A1C2E7 (A1C2E7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Myostatin EMBL ABI48369.1

Gene names

Name:

GDF8 EMBL ABI48369.1

Organism

Homo sapiens (Human) EMBL ABI48369.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS001111
Molecular function	Growth factor RuleBase RU000354 SAAS SAAS001111
PTM	Disulfide bond SAAS SAAS001111
Gene Ontology (GO)
Biological_process	growth Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1C2E7 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 6E81CC3EC10F07C3	FASTA	375	42,754
	10 20 30 40 50 60 MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEXIKIQI 70 80 90 100 110 120 LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT 130 140 150 160 170 180 MPTESDFLXQ VDGKPKCCFF KFSSKIQYNK VVXAQLWIYL RPVETPTTVF VQILRLIKPM 190 200 210 220 230 240 KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT 250 260 270 280 290 300 FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA 310 320 330 340 350 360 PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII 370 YGKIPAMVVD RCGCS

References

[1]	"Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth." Saunders M.A., Good J.M., Lawrence E.C., Ferrell R.E., Li W.H., Nachman M.W. Am. J. Hum. Genet. 79:1089-1097(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: AFRAM_A01 EMBL ABI48369.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ927046 Genomic DNA. Translation: ABI48369.1.
IPI	IPI00023751.
3D structure databases
ProteinModelPortal	A1C2E7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000217.
Family and domain databases
InterPro	IPR015616. GDF_8. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit. PTHR11848:SF13. PTHR11848:SF13. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35460351.

Entry information

Entry name

A1C2E7_HUMAN

Accession

Primary (citable) accession number: A1C2E7

Entry history

Integrated into UniProtKB/TrEMBL:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.