYAQTL KEFETRYTSG LALGAADNDT
     AMEGSHLNHV SPSGRSSSTV DSRVNESIVH TKMVVAYGTH IMHVLHILLA GKWDPINLLD
     DNDLWISSES FIAAMGHAVG AAEAAADILE YDPDLSFMPF FFGIYLLQGS FLLLLTADKL
     QGDASPSVVR ACETIVRAHE ACVVTLNTEY QRTFRKVMRS ALAQVRGRLP EDFGEQQQRR
     REVLALYRWT GDGSGLAL
//