A1C6B4 (MTLD_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17

Gene names

Name:	mpdA
ORF Names:	ACLA_069650

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371518
Regions
	Nucleotide binding	5 – 16	12	NAD By similarity
Sites
	Active site	213	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1C6B4 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: FDA96CB8107A86D5	FASTA	388	42,661
	10 20 30 40 50 60 MGKKAIQFGG GNIGRGFVAE FLHEAGYEVV FVDVMDKIID ALTSNPSYQV TEVSDEGERT 70 80 90 100 110 120 KTITNYSAIN SKTHESEVVQ EIATADVVTC AVGPNILKFI APVIAKGIDA RTASKPLAVI 130 140 150 160 170 180 ACENAIGATD TLHGFIKQNT DESRLSTMGE RAQFANSAID RIVPNQPAGE GLNVRIEKFY 190 200 210 220 230 240 EWVVEKTPFG SVGHPDIPAI HWVDHLEPYI ERKLFTVNTG HATTAYYGYQ RGKKMIAEAL 250 260 270 280 290 300 ADPEIRQIVH QVLEETASLI VAKHEISEEE QKEYVNTIIS RISNPYLEDN VERVGRAPLR 310 320 330 340 350 360 KLSRKERFIG PAAQLAEKGM KYDALLGSVE MALRFQNVPG DEESVELAKI LNEMSADDAT 370 380 AKLTGLEKSH PLYQPVQNVV AKVQKGGK

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027045 Genomic DNA. Translation: EAW13935.1.
RefSeq	XP_001275361.1. XM_001275360.1.
3D structure databases
ProteinModelPortal	A1C6B4.
ModBase	Search...
Protein-protein interaction databases
STRING	A1C6B4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00006747; CADACLAP00006587; CADACLAG00006747.
GeneID	4707562.
KEGG	act:ACLA_069650.
Phylogenomic databases
GeneTree	EFGT00050000004394.
OrthoDB	EOG469V3C.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ASPCL

Accession

Primary (citable) accession number: A1C6B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program