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A1C7B5

- EGLX_ASPCL

UniProt

A1C7B5 - EGLX_ASPCL

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Protein

Probable endo-1,3(4)-beta-glucanase ACLA_073210

Gene
ACLA_073210
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates By similarity.

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461Nucleophile By similarity
Active sitei151 – 1511Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase ACLA_073210 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase ACLA_073210
Gene namesi
ORF Names:ACLA_073210
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 617596Probable endo-1,3(4)-beta-glucanase ACLA_073210PRO_0000395082Add
BLAST
Propeptidei618 – 63922Removed in mature form Reviewed predictionPRO_0000395083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Lipidationi617 – 6171GPI-anchor amidated alanine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA1C7B5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi357 – 43680Thr-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
OMAiIESKKYY.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1C7B5-1 [UniParc]FASTAAdd to Basket

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MAPSSLLLSV GSLIASSLAS ATSLQIREQS QSYQLTESWQ GESFINDWNF    50
FDRGDPTNGY VTYVNQSVAE SSGLVKVTQS GSFYMGVDYE SKLNPDGPGR 100
ESVRIESKKY YTQGLYVVDI AHMPGSICGT WPAFWSVGAN WPHDGEIDII 150
EGVNKHDANE IVLHTSGSCD VAGSHDMTGS LTSGECGDAS GTIGCVVKGT 200
QGSAGDPFNA QGGGVYAIEW TDSFLKIWFF PRNSIPASIT AGKPDSSAFG 250
TPMAHLQGTC DFAERFKEQK FILDTTFCGD WAGNVFGESG CPLSDASSPM 300
RSCVDYVAQN PAAFKEAYWE INSIKIYQLG AAPAPATVAS PNTASEVHSA 350
SELAPATQTE KPTVPTAAET TVVPPASQTS TVAEETPIAP LATAATVTAV 400
NPAPPATQPT AEPATAVTVT DGGDSFRTIF LTSTTTICPE AQSSSSAAAH 450
GGNKNAPVGA VPGQPSGADA VGNPNPSTTT EAVAETETSQ PELTAGGISE 500
LPKSAPAPTA SQPTSEFKPS DVPDVPKPSP EAEHPAPPAA AGSSIINTPS 550
SSAIFGSSTA VGTFTSLARV SRPTGGATFV PTIATATGSP TVGEDGSSGS 600
ATASATLTAP TGILFTAGAR KLSVGLSGLV GALAVAALA 639
Length:639
Mass (Da):65,108
Last modified:January 23, 2007 - v1
Checksum:i5CF35BA52DF084C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027045 Genomic DNA. Translation: EAW14286.1.
RefSeqiXP_001275712.1. XM_001275711.1.

Genome annotation databases

EnsemblFungiiCADACLAT00006512; CADACLAP00006352; CADACLAG00006512.
GeneIDi4708021.
KEGGiact:ACLA_073210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027045 Genomic DNA. Translation: EAW14286.1 .
RefSeqi XP_001275712.1. XM_001275711.1.

3D structure databases

ProteinModelPortali A1C7B5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00006512 ; CADACLAP00006352 ; CADACLAG00006512 .
GeneIDi 4708021.
KEGGi act:ACLA_073210.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
OMAi IESKKYY.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view ]
Pfami PF00722. Glyco_hydro_16. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiEGLX_ASPCL
AccessioniPrimary (citable) accession number: A1C7B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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