A1BI02 (GCST_CHLPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Cpha266_2017

Organism

Chlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP]

Taxonomic identifier

290317 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_1000047655

Sequences

	Sequence		Length	Mass (Da)
	A1BI02 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 510331E5B8A9AE4A	FASTA	365	40,686
	10 20 30 40 50 60 MKKTALYHWH EQAGARIIDF GGYLMPVQYS GIIAEHRAVR SAAGLFDVSH MGNFYVTGER 70 80 90 100 110 120 SEAFLQYMVT NDLSKVRDGE AQYNLMLYPN GGVVDDLIIY RLDSKTFFLI VNASNTEKDY 130 140 150 160 170 180 AWLQQHIGAF DGVCLEDHTD RLSLIALQGP VAIDIVKTVF PSVDFDALLQ FQFCRTLYGD 190 200 210 220 230 240 APVMIARTGY TGEKGVEICL PNEAALPLWE ALYDAGRACG ISPVGLGARD TLRLEMGYSL 250 260 270 280 290 300 YGHEIDQDIN PLEARLKWAV KMDKGSFIGR EACQQVELHL TRGVAGFSIE SRVLPRQHCK 310 320 330 340 350 360 VYNTDRQEIG WVCSGTLSPT LQEPIGTCNI VRKYITSGDS VFVDVRGTLH KGEIRRLPFV KTSLG

References

[1]

"Complete sequence of Chlorobium phaeobacteroides DSM 266." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 266.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000492 Genomic DNA. Translation: ABL66029.1.
RefSeq	YP_912453.1. NC_008639.1.
3D structure databases
ProteinModelPortal	A1BI02.
ModBase	Search...
Protein-protein interaction databases
STRING	A1BI02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4569544.
GenomeReviews	Gene locus Cpha266_2017 in contig CP000492_GR.
KEGG	cph:Cpha266_2017.
NMPDR	fig|290317.7.peg.2129.
PATRIC	21392488. VBIChlPha122104_2404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	A1BI02.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CHLPD

Accession

Primary (citable) accession number: A1BI02

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program