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Protein
Submitted name:

Alpha actinin 1a

Gene

Actn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha actinin 1aImported
Submitted name:
Alpha-actinin-1Imported
Gene namesi
Name:Actn1Imported
Synonyms:Actn1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2137706. Actn1.

PTM / Processingi

Proteomic databases

MaxQBiA1BN54.

PTM databases

iPTMnetiA1BN54.
SwissPalmiA1BN54.

Expressioni

Gene expression databases

ExpressionAtlasiA1BN54. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiA1BN54. 3 interactions.
STRINGi10090.ENSMUSP00000021554.

Structurei

3D structure databases

SMRiA1BN54. Positions 27-885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 135105Actin-bindingInterPro annotationAdd
BLAST
Domaini144 – 247104Actin-bindingInterPro annotationAdd
BLAST
Domaini746 – 78136EF-handInterPro annotationAdd
BLAST
Domaini782 – 81736EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili265 – 29228Sequence analysisAdd
BLAST
Coiled coili430 – 46435Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOVERGENiHBG050453.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR026921. Alpha-actinin_1.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR014837. EF-hand_Ca_insen.
IPR002048. EF_hand_dom.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR11915:SF241. PTHR11915:SF241. 1 hit.
PfamiPF00307. CH. 2 hits.
PF08726. EFhand_Ca_insen. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00054. EFh. 2 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1BN54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHYDSQQTN DYMQPEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT
60 70 80 90 100
QIENIEEDFR DGLKLMLLLE VISGERLAKP ERGKMRVHKI SNVNKALDFI
110 120 130 140 150
ASKGVKLVSI GAEEIVDGNV KMTLGMIWTI ILRFAIQDIS VEETSAKEGL
160 170 180 190 200
LLWCQRKTAP YKNVNIQNFH ISWKDGLGFC ALIHRHRPEL IDYGKLRKDD
210 220 230 240 250
PLTNLNTAFD VAERFLDIPK MLDAEDIVGT ARPDEKAIMT YVSSFYHAFS
260 270 280 290 300
GAQKAETAAN RICKVLAVNQ ENEQLMEDYE KLASDLLEWI RRTIPWLENR
310 320 330 340 350
VPENTMHAMQ QKLEDFRDYR RLHKPPKVQE KCQLEINFNT LQTKLRLSNR
360 370 380 390 400
PAFMPSEGRM VSDINNAWGC LEQAEKGYEE WLLNEIRRLE RLDHLAEKFR
410 420 430 440 450
QKASIHEAWT DGKEAMLRQK DYETATLSEI KALLKKHEAF ESDLAAHQDR
460 470 480 490 500
VEQIAAIAQE LNELDYYDSP SVNARCQKIC DQWDNLGALT QKRREALERT
510 520 530 540 550
EKLLETIDQL YLEYAKRAAP FNNWMEGAME DLQDTFIVHT IEEIQGLTTA
560 570 580 590 600
HEQFKATLPD ADKERLAILG IHNEVSKIVQ TYHVNMAGTN PYTTITPQEI
610 620 630 640 650
NGKWDHVRQL VPRRDQALTE EHARQQHNER LRKQFGAQAN VIGPWIQTKM
660 670 680 690 700
EEIGRISIEM HGTLEDQLSH LRQYEKSIVN YKPKIDQLEC DHQLIQEALI
710 720 730 740 750
FDNKHTNYNM EHIRVGWEQL LTTIARTINE VENQILTRDA KGISQEQMNE
760 770 780 790 800
FRASFNHFDR KKTGMMDTDD FRACLISMGY NMGEAEFARI MSIVDPNRLG
810 820 830 840 850
VVTFQAFIDF MSRETADTDT ADQVMASFKI LAGDKNYITE DELRRELPPD
860 870 880
QAEYCIARMA PYAGPDSVPG ALDYMSFSTA LYGESDL
Length:887
Mass (Da):102,720
Last modified:January 23, 2007 - v1
Checksum:i3DE9A4FB303F7F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108401 Genomic DNA. No translation available.
CT030161 Genomic DNA. No translation available.
DQ288940 mRNA. Translation: ABB88726.1.
RefSeqiXP_006515451.1. XM_006515388.2.
UniGeneiMm.253564.
Mm.403477.

Genome annotation databases

EnsembliENSMUST00000167327; ENSMUSP00000127176; ENSMUSG00000015143.
GeneIDi109711.
UCSCiuc007oaq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108401 Genomic DNA. No translation available.
CT030161 Genomic DNA. No translation available.
DQ288940 mRNA. Translation: ABB88726.1.
RefSeqiXP_006515451.1. XM_006515388.2.
UniGeneiMm.253564.
Mm.403477.

3D structure databases

SMRiA1BN54. Positions 27-885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA1BN54. 3 interactions.
STRINGi10090.ENSMUSP00000021554.

PTM databases

iPTMnetiA1BN54.
SwissPalmiA1BN54.

Proteomic databases

MaxQBiA1BN54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167327; ENSMUSP00000127176; ENSMUSG00000015143.
GeneIDi109711.
UCSCiuc007oaq.2. mouse.

Organism-specific databases

CTDi87.
MGIiMGI:2137706. Actn1.

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOVERGENiHBG050453.

Miscellaneous databases

ChiTaRSiActn1. mouse.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiA1BN54. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR026921. Alpha-actinin_1.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR014837. EF-hand_Ca_insen.
IPR002048. EF_hand_dom.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR11915:SF241. PTHR11915:SF241. 1 hit.
PfamiPF00307. CH. 2 hits.
PF08726. EFhand_Ca_insen. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00054. EFh. 2 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin."
    Zhao Z., Deocharan B., Scherer P.E., Ozelius L.J., Putterman C.
    J. Immunol. 176:7704-7714(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA1BN54_MOUSE
AccessioniPrimary (citable) accession number: A1BN54
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.