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A1C4A5

- MYO1_ASPCL

UniProt

A1C4A5 - MYO1_ASPCL

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Protein
Myosin-1
Gene
myoA, ACLA_059080
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1508ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Class I unconventional myosin
Type I myosin
Gene namesi
Name:myoA
ORF Names:ACLA_059080
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cytoplasmcytoskeletonactin patch By similarity
Note: Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation By similarity.

GO - Cellular componenti

  1. actin cortical patch Source: UniProtKB-SubCell
  2. myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12531253Myosin-1
PRO_0000338536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei371 – 3711Phosphoserine By similarity

Post-translational modificationi

Phosphorylation of the TEDS site (Ser-371) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005561.

Structurei

3D structure databases

ProteinModelPortaliA1C4A5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 729680Myosin motor
Add
BLAST
Domaini733 – 75321IQ 1
Add
BLAST
Domaini754 – 77926IQ 2
Add
BLAST
Domaini1080 – 114162SH3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni418 – 50083Actin-binding By similarity
Add
BLAST
Regioni780 – 977198Basic, putative membrane-binding region By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi983 – 1199217Pro-rich
Add
BLAST
Compositional biasi1020 – 108768Ala-rich
Add
BLAST
Compositional biasi1248 – 12525Poly-Asp

Domaini

The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force By similarity.
The tail domain participates in molecular interactions that specify the role of the motor domain By similarity. It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding domain (TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).

Sequence similaritiesi

Contains 2 IQ domains.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000260265.
KOiK10356.
OrthoDBiEOG7VDXXK.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1C4A5-1 [UniParc]FASTAAdd to Basket

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MGHSRRPVGG EKKSRGFGRS KAAADVGDGR QAGKPQVKKA VFESTKKKEI     50
GVSDLTLLSK ISNEAINDNL KLRFEHDEIY TYIGHVLVSV NPFRDLGIYT 100
DNVLESYRGK NRLEVPPHVF AVAESAYYNM KSYKDNQCVI ISGESGAGKT 150
EAAKRIMQYI ASVSGGTDSS IQQIKEMVLA TNPLLESFGN AKTLRNNNSS 200
RFGKYLELEF NTNGEPVGAN ITNYLLEKSR VVGQITNERN FHIFYQFTKA 250
APQKYRDMFG IQQPQSYLYT SRSKCYDVPG IDDSAEFRDT VNAMNVIGMT 300
ESEQDNVFRM LAAILWIGNV QFAEDDSGNA AITDQSVVDF IAYLLEVDAA 350
QVNKAFTIRV METARGGRRG SIYEVPLNTV QALAVRDALA KAIYFNLFDW 400
IVQRVNSSLA ARGEIANSIG ILDIYGFEIF EKNSFEQLCI NYVNEKLQQI 450
FIQLTLKAEQ DEYAREQIQW TPIKYFDNKV VCSLIEDKRP PGVFAALNDA 500
CATAHADSGA ADNTFVGRLN FLSQNPNFEN RQGQFIVKHY AGDVSYAVTG 550
MTDKNKDQLL KDLLNLVGSS GNQFVHTLFP EQVNQDDKRR PPTASDKIKA 600
SANDLVATLM KAQPSYIRTI KPNDNKAPRE YNVGNVLHQI KYLGLQENVR 650
IRRAGFAYRQ TFDKFVERFY LLSPKTSYAG DYTWTGSAES GARQILKDTS 700
IPAEEYQMGI TKVFVKTPET LFALEAMRDR YWHNMAIRIQ RAWRNYLRYR 750
IECATRIQRF WRRTTGGLEF IKLRDQGHQL LNGRKERRRM SLLGSRRFLG 800
DYIGVGNKGG PGEMVRNGAG ISGSEDILFS CRGEVLVSKF GRSSKPAPRI 850
LVLTNRHIYI IAQNILNNQL VISSERTIPI GAIKAISASN LKDDWFSIVV 900
GSAQEPDPLL SCVFKTELFT HLNNALRGQL NLKIADHIEY SKKPGKMATV 950
KVVKDPAVTG DDTYKSSTIH TGAGEPASSV SKPTPRPKPV SARPVTKGKL 1000
LRPGGPGGGP SKLASRPTPA AQPLPRATPQ PAAAQPAAPQ PAARVVPQPV 1050
AAVAASHART GSTASVRAPP PPPPAAAPAP KKPTAKALYD FNSQQPNELS 1100
IKAGEIVQIV SKEGNGWWLC MNMATSSQGW TPEAYLEEQV APAPKPTPPP 1150
PPPAAPRSTP TPVNGAAAAA KAKPAPPAPP AKRPNMAGRK AVPAPPPAPR 1200
DSAVSMNSHD SSGGSGRGTP NSASNASLAG GLAEALRARQ HAMQGKNDDD 1250
DDW 1253
Length:1,253
Mass (Da):137,388
Last modified:June 10, 2008 - v2
Checksum:i2B9EE08E2BE77772
GO

Sequence cautioni

The sequence EAW15245.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS026990 Genomic DNA. Translation: EAW15245.1. Different initiation.
RefSeqiXP_001276671.1. XM_001276670.1.

Genome annotation databases

GeneIDi4708852.
KEGGiact:ACLA_059080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS026990 Genomic DNA. Translation: EAW15245.1 . Different initiation.
RefSeqi XP_001276671.1. XM_001276670.1.

3D structure databases

ProteinModelPortali A1C4A5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4708852.
KEGGi act:ACLA_059080.

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000260265.
KOi K10356.
OrthoDBi EOG7VDXXK.

Family and domain databases

InterProi IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiMYO1_ASPCL
AccessioniPrimary (citable) accession number: A1C4A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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