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Protein

Histone H2A.Z

Gene

HTZ1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and spt15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity).By similarity

GO - Molecular functioni

  1. chromatin DNA binding Source: EnsemblFungi
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: EnsemblFungi

GO - Biological processi

  1. chromatin silencing at silent mating-type cassette Source: EnsemblFungi
  2. DNA-templated transcription, termination Source: EnsemblFungi
  3. histone exchange Source: EnsemblFungi
  4. nuclear-transcribed mRNA catabolic process, non-stop decay Source: EnsemblFungi
  5. regulation of transcription from RNA polymerase II promoter Source: EnsemblFungi
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.Z
Gene namesi
Name:HTZ1
ORF Names:ACLA_003310
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701 Componenti: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. Ino80 complex Source: EnsemblFungi
  2. mitochondrion Source: EnsemblFungi
  3. nuclear euchromatin Source: EnsemblFungi
  4. nucleosome Source: UniProtKB-KW
  5. Swr1 complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Histone H2A.ZPRO_0000297717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51N6-acetyllysineBy similarity
Modified residuei12 – 121N6-acetyllysineBy similarity

Post-translational modificationi

Acetylated once deposited into chromatin.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiA1C5F1.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the vps72/swc2 subunit of the SWR1 chromatin remodeling complex. Interacts also with rbp1/DNA-directed RNA polymerase II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00000308.

Structurei

3D structure databases

ProteinModelPortaliA1C5F1.
SMRiA1C5F1. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiCOG5262.
HOGENOMiHOG000234652.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG7GN30N.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

A1C5F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGKGKSVG GKAGSKDAAG KTQKSHSAKA GLQFPCGRVK RFLKNNTQNK
60 70 80 90 100
MRVGAKAAVY VTAVLEYLTA EVLELAGNAA KDLKVKRITP RHLQLAIRGD
110 120 130
EELDTLIRAT IAFGGVLPRI NRALLLKVEQ KKKNKSEA
Length:138
Mass (Da):14,820
Last modified:January 23, 2007 - v1
Checksum:i9B192C6C43C211E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027004 Genomic DNA. Translation: EAW14919.1.
RefSeqiXP_001276345.1. XM_001276344.1.

Genome annotation databases

EnsemblFungiiCADACLAT00000312; CADACLAP00000308; CADACLAG00000312.
GeneIDi4708462.
KEGGiact:ACLA_003310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027004 Genomic DNA. Translation: EAW14919.1.
RefSeqiXP_001276345.1. XM_001276344.1.

3D structure databases

ProteinModelPortaliA1C5F1.
SMRiA1C5F1. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00000308.

Proteomic databases

PRIDEiA1C5F1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00000312; CADACLAP00000308; CADACLAG00000312.
GeneIDi4708462.
KEGGiact:ACLA_003310.

Phylogenomic databases

eggNOGiCOG5262.
HOGENOMiHOG000234652.
KOiK11251.
OMAiIHRYLMN.
OrthoDBiEOG7GN30N.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiH2AZ_ASPCL
AccessioniPrimary (citable) accession number: A1C5F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.