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Protein

Probable endo-1,3(4)-beta-glucanase ACLA_073210

Gene

ACLA_073210

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146NucleophileBy similarity1
Active sitei151Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase ACLA_073210 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase ACLA_073210
Gene namesi
ORF Names:ACLA_073210
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_073210.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000039508222 – 617Probable endo-1,3(4)-beta-glucanase ACLA_073210Add BLAST596
PropeptideiPRO_0000395083618 – 639Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Lipidationi617GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiA1C7B5.

Structurei

3D structure databases

ProteinModelPortaliA1C7B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 290GH16PROSITE-ProRule annotationAdd BLAST265

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi357 – 436Thr-richAdd BLAST80

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated
Contains 1 GH16 (glycosyl hydrolase family 16) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000166269.
OMAiIESKKYY.
OrthoDBiEOG092C3D34.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000757. GH16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51762. GH16_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1C7B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSSLLLSV GSLIASSLAS ATSLQIREQS QSYQLTESWQ GESFINDWNF
60 70 80 90 100
FDRGDPTNGY VTYVNQSVAE SSGLVKVTQS GSFYMGVDYE SKLNPDGPGR
110 120 130 140 150
ESVRIESKKY YTQGLYVVDI AHMPGSICGT WPAFWSVGAN WPHDGEIDII
160 170 180 190 200
EGVNKHDANE IVLHTSGSCD VAGSHDMTGS LTSGECGDAS GTIGCVVKGT
210 220 230 240 250
QGSAGDPFNA QGGGVYAIEW TDSFLKIWFF PRNSIPASIT AGKPDSSAFG
260 270 280 290 300
TPMAHLQGTC DFAERFKEQK FILDTTFCGD WAGNVFGESG CPLSDASSPM
310 320 330 340 350
RSCVDYVAQN PAAFKEAYWE INSIKIYQLG AAPAPATVAS PNTASEVHSA
360 370 380 390 400
SELAPATQTE KPTVPTAAET TVVPPASQTS TVAEETPIAP LATAATVTAV
410 420 430 440 450
NPAPPATQPT AEPATAVTVT DGGDSFRTIF LTSTTTICPE AQSSSSAAAH
460 470 480 490 500
GGNKNAPVGA VPGQPSGADA VGNPNPSTTT EAVAETETSQ PELTAGGISE
510 520 530 540 550
LPKSAPAPTA SQPTSEFKPS DVPDVPKPSP EAEHPAPPAA AGSSIINTPS
560 570 580 590 600
SSAIFGSSTA VGTFTSLARV SRPTGGATFV PTIATATGSP TVGEDGSSGS
610 620 630
ATASATLTAP TGILFTAGAR KLSVGLSGLV GALAVAALA
Length:639
Mass (Da):65,108
Last modified:January 23, 2007 - v1
Checksum:i5CF35BA52DF084C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027045 Genomic DNA. Translation: EAW14286.1.
RefSeqiXP_001275712.1. XM_001275711.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006512; CADACLAP00006352; CADACLAG00006512.
GeneIDi4708021.
KEGGiact:ACLA_073210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027045 Genomic DNA. Translation: EAW14286.1.
RefSeqiXP_001275712.1. XM_001275711.1.

3D structure databases

ProteinModelPortaliA1C7B5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA1C7B5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00006512; CADACLAP00006352; CADACLAG00006512.
GeneIDi4708021.
KEGGiact:ACLA_073210.

Organism-specific databases

EuPathDBiFungiDB:ACLA_073210.

Phylogenomic databases

HOGENOMiHOG000166269.
OMAiIESKKYY.
OrthoDBiEOG092C3D34.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000757. GH16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51762. GH16_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGLX_ASPCL
AccessioniPrimary (citable) accession number: A1C7B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.