Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1C7E9 (NCB5R_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-cytochrome b5 reductase 1
EC=1.6.2.2
Alternative name(s):
Microsomal cytochrome b reductase
Gene names
Name:cbr1
ORF Names:ACLA_073550
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes By similarity.

Catalytic activity

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

Cofactor

FAD By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309NADH-cytochrome b5 reductase 1
PRO_0000330144

Regions

Transmembrane29 – 4921Helical; Potential
Domain60 – 165106FAD-binding FR-type
Nucleotide binding145 – 16016FAD By similarity
Nucleotide binding171 – 20838FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A1C7E9 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 214157BBE69E47B3

FASTA30933,772
        10         20         30         40         50         60 
MSALSSENVN GVYIPSALLV FGTFLVKKEF VPYAVALTAV LAGFKLFTGD SKARKVLNPT 

        70         80         90        100        110        120 
EFQEFVLKEK TDISHNVSIY RFALPRPTDI LGLPIGQHIS LAATIEGQPK EVVRSYTPIS 

       130        140        150        160        170        180 
SDNEAGYFDL LVKAYPQGNI SKHLTTLKVG DVMKVRGPKG AMVYTPNMCR HIGMIAGGTG 

       190        200        210        220        230        240 
ITPMLQVIKA IIRNRPRNGG TDITKVDLIF ANVNPEDILL KEELDKLAAE DEDFNIYYVL 

       250        260        270        280        290        300 
NNPPQGWTGG VGFVTPEMIK ERLPAPASDV KVLLCGPPPM ISAMKKATES LGFTKARPVS 


KLEDQVFCF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS027045 Genomic DNA. Translation: EAW14320.1.
RefSeqXP_001275746.1. XM_001275745.1.

3D structure databases

ProteinModelPortalA1C7E9.
SMRA1C7E9. Positions 52-296.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00006564; CADACLAP00006404; CADACLAG00006564.
GeneID4707891.
KEGGact:ACLA_073550.

Phylogenomic databases

GeneTreeEFGT00050000001026.
OrthoDBEOG4FFH9R.

Family and domain databases

InterProIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
KOK00326.
PfamPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMSSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCB5R_ASPCL
AccessionPrimary (citable) accession number: A1C7E9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents