Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1C6L9

- CREA_ASPCL

UniProt

A1C6L9 - CREA_ASPCL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable DNA-binding protein creA

Gene

creA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 9723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-binding protein creA
Alternative name(s):
Carbon catabolite repressor A
Gene namesi
Name:creA
ORF Names:ACLA_070730
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Probable DNA-binding protein creAPRO_0000395720Add
BLAST

Post-translational modificationi

Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with creB.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00007012.

Structurei

3D structure databases

ProteinModelPortaliA1C6L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 1498Poly-Ala
Compositional biasi288 – 392105Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 9723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000164217.
KOiK09467.
OMAiRIHSNPN.
OrthoDBiEOG7K0ZMS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C6L9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPSASSVGF SDLLNPQNPT ESAPSTPVNK SPASSAPSSA QSNSTMASSV
60 70 80 90 100
SLLPPLMKGT RPANEEPRQD LPRPYKCPLC DRAFHRLEHQ TRHIRTHTGE
110 120 130 140 150
KPHACQFPGC TKRFSRSDEL TRHSRIHNNP NSRRNNKAQH LAAAAAAAAN
160 170 180 190 200
QDNVLVNNTG SMMPPPSKPI TRSAPVSQVG SPDISPPHSF TNYAGHMRSN
210 220 230 240 250
LGPYARNNER ASSGMDINLL ATAASQVERD EHFGFHNGPR GLPLFSSRLH
260 270 280 290 300
NSSRLPSLSA YAISQNMTRS HSHDEEDVYS HRVKRSRPNS PNSTAPSSPT
310 320 330 340 350
FSHDSLSPTP DHTPLATPAH SPRLRPLGTS ELQLPSIRHL SLHHTPALAP
360 370 380 390 400
MEPQPEGPNY YSPTQPHHGP SISDIMSKPD GTQRKLPVPQ VPKVAVQDML
410 420
NPTGFVSVSS STSNSVAGGD LAERF
Length:425
Mass (Da):45,972
Last modified:January 23, 2007 - v1
Checksum:iB53576055C150DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027045 Genomic DNA. Translation: EAW14040.1.
RefSeqiXP_001275466.1. XM_001275465.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007172; CADACLAP00007012; CADACLAG00007172.
GeneIDi4708318.
KEGGiact:ACLA_070730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027045 Genomic DNA. Translation: EAW14040.1 .
RefSeqi XP_001275466.1. XM_001275465.1.

3D structure databases

ProteinModelPortali A1C6L9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00007172 ; CADACLAP00007012 ; CADACLAG00007172 .
GeneIDi 4708318.
KEGGi act:ACLA_070730.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000164217.
KOi K09467.
OMAi RIHSNPN.
OrthoDBi EOG7K0ZMS.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiCREA_ASPCL
AccessioniPrimary (citable) accession number: A1C6L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3