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A1C5F1 (H2AZ_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone H2A.Z
Gene names
Name:HTZ1
ORF Names:ACLA_003310
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and spt15/TBP recruitment to the target genes. Involved in chromosome stability By similarity.

Subunit structure

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the vps72/swc2 subunit of the SWR1 chromatin remodeling complex. Interacts also with rbp1/DNA-directed RNA polymerase II largest subunit By similarity.

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Post-translational modification

Acetylated once deposited into chromatin By similarity.

Sequence similarities

Belongs to the histone H2A family.

Ontologies

Keywords
   Cellular componentChromosome
Nucleosome core
Nucleus
   LigandDNA-binding
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processnucleosome assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleosome

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Histone H2A.Z
PRO_0000297717

Amino acid modifications

Modified residue51N6-acetyllysine By similarity
Modified residue121N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1C5F1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 9B192C6C43C211E2

FASTA13814,820
        10         20         30         40         50         60 
MPGGKGKSVG GKAGSKDAAG KTQKSHSAKA GLQFPCGRVK RFLKNNTQNK MRVGAKAAVY 

        70         80         90        100        110        120 
VTAVLEYLTA EVLELAGNAA KDLKVKRITP RHLQLAIRGD EELDTLIRAT IAFGGVLPRI 

       130 
NRALLLKVEQ KKKNKSEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027004 Genomic DNA. Translation: EAW14919.1.
RefSeqXP_001276345.1. XM_001276344.1.

3D structure databases

ProteinModelPortalA1C5F1.
SMRA1C5F1. Positions 1-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00000308.

Proteomic databases

PRIDEA1C5F1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00000312; CADACLAP00000308; CADACLAG00000312.
GeneID4708462.
KEGGact:ACLA_003310.

Phylogenomic databases

eggNOGCOG5262.
HOGENOMHOG000234652.
KOK11251.
OMAIHRYLMN.
OrthoDBEOG7GN30N.

Family and domain databases

Gene3D1.10.20.10. 1 hit.
InterProIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
[Graphical view]
PfamPF00125. Histone. 1 hit.
[Graphical view]
PRINTSPR00620. HISTONEH2A.
SMARTSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 1 hit.
ProtoNetSearch...

Entry information

Entry nameH2AZ_ASPCL
AccessionPrimary (citable) accession number: A1C5F1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families