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Protein

Probable beta-glucosidase btgE

Gene

btgE

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei501 – 5011NucleophileBy similarity
Active sitei555 – 5551Proton donorBy similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase btgE (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase btgE
Cellobiase btgE
Gentiobiase btgE
Gene namesi
Name:btgE
ORF Names:ACLA_059020
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secretedcell wall By similarity
Note: Covalently-linked to the cell wall.By similarity

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 564546Probable beta-glucosidase btgEPRO_0000395130Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005509.

Structurei

3D structure databases

ProteinModelPortaliA1C499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000158427.
OMAiYSTDCDT.
OrthoDBiEOG73FQWG.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1C499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAFLATAA AIAGTAMADI AHMRRHGHDS FHQRRAVEQP APEADATCGC
60 70 80 90 100
TTEVVTSWGP PTLIPIATSS PSSTVTSEVV TTLHSTSYST VTLVVTPSGA
110 120 130 140 150
SPNRESAPAT PAVTLPTPGV TSFSTTGTYT IPATTLTVTH STTVCGATTT
160 170 180 190 200
ELPSGTHTYG GVTTVVDRHT TVVCPYATVE PSGSTVTSVI RTTTYVCPSA
210 220 230 240 250
GTYTIAPTTT YVPTSTVIVY PTPATITPGT YTQPAQTITV TRDNYIYVCP
260 270 280 290 300
FTGQQLPTTA PVAPATTAVP ATTTAVPATT TAVPATSSVA PSSSPSKPAA
310 320 330 340 350
PSGAVSGQMG MTYSPYTNEG GCKDKASIIS EVALLKSKGF THVRVYSTDC
360 370 380 390 400
GSLEFIGEAA RTSGLRMIIG VFIKQSGVAG AQDQVTAISK WAQWDLVSLI
410 420 430 440 450
VVGNESIQNH FCDASTLAGF IVSAKQSFKA AGYSGQVTTT EPINVWQANG
460 470 480 490 500
DALCGAVDII GANIHPFFNA DVSAAEAGKF VAQEFKTLKG ICPGKDVINL
510 520 530 540 550
ETGWPHSGEA NGKAIPSREE QAIAIKAIAD EVGSMSVFFS YFDDLWKQPG
560
AFGVERYWGC IENF
Length:564
Mass (Da):58,575
Last modified:January 23, 2007 - v1
Checksum:iB95D30B0D0B75AF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS026990 Genomic DNA. Translation: EAW15239.1.
RefSeqiXP_001276665.1. XM_001276664.1.

Genome annotation databases

EnsemblFungiiCADACLAT00005634; CADACLAP00005509; CADACLAG00005634.
GeneIDi4708849.
KEGGiact:ACLA_059020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS026990 Genomic DNA. Translation: EAW15239.1.
RefSeqiXP_001276665.1. XM_001276664.1.

3D structure databases

ProteinModelPortaliA1C499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00005509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00005634; CADACLAP00005509; CADACLAG00005634.
GeneIDi4708849.
KEGGiact:ACLA_059020.

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000158427.
OMAiYSTDCDT.
OrthoDBiEOG73FQWG.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBTGE_ASPCL
AccessioniPrimary (citable) accession number: A1C499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.