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A1C7B5

- EGLX_ASPCL

UniProt

A1C7B5 - EGLX_ASPCL

Protein

Probable endo-1,3(4)-beta-glucanase ACLA_073210

Gene

ACLA_073210

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

    Catalytic activityi

    Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei146 – 1461NucleophileBy similarity
    Active sitei151 – 1511Proton donorBy similarity

    GO - Molecular functioni

    1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
    2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable endo-1,3(4)-beta-glucanase ACLA_073210 (EC:3.2.1.6)
    Alternative name(s):
    Mixed-linked glucanase ACLA_073210
    Gene namesi
    ORF Names:ACLA_073210
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 617596Probable endo-1,3(4)-beta-glucanase ACLA_073210PRO_0000395082Add
    BLAST
    Propeptidei618 – 63922Removed in mature formSequence AnalysisPRO_0000395083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Lipidationi617 – 6171GPI-anchor amidated alanineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA1C7B5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi357 – 43680Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 16 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000166269.
    OMAiIESKKYY.
    OrthoDBiEOG7HB5KN.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    [Graphical view]
    PfamiPF00722. Glyco_hydro_16. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1C7B5-1 [UniParc]FASTAAdd to Basket

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    MAPSSLLLSV GSLIASSLAS ATSLQIREQS QSYQLTESWQ GESFINDWNF    50
    FDRGDPTNGY VTYVNQSVAE SSGLVKVTQS GSFYMGVDYE SKLNPDGPGR 100
    ESVRIESKKY YTQGLYVVDI AHMPGSICGT WPAFWSVGAN WPHDGEIDII 150
    EGVNKHDANE IVLHTSGSCD VAGSHDMTGS LTSGECGDAS GTIGCVVKGT 200
    QGSAGDPFNA QGGGVYAIEW TDSFLKIWFF PRNSIPASIT AGKPDSSAFG 250
    TPMAHLQGTC DFAERFKEQK FILDTTFCGD WAGNVFGESG CPLSDASSPM 300
    RSCVDYVAQN PAAFKEAYWE INSIKIYQLG AAPAPATVAS PNTASEVHSA 350
    SELAPATQTE KPTVPTAAET TVVPPASQTS TVAEETPIAP LATAATVTAV 400
    NPAPPATQPT AEPATAVTVT DGGDSFRTIF LTSTTTICPE AQSSSSAAAH 450
    GGNKNAPVGA VPGQPSGADA VGNPNPSTTT EAVAETETSQ PELTAGGISE 500
    LPKSAPAPTA SQPTSEFKPS DVPDVPKPSP EAEHPAPPAA AGSSIINTPS 550
    SSAIFGSSTA VGTFTSLARV SRPTGGATFV PTIATATGSP TVGEDGSSGS 600
    ATASATLTAP TGILFTAGAR KLSVGLSGLV GALAVAALA 639
    Length:639
    Mass (Da):65,108
    Last modified:January 23, 2007 - v1
    Checksum:i5CF35BA52DF084C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027045 Genomic DNA. Translation: EAW14286.1.
    RefSeqiXP_001275712.1. XM_001275711.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00006512; CADACLAP00006352; CADACLAG00006512.
    GeneIDi4708021.
    KEGGiact:ACLA_073210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027045 Genomic DNA. Translation: EAW14286.1 .
    RefSeqi XP_001275712.1. XM_001275711.1.

    3D structure databases

    ProteinModelPortali A1C7B5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00006512 ; CADACLAP00006352 ; CADACLAG00006512 .
    GeneIDi 4708021.
    KEGGi act:ACLA_073210.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000166269.
    OMAi IESKKYY.
    OrthoDBi EOG7HB5KN.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    [Graphical view ]
    Pfami PF00722. Glyco_hydro_16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiEGLX_ASPCL
    AccessioniPrimary (citable) accession number: A1C7B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3