Reviewed, UniProtKB/Swiss-Prot A1BED6 (AROE_CHLPD)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Cpha266_0708

Organism

Chlorobium phaeobacteroides (strain DSM 266) [Complete proteome] [HAMAP]

Taxonomic identifier

290317 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobium/Pelodictyon group › Chlorobium

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021271
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A1BED6-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: C7F32C3251928A68	FASTA	295	31,608
	10 20 30 40 50 60 MMQPEKILGL IGRNIAYSRS PLIHNTACDL LALPYVYTIF NIASADLIEP AIAGARALGI 70 80 90 100 110 120 AGLNVTTPYK TTVVPFLDEL SPEAASIGAV NTIVNNNGHL AGYNTDIAGF AAPLRPYAQR 130 140 150 160 170 180 IKGNPVSVFG NGGAALAAIE AFRIFFHPCC VYLFVRDSAK ASAMLENYVH RDIVTLCLIE 190 200 210 220 230 240 ELFSGESGAI AKIQRSLVIV NATPIGTAGR QNETETSILP LDTELLHPDH IVYDMVYNPL 250 260 270 280 290 FTPLIKAAKA SGAATISGIE MLLGQAARSF ELWTGKEMPL EQVRAVLINN LLSSP

References

[1]

"Complete sequence of Chlorobium phaeobacteroides DSM 266." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J., Bryant D.A., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000492 Genomic DNA. Translation: ABL64763.1.
RefSeq	YP_911187.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1BED6.
Genome annotation databases
GeneID	4569882.
GenomeReviews	Gene locus Cpha266_0708 in contig CP000492_GR.
KEGG	cph:Cpha266_0708.
NMPDR	fig|290317.7.peg.743.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VYTIFNI.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CHLPD

Accession

Primary (citable) accession number: A1BED6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)