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A1C6L9 (CREA_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA-binding protein creA
Alternative name(s):
Carbon catabolite repressor A
Gene names
Name:creA
ORF Names:ACLA_070730
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Subunit structure

Interacts with creB By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount By similarity.

Sequence similarities

Belongs to the creA/MIG C2H2-type zinc-finger protein family.

Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   PTMUbl conjugation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Probable DNA-binding protein creA
PRO_0000395720

Regions

Zinc finger75 – 9723C2H2-type 1
Zinc finger103 – 12725C2H2-type 2
Compositional bias142 – 1498Poly-Ala
Compositional bias288 – 392105Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A1C6L9 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: B53576055C150DAD

FASTA42545,972
        10         20         30         40         50         60 
MPPSASSVGF SDLLNPQNPT ESAPSTPVNK SPASSAPSSA QSNSTMASSV SLLPPLMKGT 

        70         80         90        100        110        120 
RPANEEPRQD LPRPYKCPLC DRAFHRLEHQ TRHIRTHTGE KPHACQFPGC TKRFSRSDEL 

       130        140        150        160        170        180 
TRHSRIHNNP NSRRNNKAQH LAAAAAAAAN QDNVLVNNTG SMMPPPSKPI TRSAPVSQVG 

       190        200        210        220        230        240 
SPDISPPHSF TNYAGHMRSN LGPYARNNER ASSGMDINLL ATAASQVERD EHFGFHNGPR 

       250        260        270        280        290        300 
GLPLFSSRLH NSSRLPSLSA YAISQNMTRS HSHDEEDVYS HRVKRSRPNS PNSTAPSSPT 

       310        320        330        340        350        360 
FSHDSLSPTP DHTPLATPAH SPRLRPLGTS ELQLPSIRHL SLHHTPALAP MEPQPEGPNY 

       370        380        390        400        410        420 
YSPTQPHHGP SISDIMSKPD GTQRKLPVPQ VPKVAVQDML NPTGFVSVSS STSNSVAGGD 


LAERF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027045 Genomic DNA. Translation: EAW14040.1.
RefSeqXP_001275466.1. XM_001275465.1.

3D structure databases

ProteinModelPortalA1C6L9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00007012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00007172; CADACLAP00007012; CADACLAG00007172.
GeneID4708318.
KEGGact:ACLA_070730.

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000164217.
KOK09467.
OMARIHSNPN.
OrthoDBEOG7K0ZMS.

Family and domain databases

Gene3D3.30.160.60. 2 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCREA_ASPCL
AccessionPrimary (citable) accession number: A1C6L9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families