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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADUniRule annotation1
Binding sitei81SubstrateUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei94NADUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NADUniRule annotation6
Nucleotide bindingi117 – 119NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Cpha266_1900
OrganismiChlorobium phaeobacteroides (strain DSM 266)
Taxonomic identifieri290317 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008701 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000264691 – 310Malate dehydrogenaseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi290317.Cpha266_1900.

Structurei

3D structure databases

ProteinModelPortaliA1BHN9.
SMRiA1BHN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A1BHN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISVIGAGN VGATAAHRLA EKQLAHEVVL IDIVEGIPQG KALDMYESGP
60 70 80 90 100
VGLFDTAIHG SNDYMASADS DIVLITAGLA RKPGMTREDL LMKNAGIVKE
110 120 130 140 150
VTDQVMKHSS NPILVMVSNP LDVMTFVAHA SSGLGKERVI GMAGVLDAAR
160 170 180 190 200
FRSFIAEELN VSMQDVNAFV LGGHGDSMVP VVKYTSVAGI PITELLSQEK
210 220 230 240 250
IDALVERTRN GGVEIVNYLK NGSAFYAPAA SAVEMIEAIV KDRKRILACT
260 270 280 290 300
TLLEGEYGIN NVFCGVPVKI GKNGVEEILE INLAPAELDA LKHSASLVQE
310
NCKSLEALLA
Length:310
Mass (Da):32,910
Last modified:January 23, 2007 - v1
Checksum:i9F1ADCDEB9474F6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000492 Genomic DNA. Translation: ABL65916.1.
RefSeqiWP_011745723.1. NC_008639.1.

Genome annotation databases

EnsemblBacteriaiABL65916; ABL65916; Cpha266_1900.
KEGGicph:Cpha266_1900.

Similar proteinsi

Entry informationi

Entry nameiMDH_CHLPD
AccessioniPrimary (citable) accession number: A1BHN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families