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A1C4A5

- MYO1_ASPCL

UniProt

A1C4A5 - MYO1_ASPCL

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Protein

Myosin-1

Gene

myoA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1508ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Class I unconventional myosin
Type I myosin
Gene namesi
Name:myoA
ORF Names:ACLA_059080
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cytoplasmcytoskeletonactin patch By similarity
Note: Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12531253Myosin-1PRO_0000338536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei371 – 3711PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation of the TEDS site (Ser-371) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005561.

Structurei

3D structure databases

ProteinModelPortaliA1C4A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 729680Myosin motorAdd
BLAST
Domaini733 – 75321IQ 1Add
BLAST
Domaini754 – 77926IQ 2Add
BLAST
Domaini773 – 975203Myosin tailSequence AnalysisAdd
BLAST
Domaini1080 – 114162SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni418 – 50083Actin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi983 – 1199217Pro-richAdd
BLAST
Compositional biasi1020 – 108768Ala-richAdd
BLAST
Compositional biasi1248 – 12525Poly-Asp

Domaini

The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.By similarity
The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).By similarity

Sequence similaritiesi

Contains 2 IQ domains.Curated
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000260265.
KOiK10356.
OrthoDBiEOG7VDXXK.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C4A5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGHSRRPVGG EKKSRGFGRS KAAADVGDGR QAGKPQVKKA VFESTKKKEI
60 70 80 90 100
GVSDLTLLSK ISNEAINDNL KLRFEHDEIY TYIGHVLVSV NPFRDLGIYT
110 120 130 140 150
DNVLESYRGK NRLEVPPHVF AVAESAYYNM KSYKDNQCVI ISGESGAGKT
160 170 180 190 200
EAAKRIMQYI ASVSGGTDSS IQQIKEMVLA TNPLLESFGN AKTLRNNNSS
210 220 230 240 250
RFGKYLELEF NTNGEPVGAN ITNYLLEKSR VVGQITNERN FHIFYQFTKA
260 270 280 290 300
APQKYRDMFG IQQPQSYLYT SRSKCYDVPG IDDSAEFRDT VNAMNVIGMT
310 320 330 340 350
ESEQDNVFRM LAAILWIGNV QFAEDDSGNA AITDQSVVDF IAYLLEVDAA
360 370 380 390 400
QVNKAFTIRV METARGGRRG SIYEVPLNTV QALAVRDALA KAIYFNLFDW
410 420 430 440 450
IVQRVNSSLA ARGEIANSIG ILDIYGFEIF EKNSFEQLCI NYVNEKLQQI
460 470 480 490 500
FIQLTLKAEQ DEYAREQIQW TPIKYFDNKV VCSLIEDKRP PGVFAALNDA
510 520 530 540 550
CATAHADSGA ADNTFVGRLN FLSQNPNFEN RQGQFIVKHY AGDVSYAVTG
560 570 580 590 600
MTDKNKDQLL KDLLNLVGSS GNQFVHTLFP EQVNQDDKRR PPTASDKIKA
610 620 630 640 650
SANDLVATLM KAQPSYIRTI KPNDNKAPRE YNVGNVLHQI KYLGLQENVR
660 670 680 690 700
IRRAGFAYRQ TFDKFVERFY LLSPKTSYAG DYTWTGSAES GARQILKDTS
710 720 730 740 750
IPAEEYQMGI TKVFVKTPET LFALEAMRDR YWHNMAIRIQ RAWRNYLRYR
760 770 780 790 800
IECATRIQRF WRRTTGGLEF IKLRDQGHQL LNGRKERRRM SLLGSRRFLG
810 820 830 840 850
DYIGVGNKGG PGEMVRNGAG ISGSEDILFS CRGEVLVSKF GRSSKPAPRI
860 870 880 890 900
LVLTNRHIYI IAQNILNNQL VISSERTIPI GAIKAISASN LKDDWFSIVV
910 920 930 940 950
GSAQEPDPLL SCVFKTELFT HLNNALRGQL NLKIADHIEY SKKPGKMATV
960 970 980 990 1000
KVVKDPAVTG DDTYKSSTIH TGAGEPASSV SKPTPRPKPV SARPVTKGKL
1010 1020 1030 1040 1050
LRPGGPGGGP SKLASRPTPA AQPLPRATPQ PAAAQPAAPQ PAARVVPQPV
1060 1070 1080 1090 1100
AAVAASHART GSTASVRAPP PPPPAAAPAP KKPTAKALYD FNSQQPNELS
1110 1120 1130 1140 1150
IKAGEIVQIV SKEGNGWWLC MNMATSSQGW TPEAYLEEQV APAPKPTPPP
1160 1170 1180 1190 1200
PPPAAPRSTP TPVNGAAAAA KAKPAPPAPP AKRPNMAGRK AVPAPPPAPR
1210 1220 1230 1240 1250
DSAVSMNSHD SSGGSGRGTP NSASNASLAG GLAEALRARQ HAMQGKNDDD

DDW
Length:1,253
Mass (Da):137,388
Last modified:June 10, 2008 - v2
Checksum:i2B9EE08E2BE77772
GO

Sequence cautioni

The sequence EAW15245.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS026990 Genomic DNA. Translation: EAW15245.1. Different initiation.
RefSeqiXP_001276671.1. XM_001276670.1.

Genome annotation databases

GeneIDi4708852.
KEGGiact:ACLA_059080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS026990 Genomic DNA. Translation: EAW15245.1 . Different initiation.
RefSeqi XP_001276671.1. XM_001276670.1.

3D structure databases

ProteinModelPortali A1C4A5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4708852.
KEGGi act:ACLA_059080.

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000260265.
KOi K10356.
OrthoDBi EOG7VDXXK.

Family and domain databases

InterProi IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiMYO1_ASPCL
AccessioniPrimary (citable) accession number: A1C4A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3