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A1C6L9

- CREA_ASPCL

UniProt

A1C6L9 - CREA_ASPCL

Protein

Probable DNA-binding protein creA

Gene

creA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri75 – 9723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 12725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA-binding protein creA
    Alternative name(s):
    Carbon catabolite repressor A
    Gene namesi
    Name:creA
    ORF Names:ACLA_070730
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Probable DNA-binding protein creAPRO_0000395720Add
    BLAST

    Post-translational modificationi

    Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with creB.By similarity

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00007012.

    Structurei

    3D structure databases

    ProteinModelPortaliA1C6L9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi142 – 1498Poly-Ala
    Compositional biasi288 – 392105Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri75 – 9723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri103 – 12725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000164217.
    KOiK09467.
    OMAiRIHSNPN.
    OrthoDBiEOG7K0ZMS.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1C6L9-1 [UniParc]FASTAAdd to Basket

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    MPPSASSVGF SDLLNPQNPT ESAPSTPVNK SPASSAPSSA QSNSTMASSV    50
    SLLPPLMKGT RPANEEPRQD LPRPYKCPLC DRAFHRLEHQ TRHIRTHTGE 100
    KPHACQFPGC TKRFSRSDEL TRHSRIHNNP NSRRNNKAQH LAAAAAAAAN 150
    QDNVLVNNTG SMMPPPSKPI TRSAPVSQVG SPDISPPHSF TNYAGHMRSN 200
    LGPYARNNER ASSGMDINLL ATAASQVERD EHFGFHNGPR GLPLFSSRLH 250
    NSSRLPSLSA YAISQNMTRS HSHDEEDVYS HRVKRSRPNS PNSTAPSSPT 300
    FSHDSLSPTP DHTPLATPAH SPRLRPLGTS ELQLPSIRHL SLHHTPALAP 350
    MEPQPEGPNY YSPTQPHHGP SISDIMSKPD GTQRKLPVPQ VPKVAVQDML 400
    NPTGFVSVSS STSNSVAGGD LAERF 425
    Length:425
    Mass (Da):45,972
    Last modified:January 23, 2007 - v1
    Checksum:iB53576055C150DAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027045 Genomic DNA. Translation: EAW14040.1.
    RefSeqiXP_001275466.1. XM_001275465.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00007172; CADACLAP00007012; CADACLAG00007172.
    GeneIDi4708318.
    KEGGiact:ACLA_070730.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027045 Genomic DNA. Translation: EAW14040.1 .
    RefSeqi XP_001275466.1. XM_001275465.1.

    3D structure databases

    ProteinModelPortali A1C6L9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00007012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00007172 ; CADACLAP00007012 ; CADACLAG00007172 .
    GeneIDi 4708318.
    KEGGi act:ACLA_070730.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000164217.
    KOi K09467.
    OMAi RIHSNPN.
    OrthoDBi EOG7K0ZMS.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiCREA_ASPCL
    AccessioniPrimary (citable) accession number: A1C6L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3