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Protein

Argininosuccinate synthase

Gene

argG

Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87CitrullineUniRule annotation1
Binding sitei117ATP; via amide nitrogenUniRule annotation1
Binding sitei119AspartateUniRule annotation1
Binding sitei123AspartateUniRule annotation1
Binding sitei123CitrullineUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei127CitrullineUniRule annotation1
Binding sitei176CitrullineUniRule annotation1
Binding sitei185CitrullineUniRule annotation1
Binding sitei261CitrullineUniRule annotation1
Binding sitei273CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 17ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHA290317:G1G7N-1390-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Cpha266_1325
OrganismiChlorobium phaeobacteroides (strain DSM 266)
Taxonomic identifieri290317 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008701 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000003911 – 400Argininosuccinate synthaseAdd BLAST400

Proteomic databases

PRIDEiA1BG29

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290317.Cpha266_1325

Structurei

3D structure databases

ProteinModelPortaliA1BG29
SMRiA1BG29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1BG29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEKIAIAY SGGLDTSIMI KWLKDKYDAE IVAVTGNLGQ QKEIENLESK
60 70 80 90 100
AIATGASAFQ FVDLRKEFVE EYIWKALKAG ALYEDVYPLA TALGRPLLAK
110 120 130 140 150
AIVDAALAEG CTMLAHGCTG KGNDQVRFEV TFASLAPHLK VLAPLREWEF
160 170 180 190 200
TSREAEIAYA LEHNIPVSAT KKSPYSIDEN IWGISIECGV LEDPMVAPPE
210 220 230 240 250
DAYQITTSPE NAPDRPTVVD IEFVQGVPVS LDGKTMSGLE LIMKLNETGA
260 270 280 290 300
ANGVGRLDMI ENRVVGIKSR EIYEAPAATI LHFAHRELER LTLEKTVFQY
310 320 330 340 350
KKNISQDYAN IIYNGLWFSP MRHALDAFIE ETQKPVTGLV RVKLYKGSLS
360 370 380 390 400
LLGRTSPNSL YNEELATYTE ADTFNHKAAA GFIHLYGLGL KTFSEVNPAR
Length:400
Mass (Da):44,154
Last modified:January 23, 2007 - v1
Checksum:iE69D65C15A5F0A00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000492 Genomic DNA Translation: ABL65356.1
RefSeqiWP_011745179.1, NC_008639.1

Genome annotation databases

EnsemblBacteriaiABL65356; ABL65356; Cpha266_1325
KEGGicph:Cpha266_1325

Similar proteinsi

Entry informationi

Entry nameiASSY_CHLPD
AccessioniPrimary (citable) accession number: A1BG29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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