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Protein

Histone H2A.Z

Gene

HTZ1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and spt15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.Z
Gene namesi
Name:HTZ1
ORF Names:ACLA_003310
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:ACLA_003310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002977171 – 138Histone H2A.ZAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-acetyllysineBy similarity1
Modified residuei12N6-acetyllysineBy similarity1

Post-translational modificationi

Acetylated once deposited into chromatin.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiA1C5F1

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the vps72/swc2 subunit of the SWR1 chromatin remodeling complex. Interacts also with rbp1/DNA-directed RNA polymerase II largest subunit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00000308

Structurei

3D structure databases

ProteinModelPortaliA1C5F1
SMRiA1C5F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

HOGENOMiHOG000234652
KOiK11251
OMAiKQRTQHN
OrthoDBiEOG092C5QJX

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

A1C5F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGKGKSVG GKAGSKDAAG KTQKSHSAKA GLQFPCGRVK RFLKNNTQNK
60 70 80 90 100
MRVGAKAAVY VTAVLEYLTA EVLELAGNAA KDLKVKRITP RHLQLAIRGD
110 120 130
EELDTLIRAT IAFGGVLPRI NRALLLKVEQ KKKNKSEA
Length:138
Mass (Da):14,820
Last modified:January 23, 2007 - v1
Checksum:i9B192C6C43C211E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027004 Genomic DNA Translation: EAW14919.1
RefSeqiXP_001276345.1, XM_001276344.1

Genome annotation databases

EnsemblFungiiCADACLAT00000312; CADACLAP00000308; CADACLAG00000312
GeneIDi4708462
KEGGiact:ACLA_003310

Entry informationi

Entry nameiH2AZ_ASPCL
AccessioniPrimary (citable) accession number: A1C5F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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