A1C6L9 (CREA_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable DNA-binding protein creA

Alternative name(s):
Carbon catabolite repressor A

Gene names

Name:	creA
ORF Names:	ACLA_070730

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus clavatus

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.
Subunit structure	Interacts with creB By similarity.
Subcellular location	Nucleus By similarity.
Post-translational modification	Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount By similarity.
Sequence similarities	Belongs to the creA/MIG C2H2-type zinc-finger protein family. Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Probable DNA-binding protein creA		PRO_0000395720
Regions
	Zinc finger	75 – 97	23	C2H2-type 1
	Zinc finger	103 – 127	25	C2H2-type 2
	Compositional bias	142 – 149	8	Poly-Ala
	Compositional bias	288 – 392	105	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	A1C6L9 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: B53576055C150DAD	FASTA	425	45,972
	10 20 30 40 50 60 MPPSASSVGF SDLLNPQNPT ESAPSTPVNK SPASSAPSSA QSNSTMASSV SLLPPLMKGT 70 80 90 100 110 120 RPANEEPRQD LPRPYKCPLC DRAFHRLEHQ TRHIRTHTGE KPHACQFPGC TKRFSRSDEL 130 140 150 160 170 180 TRHSRIHNNP NSRRNNKAQH LAAAAAAAAN QDNVLVNNTG SMMPPPSKPI TRSAPVSQVG 190 200 210 220 230 240 SPDISPPHSF TNYAGHMRSN LGPYARNNER ASSGMDINLL ATAASQVERD EHFGFHNGPR 250 260 270 280 290 300 GLPLFSSRLH NSSRLPSLSA YAISQNMTRS HSHDEEDVYS HRVKRSRPNS PNSTAPSSPT 310 320 330 340 350 360 FSHDSLSPTP DHTPLATPAH SPRLRPLGTS ELQLPSIRHL SLHHTPALAP MEPQPEGPNY 370 380 390 400 410 420 YSPTQPHHGP SISDIMSKPD GTQRKLPVPQ VPKVAVQDML NPTGFVSVSS STSNSVAGGD LAERF

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027045 Genomic DNA. Translation: EAW14040.1.
RefSeq	XP_001275466.1. XM_001275465.1.
3D structure databases
ProteinModelPortal	A1C6L9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00007172; CADACLAP00007012; CADACLAG00007172.
GeneID	4708318.
KEGG	act:ACLA_070730.
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000164217.
KO	K09467.
OrthoDB	EOG41G6D6.
Family and domain databases
Gene3D	3.30.160.60. 2 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 2 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CREA_ASPCL

Accession

Primary (citable) accession number: A1C6L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program