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A1C7B5

- EGLX_ASPCL

UniProt

A1C7B5 - EGLX_ASPCL

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Protein

Probable endo-1,3(4)-beta-glucanase ACLA_073210

Gene

ACLA_073210

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461NucleophileBy similarity
Active sitei151 – 1511Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase ACLA_073210 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase ACLA_073210
Gene namesi
ORF Names:ACLA_073210
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 617596Probable endo-1,3(4)-beta-glucanase ACLA_073210PRO_0000395082Add
BLAST
Propeptidei618 – 63922Removed in mature formSequence AnalysisPRO_0000395083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Lipidationi617 – 6171GPI-anchor amidated alanineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA1C7B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi357 – 43680Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
OMAiIESKKYY.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000757. Glyco_hydro_16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1C7B5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPSSLLLSV GSLIASSLAS ATSLQIREQS QSYQLTESWQ GESFINDWNF
60 70 80 90 100
FDRGDPTNGY VTYVNQSVAE SSGLVKVTQS GSFYMGVDYE SKLNPDGPGR
110 120 130 140 150
ESVRIESKKY YTQGLYVVDI AHMPGSICGT WPAFWSVGAN WPHDGEIDII
160 170 180 190 200
EGVNKHDANE IVLHTSGSCD VAGSHDMTGS LTSGECGDAS GTIGCVVKGT
210 220 230 240 250
QGSAGDPFNA QGGGVYAIEW TDSFLKIWFF PRNSIPASIT AGKPDSSAFG
260 270 280 290 300
TPMAHLQGTC DFAERFKEQK FILDTTFCGD WAGNVFGESG CPLSDASSPM
310 320 330 340 350
RSCVDYVAQN PAAFKEAYWE INSIKIYQLG AAPAPATVAS PNTASEVHSA
360 370 380 390 400
SELAPATQTE KPTVPTAAET TVVPPASQTS TVAEETPIAP LATAATVTAV
410 420 430 440 450
NPAPPATQPT AEPATAVTVT DGGDSFRTIF LTSTTTICPE AQSSSSAAAH
460 470 480 490 500
GGNKNAPVGA VPGQPSGADA VGNPNPSTTT EAVAETETSQ PELTAGGISE
510 520 530 540 550
LPKSAPAPTA SQPTSEFKPS DVPDVPKPSP EAEHPAPPAA AGSSIINTPS
560 570 580 590 600
SSAIFGSSTA VGTFTSLARV SRPTGGATFV PTIATATGSP TVGEDGSSGS
610 620 630
ATASATLTAP TGILFTAGAR KLSVGLSGLV GALAVAALA
Length:639
Mass (Da):65,108
Last modified:January 23, 2007 - v1
Checksum:i5CF35BA52DF084C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027045 Genomic DNA. Translation: EAW14286.1.
RefSeqiXP_001275712.1. XM_001275711.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006512; CADACLAP00006352; CADACLAG00006512.
GeneIDi4708021.
KEGGiact:ACLA_073210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027045 Genomic DNA. Translation: EAW14286.1 .
RefSeqi XP_001275712.1. XM_001275711.1.

3D structure databases

ProteinModelPortali A1C7B5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00006512 ; CADACLAP00006352 ; CADACLAG00006512 .
GeneIDi 4708021.
KEGGi act:ACLA_073210.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
OMAi IESKKYY.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000757. Glyco_hydro_16.
[Graphical view ]
Pfami PF00722. Glyco_hydro_16. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiEGLX_ASPCL
AccessioniPrimary (citable) accession number: A1C7B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3