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Protein

Catalase-peroxidase

Gene

katG

Organism
Chlorobium phaeobacteroides (strain DSM 266)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi261 – 2611Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCPHA290317:GHX4-767-MONOMER.

Protein family/group databases

PeroxiBasei2369. CphCP01_DSM266.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Cpha266_0755
OrganismiChlorobium phaeobacteroides (strain DSM 266)
Taxonomic identifieri290317 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupChlorobium
Proteomesi
  • UP000008701 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Catalase-peroxidasePRO_0000354760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246)UniRule annotation
Cross-linki220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1BEI1.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290317.Cpha266_0755.

Structurei

3D structure databases

ProteinModelPortaliA1BEI1.
SMRiA1BEI1. Positions 25-732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1BEI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQSKCPVT GRTAGNPVAG GSMLNRDWWP NQLHLDMLHQ HSSLVNPMGD
60 70 80 90 100
EFRYKEEFRK LDLGAVKKDL YALMTDSQEW WPADYGHYGG LFIRMAWHSA
110 120 130 140 150
GTYRTSDGRG GGGRGNQRFA PLNSWPDNAN LDKARRLLWP IKQKYGKMLS
160 170 180 190 200
WADLMILAGN CALESMGFKT FGFGGGRVDI WEPEEDIYWG KEVEWLGNNR
210 220 230 240 250
YSGERDLENP LAAVQMGLIY VNPEGPDGNP DPVAAGRDIR ETFARMAMND
260 270 280 290 300
EETVALVAGG HTFGKCHGVG DPNLIGPEPE AAGIEEQGLG WKSGYGSGKG
310 320 330 340 350
DETMTSGLEG AWTPDPIHWD MGYLGMLFKY EWELTKSPAG AWQWKPKDVA
360 370 380 390 400
EEDLAPAAHD PSKRVPTMMT TADLAMRMDP VYGPISRRYY EHPDQFADAF
410 420 430 440 450
ARAWFKLTHR DMGPKSRYLG AEVPAEDLIW QDPVPAVDHE LIGEGEIAEL
460 470 480 490 500
KKRLLASGLP IPELVSTTWA SASTFRGSDK RGGANGSRIR LAPQKDWEVN
510 520 530 540 550
QPEQLQRVLE KLEEIRHAFN GEQSGGKRVS LADLIVLGGC AAVEEAARRA
560 570 580 590 600
GNDVTIPFAP GRTDASQAET DVESFAVLEP LADGFRNYAR QKYSVTPEEM
610 620 630 640 650
LVDRSQLLTL TATEMTVLLG GLRVLGANFR QSPHGVFTKR HETLTNDFFV
660 670 680 690 700
NLLDMGTEWK PVSKEHDTFE GRDRKTGEPR WSATRVDLIF GSNARLRAIA
710 720 730
EVYGSDDAQE KFVQDFVAAW NKVMNLDRFE IS
Length:732
Mass (Da):81,551
Last modified:January 23, 2007 - v1
Checksum:iC5EF26974D8212EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000492 Genomic DNA. Translation: ABL64808.1.
RefSeqiWP_011744637.1. NC_008639.1.

Genome annotation databases

EnsemblBacteriaiABL64808; ABL64808; Cpha266_0755.
KEGGicph:Cpha266_0755.
PATRICi21389373. VBIChlPha122104_0871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000492 Genomic DNA. Translation: ABL64808.1.
RefSeqiWP_011744637.1. NC_008639.1.

3D structure databases

ProteinModelPortaliA1BEI1.
SMRiA1BEI1. Positions 25-732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290317.Cpha266_0755.

Protein family/group databases

PeroxiBasei2369. CphCP01_DSM266.

Proteomic databases

PRIDEiA1BEI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL64808; ABL64808; Cpha266_0755.
KEGGicph:Cpha266_0755.
PATRICi21389373. VBIChlPha122104_0871.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciCPHA290317:GHX4-767-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_CHLPD
AccessioniPrimary (citable) accession number: A1BEI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.