Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homoserine kinase

Gene

thrB

Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Cpha266_2583)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. no protein annotated in this organism
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 110ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA290317:G1G7N-2698-MONOMER
UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Cpha266_2545
OrganismiChlorobium phaeobacteroides (strain DSM 266)
Taxonomic identifieri290317 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008701 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000491201 – 320Homoserine kinaseAdd BLAST320

Proteomic databases

PRIDEiA1BJF6

Interactioni

Protein-protein interaction databases

STRINGi290317.Cpha266_2545

Structurei

3D structure databases

ProteinModelPortaliA1BJF6
SMRiA1BJF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RDY Bacteria
COG0083 LUCA
HOGENOMiHOG000247197
KOiK00872
OMAiPDNVAPC
OrthoDBiPOG091H020X

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00384 Homoser_kinase, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR000870 Homoserine_kinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR20861:SF1 PTHR20861:SF1, 1 hit
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000676 Homoser_kin, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00191 thrB, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

A1BJF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVRGFASA TVGNVACGFD VLGFAITEPG DEVILTLHEE RKSECPVSIT
60 70 80 90 100
AISGDGGALP LDPKKNTSSF VVLKFLEYIR TSKGIDFKGH IDLELKKNLP
110 120 130 140 150
LSSGMGSSAA SAAAALAAAN ELLGQPCSKM ELVHFAVEGE RVACGSAHAD
160 170 180 190 200
NAAPAILGNF VLIRSYAPLD LITIPSPEHL FCTLVHPHTE LKTSFARSVL
210 220 230 240 250
PRSIPLKTAT QQWGNVGALI AGLLKSDYDL IGRALVDVVA EPKRAPLIPG
260 270 280 290 300
FLDVKHAAID CGALGCSIAG SGPSVFAFSS SKETAERVGQ AMREAFLLPE
310 320
TNLKSDMWVS PICKEGAKVL
Length:320
Mass (Da):33,665
Last modified:January 23, 2007 - v1
Checksum:iC08D7ED0780598A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000492 Genomic DNA Translation: ABL66533.1
RefSeqiWP_011746310.1, NC_008639.1

Genome annotation databases

EnsemblBacteriaiABL66533; ABL66533; Cpha266_2545
KEGGicph:Cpha266_2545

Similar proteinsi

Entry informationi

Entry nameiKHSE_CHLPD
AccessioniPrimary (citable) accession number: A1BJF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health