Reviewed, UniProtKB/Swiss-Prot A1BJI2 (PYRE_CHLPD)

Names and origin

Protein names

Recommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10

Gene names

Name:	pyrE
Ordered Locus Names:	Cpha266_2571

Organism

Chlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP]

Taxonomic identifier

290317 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity.
Catalytic activity	Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Orotate phosphoribosyltransferase HAMAP MF_01208		PRO_1000138773
Regions
	Region	114 – 122	9	5-phosphoribose 1-diphosphate binding By similarity
Sites
	Binding site	118	1	Orotate By similarity
	Binding site	146	1	Orotate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1BJI2-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: D67C459E6812440F	FASTA	193	20,697
	10 20 30 40 50 60 MNQPPMLDIF RSTGALLEGH FKLTSGRHSN TYFQCAKVLQ HPEHLSAVCH KIAAHFSQKG 70 80 90 100 110 120 VDTVISPAIG GIVAGTETGR QLGVKTIFAE RKDGRMTIRR GFSVAPGEKV LVIEDVITTG 130 140 150 160 170 180 GSVQEVIELL KNAGALIIGV GCVVDRSNGK VRLTDDQYAV LSMEVVSYAP EECPLCKEGM 190 PIDAPGSRAN QQP

References

[1]

"Complete sequence of Chlorobium phaeobacteroides DSM 266." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000492 Genomic DNA. Translation: ABL66559.1.
RefSeq	YP_912983.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1BJI2.
Genome annotation databases
GeneID	4569086.
GenomeReviews	Gene locus Cpha266_2571 in contig CP000492_GR.
KEGG	cph:Cpha266_2571.
NMPDR	fig|290317.7.peg.2690.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YLQSAKV.
Family and domain databases
HAMAP	MF_01208. [Tree]
InterPro	IPR006273. Orotate_PRibTrfase_thermus-typ. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01367. pyrE_Therm. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRE_CHLPD

Accession

Primary (citable) accession number: A1BJI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)