SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1C408

- 3HAO1_ASPCL

UniProt

A1C408 - 3HAO1_ASPCL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
3-hydroxyanthranilate 3,4-dioxygenase 1
Gene
bna1-1, ACLA_058050
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Dioxygen By similarity
Metal bindingi54 – 541Iron; catalytic By similarity
Metal bindingi60 – 601Iron; catalytic By similarity
Binding sitei60 – 601Substrate By similarity
Metal bindingi102 – 1021Iron; catalytic By similarity
Binding sitei106 – 1061Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Metal bindingi131 – 1311Divalent metal cation By similarity
Metal bindingi134 – 1341Divalent metal cation By similarity
Metal bindingi168 – 1681Divalent metal cation By similarity
Metal bindingi171 – 1711Divalent metal cation By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase 1 (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase 1
Short name:
3-HAO-1
3-hydroxyanthranilic acid dioxygenase 1
Short name:
HAD-1
Biosynthesis of nicotinic acid protein 1-1
Gene namesi
Name:bna1-1
ORF Names:ACLA_058050
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1921923-hydroxyanthranilate 3,4-dioxygenase 1UniRule annotation
PRO_0000361974Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00005585.

Structurei

3D structure databases

ProteinModelPortaliA1C408.
SMRiA1C408. Positions 5-179.

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG7QK0Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1C408-1 [UniParc]FASTAAdd to Basket

« Hide

MLPPALNIPK WLEANSHLLQ PPVNNYCVYH PSSPATAGYT VMIVGGPNAR    50
TDYHINTTPE FFYQYRGSML LKTVDTSVSP PVFQDIPIHE GSIFLLPANT 100
PHCPVRFKDT VGVVMEQPRA EGAVDQMRWY CRGCGEIVWE KQFVCTDLGT 150
QVKEVVEEFG ADQEKRTCKA CGTIAETRFK EGEIVQPPRF VE 192
Length:192
Mass (Da):21,563
Last modified:January 23, 2007 - v1
Checksum:i3361901AC98CDBF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS026990 Genomic DNA. Translation: EAW15148.1.
RefSeqiXP_001276574.1. XM_001276573.1.

Genome annotation databases

EnsemblFungiiCADACLAT00005710; CADACLAP00005585; CADACLAG00005710.
GeneIDi4708890.
KEGGiact:ACLA_058050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS026990 Genomic DNA. Translation: EAW15148.1 .
RefSeqi XP_001276574.1. XM_001276573.1.

3D structure databases

ProteinModelPortali A1C408.
SMRi A1C408. Positions 5-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00005585.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00005710 ; CADACLAP00005585 ; CADACLAG00005710 .
GeneIDi 4708890.
KEGGi act:ACLA_058050.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG7QK0Q0.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry namei3HAO1_ASPCL
AccessioniPrimary (citable) accession number: A1C408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi