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A1BJA7

- GCSPB_CHLPD

UniProt

A1BJA7 - GCSPB_CHLPD

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Cpha266_2496
Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCPHA290317:GHX4-2539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Cpha266_2496
OrganismiChlorobium phaeobacteroides (strain DSM 266)
Taxonomic identifieri290317 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
ProteomesiUP000008701: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000045690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei269 – 2691N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi290317.Cpha266_2496.

Structurei

3D structure databases

ProteinModelPortaliA1BJA7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiKPVMHEF.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A1BJA7-1 [UniParc]FASTAAdd to Basket

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MREKLIFDLS RNGRKGYSLS KNDLPETSVA AVIPSKFLRT TPAELPEVPE    50
SEVVRHFIRL SNLNYHVDKN MYPLGSCTMK YNPKVNDYTC DLPGFSTLHP 100
LQPSETTQGA LRLMYELSSM LSEIAGMAAV SLQPAAGAHG ELTGILLIKK 150
YHEAQGKMRN KLLVVDSAHG TNPASAAIAG YEIISVRSNA DGRTDLEDLK 200
ARLQSDVAAL MLTNPNTIGL FEKDILAIER MVHENGSLLY MDGANMNALL 250
GITRPGDMGF DVVHYNLHKT FSAPHGGGGP GSGPIGVSAR LAGYLPVPVI 300
EKEESATGTS YRLNYDRPES IGRMISFYGN FSVLVRAYTY IRMLGPEGLR 350
RVSENAIINA NYLLSLLLER YDLPYPKSVM HEFCLSGDRQ KKANGVKTLD 400
MAKRLLDYGF HAPTIYFPLI VSEALMIEPT ETETKETLER FAEAMIAIAD 450
EAENNPALVK SAPETTPVKR LDEAQASRQL NICCSL 486
Length:486
Mass (Da):53,462
Last modified:January 23, 2007 - v1
Checksum:i13468D674BAA4E87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000492 Genomic DNA. Translation: ABL66484.1.
RefSeqiWP_011746261.1. NC_008639.1.
YP_912908.1. NC_008639.1.

Genome annotation databases

EnsemblBacteriaiABL66484; ABL66484; Cpha266_2496.
GeneIDi4568549.
KEGGicph:Cpha266_2496.
PATRICi21393649. VBIChlPha122104_2982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000492 Genomic DNA. Translation: ABL66484.1 .
RefSeqi WP_011746261.1. NC_008639.1.
YP_912908.1. NC_008639.1.

3D structure databases

ProteinModelPortali A1BJA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290317.Cpha266_2496.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL66484 ; ABL66484 ; Cpha266_2496 .
GeneIDi 4568549.
KEGGi cph:Cpha266_2496.
PATRICi 21393649. VBIChlPha122104_2982.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi KPVMHEF.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CPHA290317:GHX4-2539-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chlorobium phaeobacteroides DSM 266."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 266.

Entry informationi

Entry nameiGCSPB_CHLPD
AccessioniPrimary (citable) accession number: A1BJA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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