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Protein

Probable DNA-binding protein creA

Gene

creA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 9723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-binding protein creA
Alternative name(s):
Carbon catabolite repressor A
Gene namesi
Name:creA
ORF Names:ACLA_070730
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_070730.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Probable DNA-binding protein creAPRO_0000395720Add
BLAST

Post-translational modificationi

Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with creB.By similarity

Structurei

3D structure databases

ProteinModelPortaliA1C6L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 1498Poly-Ala
Compositional biasi288 – 392105Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 9723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000164217.
KOiK09467.
OMAiRIHSNPN.
OrthoDBiEOG7K0ZMS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C6L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSASSVGF SDLLNPQNPT ESAPSTPVNK SPASSAPSSA QSNSTMASSV
60 70 80 90 100
SLLPPLMKGT RPANEEPRQD LPRPYKCPLC DRAFHRLEHQ TRHIRTHTGE
110 120 130 140 150
KPHACQFPGC TKRFSRSDEL TRHSRIHNNP NSRRNNKAQH LAAAAAAAAN
160 170 180 190 200
QDNVLVNNTG SMMPPPSKPI TRSAPVSQVG SPDISPPHSF TNYAGHMRSN
210 220 230 240 250
LGPYARNNER ASSGMDINLL ATAASQVERD EHFGFHNGPR GLPLFSSRLH
260 270 280 290 300
NSSRLPSLSA YAISQNMTRS HSHDEEDVYS HRVKRSRPNS PNSTAPSSPT
310 320 330 340 350
FSHDSLSPTP DHTPLATPAH SPRLRPLGTS ELQLPSIRHL SLHHTPALAP
360 370 380 390 400
MEPQPEGPNY YSPTQPHHGP SISDIMSKPD GTQRKLPVPQ VPKVAVQDML
410 420
NPTGFVSVSS STSNSVAGGD LAERF
Length:425
Mass (Da):45,972
Last modified:January 23, 2007 - v1
Checksum:iB53576055C150DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027045 Genomic DNA. Translation: EAW14040.1.
RefSeqiXP_001275466.1. XM_001275465.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007172; CADACLAP00007012; CADACLAG00007172.
GeneIDi4708318.
KEGGiact:ACLA_070730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027045 Genomic DNA. Translation: EAW14040.1.
RefSeqiXP_001275466.1. XM_001275465.1.

3D structure databases

ProteinModelPortaliA1C6L9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00007172; CADACLAP00007012; CADACLAG00007172.
GeneIDi4708318.
KEGGiact:ACLA_070730.

Organism-specific databases

EuPathDBiFungiDB:ACLA_070730.

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000164217.
KOiK09467.
OMAiRIHSNPN.
OrthoDBiEOG7K0ZMS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiCREA_ASPCL
AccessioniPrimary (citable) accession number: A1C6L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.